HOME >> MEDICINE >> NEWS
Kidney-damaging protein offers clue to new treatment

CINCINNATI--Scientists led by a University of Cincinnati (UC) kidney expert have found that a naturally occurring protein that normally fights cancer cells can also cause severe kidney failure when normal blood flow is disrupted.

This finding, seen in mice in which the gene controlling the protein is actually expressed or "turned on," could provide a target for drugs that will reduce the risk of kidney damage in humans, the researchers believe.

Acute kidney failure is a life-threatening illness caused by sudden, severe loss of blood flow to the kidneys (ischemia). Despite advances in supportive care, such as dialysis, severe kidney injury is a major cause of death.

The scientists, headed by Manoocher Soleimani, MD, director of nephrology and hypertension at UC and the Cincinnati Veterans Affairs Medical Center, report their findings in the Dec. 1, 2005, issue of the Journal of Clinical Investigation.

The protein, thrombospondin (TSP-1), is known for its role in fighting cancer. It does this by killing off cancer cells and preventing the tumor from building a greater blood supply.

Although TSP-1 causes irreversible, severe kidney damage when blood flow to mouse kidneys is disrupted, the researchers say, this only occurs in animals whose TSP-1 gene is turned on.

The study showed that the protein damages kidney cells when blood flow is reduced for 30 minutes or more. When blood flow is restored to the kidneys, if TSP-1 protein is present, normal kidney function doesn't return.

"This raises the important possibility that TSP-1 may serve as a target in preventing or successfully treating acute kidney failure," said Dr. Soleimani. "Understanding the mechanisms of kidney cell injury moves us that much closer to preventing this life-altering damage from happening.

"If we can develop a drug that will inhibit or turn off the TSP-1 gene function, then severe kidney damage could be prevented--even during a 30
'"/>

Contact: Sheryl Hilton
sheryl.hilton@uc.edu
513-558-4561
University of Cincinnati
17-Nov-2005


Page: 1 2

Related medicine news :

1. Draining away brains toxic protein to stop Alzheimers
2. Penn study finds pro-death proteins required to regulate healthy immune function
3. Blocking stress protein decreases Alzheimers peptide in mice
4. Fat protein cuts blood vessel inflammation, may help heart, Jefferson scientists find
5. OHSU Cancer Institute researcher identifies protein marker for prostate cancer survival
6. Cow protein aids in treatment of gastrointestinal disorder
7. Study implicates protein as a trigger of advanced prostate cancer recurrence
8. Speeding fingertip discovery -- 20 years of protein info in 1 place
9. Head and neck cancer vaccine targets proteins to create immune response
10. Slick and springy: Brown research reveals proteins role in joints
11. Blocking immune cell action increases Alzheimers-associated protein deposits

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Kidney damaging protein offers clue new treatment

(Date:7/29/2015)... ... 29, 2015 , ... A June 10, 2015 article from the News-Press, entitled ... importance of having regular skin cancer screenings from an early age. Skin cancer can ... When caught early, skin cancer is rarely fatal; however, if left alone for too ...
(Date:7/29/2015)... (PRWEB) , ... July 29, 2015 , ... Employee Fiduciary, ... will include the general contact information, website, types of plans administered, years in business, ... business listing and have at least one plan with Employee Fiduciary. A search can ...
(Date:7/29/2015)... ... ... Several years ago, in order to be in the strongest position possible ... stance and began planning the Children’s Village consisting of six homes. , Two are ... third home. , “We are very pleased to have received the $500,000 grant from ...
(Date:7/29/2015)... St. Louis, MO (PRWEB) , ... July 29, 2015 , ... ... the website, the Talcum Powder Cancer Lawsuit Center. The website now features a page ... warnings, and news pieces from other sources. The Talcum Powder Lawsuit News ...
(Date:7/29/2015)... Canada (PRWEB) , ... July 29, 2015 , ... ... as a “forward thinker.” Since the late 1970s, Dr. Cottrell has been making ... new book, The New Earth, documents many of these prognostications. He warns that ...
Breaking Medicine News(10 mins):Health News:Get Checked for Skin Cancer Early and Often 2Health News:Get Checked for Skin Cancer Early and Often 3Health News:Employee Fiduciary Launches Financial Advisor Directory 2Health News:Little City Receives $500,000 Matching Grant from The Coleman Foundation 2Health News:Little City Receives $500,000 Matching Grant from The Coleman Foundation 3Health News:National Attorneys Provide Regular Talcum Powder Lawsuit News Updates 2Health News:National Attorneys Provide Regular Talcum Powder Lawsuit News Updates 3Health News:Author Warns Public to Prepare for Imminent Environmental Disaster 2
(Date:7/29/2015)... 29, 2015  Efforts to improve working capital efficiency ... firms in North America and ... an effective working capital management will ease the difficulties ... Big pharma companies expect to invest in optimizing working ... http://photos.prnewswire.com/prnh/20150724/241957LOGO Analysis from Frost ...
(Date:7/28/2015)... FRANCISCO , July 28, 2015 Codman ... Johnson, has introduced a new platform of embolic coils ... enhanced detachment system designed to improve microcatheter stability and ... The announcement was made here at the Society of ... The family of framing, filling and finishing coils ...
(Date:7/28/2015)... , July 28, 2015   Regulus Therapeutics Inc ... the discovery and development of innovative medicines targeting microRNAs, ... highlights for the quarter ended June 30, 2015 on ... close. Regulus will host a conference ... 5:00 pm Eastern Daylight Time to discuss its second ...
Breaking Medicine Technology:Working Capital Management Seizes Priority in North American and European Pharma Industry 2Working Capital Management Seizes Priority in North American and European Pharma Industry 3Working Capital Management Seizes Priority in North American and European Pharma Industry 4Codman Neuro Launches Family Of Coils For Treatment Of Brain Aneurysms 2Codman Neuro Launches Family Of Coils For Treatment Of Brain Aneurysms 3Codman Neuro Launches Family Of Coils For Treatment Of Brain Aneurysms 4Regulus Announces Timing for Second Quarter 2015 Financial Results Webcast and Conference Call 2Regulus Announces Timing for Second Quarter 2015 Financial Results Webcast and Conference Call 3
Cached News: