Johns Hopkins team finds 'ancestral' hepatitis-C virus at the root of evolution in infections

amma would indicate, the scientists say, that the immune system was weakening in its response to the virus' mutations.

After analyzing the genetic changes in the sites, called epitopes, where the T cells specifically bind to the virus, the researchers found no changes had occurred during the one year of follow-up in the one patient who self-recovered. However, in the remaining seven patients, there were changes in 69 percent of T-cell epitopes, showing that the virus had mutated at key locations necessary for chronic infection to proceed.

Additional analysis showed that changes in T-cell epitopes were 13 times more frequent than changes in the remaining genome of the virus. The researchers examined the binding ability of T cells obtained early in infection to recognize 10 viral peptides known to have changed during the first six months of infection. Eight showed severely reduced capacity to stimulate production of interferon gamma, offering confirmation that the virus was mutating to evade the immune system.

Analysis of the viral RNA in the blood of seven patients with chronic infections revealed that eight of 16 changes in genome matched to the consensus sequence, confirming the presence of selective evolutionary pressure toward restoration of an ancestral form of the virus.

In the second study, using blood samples collected in Cork, Ireland, the researchers compared the genetic makeup of the virus in 22 chronically infected women to the original strain that had infected them more than 20 years before. The women were among hundreds accidentally infected in 1977 by a blood product tainted with hepatitis C, providing the researchers with unique access to the source of the infection, which came from a single donor unaware of having the illness.

Using computer analysis techniques developed at Hopkins, the scientists mapped these changes against the genetic makeup of the women's immune response. The researchers found th

Contact: David March
Johns Hopkins Medical Institutions

Page: 1 2 3 4 5 6

Related medicine news :

1. Johns Hopkins begins aggressive screening for superbugs in children
2. Johns Hopkins develops pancreas cancer risk model
3. March of Dimes, Johnson & Johnson Pediatric Institute launch prematurity prevention partnership
4. Diagnosis and referrals for kidney disease fall well short of need, Johns Hopkins study shows
5. Johns Hopkins Childrens Center to lead largest-ever study on kidney disease in children
6. Johns Hopkins lab scientists tame overactive CF protein
7. Two tests better than one for diabetes control, Johns Hopkins expert tells doctors
8. Johns Hopkins scientists exploit novel route to reverse enlarged hearts in obese mice
9. Johns Hopkins scientists map brain area that may aid hunt for human brain stem cells
10. Johns Hopkins study suggests link between caffeine dependence and family history of alcoholism
11. Johns Hopkins flu expert calls for mandatory vaccination of health care workers

Post Your Comments:

(Date:10/13/2015)... ... October 13, 2015 , ... ActivePDF, a leading provider of ... to batch conversions of CAD drawings, plans, and diagrams to PDF that ... eliminates the complexity requirement of specialized applications to view CAD designs. Converting to ...
(Date:10/13/2015)... ... October 13, 2015 , ... ... world’s first commercially-available next-generation sequencing laboratory test for bacterial vaginosis- a significant ... Obstetrics in Vancouver, BC, Canada. , In a presentation entitled: "The ...
(Date:10/12/2015)... , ... October 13, 2015 , ... ... its biannual Heroes in Recovery Awards at Foundations Recovery Network’s Moments of Change ... presented the one-of-a-kind awards to Noah Levine and Dean Dauphinais who exemplify the ...
(Date:10/12/2015)... ... ... article published October 6th by the Herald Tribune, a recent study that compared ... 1988 has shown that it really is more difficult to lose weight these days. Specifically, ... 1971 would be on average 10 pounds heavier than their past counterpart. In terms of ...
(Date:10/12/2015)... ... ... Amerec , a leader in the steam and sauna industry, and ... displaying custom sauna and steam room solutions at the ISPA Conference & Expo in ... SpaEquip is recognized for their ability to assist in the design and implementation of ...
Breaking Medicine News(10 mins):
(Date:10/12/2015)... 12, 2015  CME Group,s Center for Innovation ... of Theranos, is the 11 th recipient of the ... revolutionary blood diagnostics company, Theranos , to change health ... a new era of preventive care. CME Group will present ... Conference in Naples, Florida , on ...
(Date:10/12/2015)... , Oct. 12, 2015 ... -based medical technology company that designs ... announced today it has entered into a ... a company dedicated to producing devices, software ... health. SensiLase PAD-IQ®, developed and produced by ...
(Date:10/12/2015)... 2015  To help address the growing opioid epidemic ... Surgeons (AAOS) Board of Directors is calling for ... patient education; the tracking of opioid prescription use; research ... effective opioid abuse treatment programs. David Ring ... Safety Committee. "The new , AAOS Information Statement on ...
Breaking Medicine Technology:
Cached News: