HOME >> MEDICINE >> NEWS
Kidney-damaging protein offers clue to new treatment

CINCINNATI--Scientists led by a University of Cincinnati (UC) kidney expert have found that a naturally occurring protein that normally fights cancer cells can also cause severe kidney failure when normal blood flow is disrupted.

This finding, seen in mice in which the gene controlling the protein is actually expressed or "turned on," could provide a target for drugs that will reduce the risk of kidney damage in humans, the researchers believe.

Acute kidney failure is a life-threatening illness caused by sudden, severe loss of blood flow to the kidneys (ischemia). Despite advances in supportive care, such as dialysis, severe kidney injury is a major cause of death.

The scientists, headed by Manoocher Soleimani, MD, director of nephrology and hypertension at UC and the Cincinnati Veterans Affairs Medical Center, report their findings in the Dec. 1, 2005, issue of the Journal of Clinical Investigation.

The protein, thrombospondin (TSP-1), is known for its role in fighting cancer. It does this by killing off cancer cells and preventing the tumor from building a greater blood supply.

Although TSP-1 causes irreversible, severe kidney damage when blood flow to mouse kidneys is disrupted, the researchers say, this only occurs in animals whose TSP-1 gene is turned on.

The study showed that the protein damages kidney cells when blood flow is reduced for 30 minutes or more. When blood flow is restored to the kidneys, if TSP-1 protein is present, normal kidney function doesn't return.

"This raises the important possibility that TSP-1 may serve as a target in preventing or successfully treating acute kidney failure," said Dr. Soleimani. "Understanding the mechanisms of kidney cell injury moves us that much closer to preventing this life-altering damage from happening.

"If we can develop a drug that will inhibit or turn off the TSP-1 gene function, then severe kidney damage could be prevented--even during a 30
'"/>

Contact: Sheryl Hilton
sheryl.hilton@uc.edu
513-558-4561
University of Cincinnati
17-Nov-2005


Page: 1 2

Related medicine news :

1. Draining away brains toxic protein to stop Alzheimers
2. Penn study finds pro-death proteins required to regulate healthy immune function
3. Blocking stress protein decreases Alzheimers peptide in mice
4. Fat protein cuts blood vessel inflammation, may help heart, Jefferson scientists find
5. OHSU Cancer Institute researcher identifies protein marker for prostate cancer survival
6. Cow protein aids in treatment of gastrointestinal disorder
7. Study implicates protein as a trigger of advanced prostate cancer recurrence
8. Speeding fingertip discovery -- 20 years of protein info in 1 place
9. Head and neck cancer vaccine targets proteins to create immune response
10. Slick and springy: Brown research reveals proteins role in joints
11. Blocking immune cell action increases Alzheimers-associated protein deposits

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Kidney damaging protein offers clue new treatment

(Date:3/3/2015)... Burlington, VT (PRWEB) March 03, 2015 In ... world’s largest environmental networks, will kick off a new campaign, ... join the network’s businesses, nonprofits, and ambassadors in their quest ... Planet will work with several of its members and partners, ... Johnson’s All At Once network, to raise awareness for food ...
(Date:3/3/2015)... (PRWEB) March 04, 2015 The report ... on the therapeutic development for Alopecia. Alopecia is the ... the two main types of alopecia. Causes for alopecia ... Symptoms of alopecia may include male pattern hair loss, ... hair. Alopecia can be classified as focal or diffuse ...
(Date:3/3/2015)... (PRWEB) March 03, 2015 US Air ... efficiency air purification systems, is pleased to announce that all ... brief supply interruption related to the west coast port strikes. ... just around the corner. , The port ... expected to slow fourth quarter economic growth by as much ...
(Date:3/3/2015)... NY (PRWEB) March 03, 2015 Daylight Savings ... spring. Sanjeev Kothare, MD, has tips for parents. , Parents ... March 8 at 2:00 a.m. when they set their clocks ... you wake up that day -- one hour earlier -- ... That’s why parents should start thinking about “sleep hygiene” for ...
(Date:3/3/2015)... Topical BioMedics, Inc., announces its March Pain ... on Tuesday, March 10th, 12pm – 1pm and 4pm to ... 24/7. , The Pain Management Workshops are ... March 10th workshop is “Opioid Addiction: An Over-Medicated Society.” ... represents 5% of the world’s population, yet consumers 99% of ...
Breaking Medicine News(10 mins):Health News:1% For the Planet Asks Consumers to “Know Your Source” 2Health News:Alopecia Therapeutics Drugs and Companies Pipeline Market H1 2015 Review Report Available at RnRMarketResearch.com 2Health News:Alopecia Therapeutics Drugs and Companies Pipeline Market H1 2015 Review Report Available at RnRMarketResearch.com 3Health News:Alopecia Therapeutics Drugs and Companies Pipeline Market H1 2015 Review Report Available at RnRMarketResearch.com 4Health News:Rabbit Air Purifiers Back In Stock at US Air Purifiers LLC 2Health News:Rabbit Air Purifiers Back In Stock at US Air Purifiers LLC 3Health News:Don’t Let Daylight Savings Disrupt Your Child’s Sleep 2Health News:Topical BioMedics Hosts March Pain Management Webinar 2Health News:Topical BioMedics Hosts March Pain Management Webinar 3Health News:Topical BioMedics Hosts March Pain Management Webinar 4Health News:Topical BioMedics Hosts March Pain Management Webinar 5
(Date:3/3/2015)... - CPhI and P-MEC China 2015 ... Shanghai, China - The 15th CPhI ... at Shanghai New International Expo Center, on 24th June, 2015. ... and was introduced to China in 2001. It has successfully ... and global pharmaceutical industry over the past 15 years. With ...
(Date:3/3/2015)... NEW YORK , March 3, 2015 /PRNewswire/ ... biopharmaceutical company advancing protein biologic therapies and oncology supportive ... 27 th Annual ROTH Capital Partners Conference which ... Ritz-Carlton, Laguna Niguel in Dana Point, California.  ... is scheduled to present a corporate update on Wednesday, ...
(Date:3/3/2015)... Mar. 03, 2015 Research and Markets ... PharmaBiotech,s new report "Cardiovascular Drug Delivery - Technologies, ... Drug delivery to the cardiovascular system is ... anatomy and physiology of the vascular system; it supplies ... Drugs can be introduced into the vascular system for ...
Breaking Medicine Technology:15th Anniversary, Be Part of Chinese Pharma Dream 215th Anniversary, Be Part of Chinese Pharma Dream 3PlasmaTech Biopharmaceuticals To Present at 27th Annual ROTH Capital Partners Conference 2Global Cardiovascular Drug Delivery Technologies, Markets and Companies 2014-2024 2Global Cardiovascular Drug Delivery Technologies, Markets and Companies 2014-2024 3
Cached News: