HOME >> MEDICINE >> NEWS
Johns Hopkins researchers discover key protein linked to transverse myelitis and multiple sclerosis

Hopkins researchers have discovered a single molecule that is a cause of an autoimmune disease in the central nervous system, called transverse myelitis (TM), that is related to multiple sclerosis.

In a study published in the October issue of The Journal of Clinical Investigation, psychiatrist Adam Kaplin, M.D., Ph.D., an assistant professor at The Johns Hopkins University School of Medicine, and neurologist Douglas Kerr, M.D., Ph.D., also an assistant professor at Hopkins, showed that the levels of the protein, IL-6, are dramatically elevated in the spinal fluid of transverse myelitis (TM) patients.

Although the majority of TM patients suffer a single attack, 15 percent to 30 percent of patients go on to develop full-blown MS. TM evolves rapidly and without warning and usually results in permanent impairment, including weakness of the legs and arms, bowel and bladder dysfunction, pain and paralysis.

IL-6 is a chemical messenger that cells of the immune system use to communicate with one another. One of the cell types injured by high levels of IL-6 includes oligodendrocytes, which help produce the protective myelin sheath coating around nerve cells. The findings offer one possible mechanism responsible for demyelinating disorders, such as TM and MS, and may aid in the development of effective therapies against these disorders, the researchers say.

"This is the first time a single culprit has been identified as causing a CNS autoimmune disease," said Kaplin.

The researchers began investigating the protein IL-6 when they became aware that TM patients suffered from memory impairment and depression. IL-6 has been implicated in mood and concentration disorders.

"This discovery is a success story that begins with listening carefully to what patients are telling us about their suffering and then collaborating across disciplines to open up new avenues of investigation," said Kaplin.

"TM is related to other autoimmune
'"/>

Contact: Eric Vohr
evohr1@jhmi.edu
410-955-8665
Johns Hopkins Medical Institutions
23-Sep-2005


Page: 1 2 3

Related medicine news :

1. Johns Hopkins begins aggressive screening for superbugs in children
2. Johns Hopkins develops pancreas cancer risk model
3. March of Dimes, Johnson & Johnson Pediatric Institute launch prematurity prevention partnership
4. Diagnosis and referrals for kidney disease fall well short of need, Johns Hopkins study shows
5. Johns Hopkins Childrens Center to lead largest-ever study on kidney disease in children
6. Johns Hopkins lab scientists tame overactive CF protein
7. Two tests better than one for diabetes control, Johns Hopkins expert tells doctors
8. Johns Hopkins scientists exploit novel route to reverse enlarged hearts in obese mice
9. Johns Hopkins scientists map brain area that may aid hunt for human brain stem cells
10. Johns Hopkins study suggests link between caffeine dependence and family history of alcoholism
11. Johns Hopkins flu expert calls for mandatory vaccination of health care workers

Post Your Comments:
(Date:3/28/2015)... Centurion Service Group will be hosting a ... 2 at their Las Vegas warehouse, located at 4606 Andrews ... which consists of equipment from hospitals and surgery centers from ... PDT. , Buyers will find items of all types ... a one-stop-shop,” said Erik Tivin, CEO of Centurion. , Among ...
(Date:3/28/2015)... Delaying rotator cuff surgery on patients ... research presented today at the American Orthopaedic Society for ... study compared results for 170 patients who received rotator ... joint capsule release procedure to relieve stiffness at the ... author from St. George Hospital in Sydney, Australia. “Both ...
(Date:3/28/2015)... 2015 Lately the student-athlete experience ... changes and proposals around the NCAA. In a March ... collegiate student-athletes across a spectrum of universities and sports ... challenges. The special panel consists of athletes who have ... from football, track and field, baseball, and volleyball. They ...
(Date:3/28/2015)... Viejo, California (PRWEB) March 28, 2015 ... announced a new overlay entitled Scratches 5K from Pixel ... grungy scratch effects to any media inside Final Cut ... Studios. “StoryBoard Corporate saves time and is an effective ... media using FCPX Overlay Scratches 5K's intuitive grunge overlays. ...
(Date:3/28/2015)... March 28, 2015 LTW Cyber is ... to collaborate for the purpose of addressing the needs ... will pursue its own opportunities to grow while seeking ... of LTW Cyber. , Ventures in LTW Cyber focus ... complemented by offerings identifying vulnerabilities and analyzing open source. ...
Breaking Medicine News(10 mins):Health News:Medical Equipment Auction to Take Place in North Las Vegas 2Health News:No Need to Delay Rotator Cuff Surgery, Study Shows 2Health News:SCI TV Panel of Former College Athletes Discusses Student Athlete Experience 2Health News:SCI TV Panel of Former College Athletes Discusses Student Athlete Experience 3Health News:Pixel Film Studios Unveiled Scratches 5k for Final Cut Pro X Editors 2Health News:Canadian Cybersecurity Ventures Globalize as a Collective 2Health News:Canadian Cybersecurity Ventures Globalize as a Collective 3
(Date:3/27/2015)... Zimmer Holdings, Inc. (NYSE and SIX: ZMH) is celebrating a ... Complete Knee System. , ... since Zimmer first introduced the NexGen knee system, with its ... five million implantations of the NexGen knee have taken place ... knee demonstrates the importance of design innovation and component quality for ...
(Date:3/27/2015)... 2015 XRpro Sciences, Inc., a provider ... development services which features high throughput transporter and ... financial results for the year ended December 31, ... of XRpro Sciences commented, "We have completed a ... stage to commercial stage in large part by ...
(Date:3/27/2015)... March 27, 2015 Report Details  ... leading ophthalmic drug companies  What does the ... ophthalmic industry ? Visiongain,s brand new report shows you ... prospects there. Our 242-page report provides 185 ... in the industry and the future market prospects. Our ...
Breaking Medicine Technology:Zimmer Celebrates Key Milestones For NexGen Complete Knee System 2XRpro Sciences Announces Fiscal 2014 Financial Results 2XRpro Sciences Announces Fiscal 2014 Financial Results 3XRpro Sciences Announces Fiscal 2014 Financial Results 4Pharma Leader Series: Top 25 Ophthalmic Drug Manufacturers 2015-2025 2Pharma Leader Series: Top 25 Ophthalmic Drug Manufacturers 2015-2025 3Pharma Leader Series: Top 25 Ophthalmic Drug Manufacturers 2015-2025 4Pharma Leader Series: Top 25 Ophthalmic Drug Manufacturers 2015-2025 5Pharma Leader Series: Top 25 Ophthalmic Drug Manufacturers 2015-2025 6Pharma Leader Series: Top 25 Ophthalmic Drug Manufacturers 2015-2025 7
Cached News: