HOME >> MEDICINE >> NEWS
Johns Hopkins researchers discover key protein linked to transverse myelitis and multiple sclerosis

Hopkins researchers have discovered a single molecule that is a cause of an autoimmune disease in the central nervous system, called transverse myelitis (TM), that is related to multiple sclerosis.

In a study published in the October issue of The Journal of Clinical Investigation, psychiatrist Adam Kaplin, M.D., Ph.D., an assistant professor at The Johns Hopkins University School of Medicine, and neurologist Douglas Kerr, M.D., Ph.D., also an assistant professor at Hopkins, showed that the levels of the protein, IL-6, are dramatically elevated in the spinal fluid of transverse myelitis (TM) patients.

Although the majority of TM patients suffer a single attack, 15 percent to 30 percent of patients go on to develop full-blown MS. TM evolves rapidly and without warning and usually results in permanent impairment, including weakness of the legs and arms, bowel and bladder dysfunction, pain and paralysis.

IL-6 is a chemical messenger that cells of the immune system use to communicate with one another. One of the cell types injured by high levels of IL-6 includes oligodendrocytes, which help produce the protective myelin sheath coating around nerve cells. The findings offer one possible mechanism responsible for demyelinating disorders, such as TM and MS, and may aid in the development of effective therapies against these disorders, the researchers say.

"This is the first time a single culprit has been identified as causing a CNS autoimmune disease," said Kaplin.

The researchers began investigating the protein IL-6 when they became aware that TM patients suffered from memory impairment and depression. IL-6 has been implicated in mood and concentration disorders.

"This discovery is a success story that begins with listening carefully to what patients are telling us about their suffering and then collaborating across disciplines to open up new avenues of investigation," said Kaplin.

"TM is related to other autoimmune
'"/>

Contact: Eric Vohr
evohr1@jhmi.edu
410-955-8665
Johns Hopkins Medical Institutions
23-Sep-2005


Page: 1 2 3

Related medicine news :

1. Johns Hopkins begins aggressive screening for superbugs in children
2. Johns Hopkins develops pancreas cancer risk model
3. March of Dimes, Johnson & Johnson Pediatric Institute launch prematurity prevention partnership
4. Diagnosis and referrals for kidney disease fall well short of need, Johns Hopkins study shows
5. Johns Hopkins Childrens Center to lead largest-ever study on kidney disease in children
6. Johns Hopkins lab scientists tame overactive CF protein
7. Two tests better than one for diabetes control, Johns Hopkins expert tells doctors
8. Johns Hopkins scientists exploit novel route to reverse enlarged hearts in obese mice
9. Johns Hopkins scientists map brain area that may aid hunt for human brain stem cells
10. Johns Hopkins study suggests link between caffeine dependence and family history of alcoholism
11. Johns Hopkins flu expert calls for mandatory vaccination of health care workers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/17/2017)... ... ... Today, FloSports , a global leader in live digital sports and ... a long-term extension of their media partnership. The partnership, which began in 2013, will ... premier events exclusively on FloWrestling.com as well as usage of the FloArena meet management ...
(Date:1/16/2017)... Costa Mesa, California (PRWEB) , ... January 16, 2017 , ... ... Since 2014, Dr. Beazley has served on CalSouthern’s Board of Trustees and as a ... Sciences. In addition, he has been a professor of psychology at Pepperdine University, where ...
(Date:1/16/2017)... ... January 16, 2017 , ... Anybody who may be looking for a substance ... released by Serenity Recovery, a holistic treatment center for addiction located in Marne, MI. ... and testimonials from patients and staff that visited the 2016 Recovery Palooza support event ...
(Date:1/16/2017)... ... January 16, 2017 , ... Specialty Technical Publishers ... International Audit Protocol Consortium (IAPC) EHS audit protocol for Singapore . Leading ... of their EHS regulatory obligations and rapidly collect, share, archive, and export audit ...
(Date:1/16/2017)... CA (PRWEB) , ... January 16, 2017 , ... ... manuscript in the Aesthetic Surgery Journal , the official journal of The ... conducted on lower eyelid retraction surgery. The procedure is designed to correct drooping, ...
Breaking Medicine News(10 mins):
(Date:1/17/2017)... Jan. 17, 2017 Tempus, a technology ... and University Hospitals Seidman Cancer Center have joined ... genomic data, advanced molecular analysis and clinical decision ... and healthcare providers. As part ... and transcriptomic sequencing and analysis for ovarian and ...
(Date:1/17/2017)... Md. , Jan. 17, 2017  CSSi, the ... for the clinical research industry, will exhibit at the ... Operations Executives (SCOPE 2017), taking place from Tuesday, January ... Regency Miami in Miami, FL. ... newest proprietary technology platform, SmartStudy™ EMR, which provides a ...
(Date:1/17/2017)... , Jan. 17, 2017  Bayer today announced the ... its Pharmaceuticals business in the Americas, comprising the ... and Latin America . In this role, ... of the Board of Management of Bayer AG and President ... and highly respected leader in the pharmaceutical industry and I,m ...
Breaking Medicine Technology:
Cached News: