HOME >> MEDICINE >> NEWS
Johns Hopkins scientists uncover clues to 'disappearing' precancers

New research sheds light on why cervical precancers disappear in some women and not in others. Scientists at the Johns Hopkins Kimmel Cancer Center report in the July 1 issue of Clinical Cancer Research that the reason many of these lesions persist is an unlikely mix of human papilloma virus (HPV) strain and a woman's individual immune system.

For decades, scientists have known that HPV causes nearly all cases of cancer in the neck of the womb. Most sexually active women some reports say up to 80 percent are exposed to HPV and more than half of these women are infected with strains of the virus that could likely turn a precancerous lesion to cancer. But only a small percentage of precancers progress to full-blown cancer, a process that takes years.

To find out why, gynecologic oncologist Cornelia Trimble, M.D., closely monitored 100 women with high-grade, precancerous cervical lesions before standard surgery to remove the abnormal tissue. Some of the lesions about 28 percent -- regressed by themselves before surgery within a time period considered within the bounds of care standards. But among patients whose pre-cancers lingered, Trimble discovered that women were three times less likely to resolve their lesions if they carried a certain immune system gene and did not have HPV16, the most common strain of the virus.

Trimble was particularly interested in these molecular differences because she is using HPV-targeted vaccines in related studies to treat early cervical lesions before they turn into cancer. "It's important for us to know the immunologic fingerprint of women who may best benefit from our vaccine," she says. "Some lesions are on the brink of resolving, but may need the vaccine to push them over."

Lesions containing HPV16 alone are the most troublesome and difficult to resolve. In the subset of 44 patients with HPV16 only, their type of immune system made no impact on whether or not their lesion resolved. But in
'"/>


1-Jul-2005


Page: 1 2

Related medicine news :

1. Johns Hopkins begins aggressive screening for superbugs in children
2. Johns Hopkins develops pancreas cancer risk model
3. March of Dimes, Johnson & Johnson Pediatric Institute launch prematurity prevention partnership
4. Diagnosis and referrals for kidney disease fall well short of need, Johns Hopkins study shows
5. Johns Hopkins Childrens Center to lead largest-ever study on kidney disease in children
6. Johns Hopkins lab scientists tame overactive CF protein
7. Two tests better than one for diabetes control, Johns Hopkins expert tells doctors
8. Johns Hopkins scientists exploit novel route to reverse enlarged hearts in obese mice
9. Johns Hopkins scientists map brain area that may aid hunt for human brain stem cells
10. Johns Hopkins study suggests link between caffeine dependence and family history of alcoholism
11. Johns Hopkins flu expert calls for mandatory vaccination of health care workers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/4/2020)... ... July 03, 2020 , ... The latest SARS-CoV-2 news, enabling ... Future Lab: COVID-19 R&D . , Future Lab is an interactive ... specific scientific niches. Since their launch four years ago, the Future Lab content ...
(Date:7/2/2020)... ... ... Dr. Christine Blaine has earned a stellar reputation as one of ... Island, Huntington and NYC, NY. Her former Manhattan clinic, located at 1201 Broadway, ... NYC at 160 Madison Avenue. Blaine Plastic Surgery will be one of ...
(Date:7/1/2020)... ... , ... Dexur’s analysis of Medicare claims of hospitals within a ... Hospital , and Sky Ridge Medical Center had the best value ... tracks a patient’s episode of care from the date of admission for 90 days ...
(Date:7/1/2020)... (PRWEB) , ... July 01, 2020 , ... ... today that it has been selected by Codiak BioSciences to support its cleanroom ... will provide the cleanroom infrastructure for the drug substance and product manufacturing for ...
(Date:6/28/2020)... ... June 26, 2020 , ... Recovery from drug ... residential addiction treatment center, proudly announces that it has reopened to serve new ... recovery in a world affected by Covid-19. , When social-distancing guidelines changed the ...
Breaking Medicine News(10 mins):
(Date:7/1/2020)... ... July 01, 2020 , ... The final entry ... is Tuesday, July 28. , The International Business Awards are widely ... competition attracted more than 4,000 nominations from organizations in more than 70 nations. ...
(Date:6/28/2020)... ... June 28, 2020 , ... Probiotics have long been ... effectiveness of oral-care probiotics to maximize teeth and gum health. What is ... is simple – utilizing naturally occurring positive bacteria to improve health - the ...
(Date:6/25/2020)... ... June 25, 2020 , ... R3 Medical Training announced today it is ... at several locations. The first course is August 6-7, 2020 in San Diego and ... offered as a Virtual Live Stream option. , The two day agenda for each ...
Breaking Medicine Technology:
Cached News: