HOME >> MEDICINE >> NEWS
Lack of response to herceptin may be reversed with addition of a PI3K inhibitor

Washington, D.C. - Breast cancer patients with HER2-positive tumors who don't respond to Herceptin (trastuzumab) may benefit from cocktail therapy that includes Herceptin along with one or more PI3K inhibiting agents, say researchers at The University of Texas M. D. Anderson Cancer Center.

Their findings, reported at the annual meeting of the American Association for Cancer Research (AACR), were made in cell culture and mice studies, but are so promising that a Phase I/II clinical trial will start at M. D. Anderson in HER2-positive breast cancer patients whose disease has progressed despite Herceptin treatment.

"More than half of patients with HER2-positive tumors don't respond to Herceptin as a single agent, and our research has shown us why that is and what might be done to help these patients," says the study's lead author, Dihua Yu, M.D., Ph.D., professor in the Department of Surgical Oncology. Yu will discuss these findings at an AACR press briefing on Wednesday, April 5, at 9 a.m.

"If this drug cocktail shows benefit, we hope to be able to identify those patients who won't respond to Herceptin before they start the treatment, and offer them a new and beneficial drug combination," Yu says. "Patients who don't respond to Herceptin have worrisome outcomes, so we hope this strategy will help them."

Combining PI3K inhibitors with existing therapies also might provide additional benefit in treating other breast tumor types.

In 2004, Yu and her research team reported that patients who don't respond to Herceptin have very low levels of PTEN in their breast tumors, whereas women who respond have higher levels of this protein. In normal cells, PTEN is a powerful tumor suppressor gene that helps control cell division. In about half of all of breast tumors (HER2-positive or not), however, PTEN levels are very low or the protein is completely missing.

It was known that when Herceptin, a monoclonal antibody, binds to the HER-2
'"/>

Contact: Nancy Jensen
nwjensen@mdanderson.org
713-745-1584
University of Texas M. D. Anderson Cancer Center
4-Apr-2006


Page: 1 2 3

Related medicine news :

1. A new direction: Integrating best-practices to improve food responses
2. Childrens brain responses predict impact of sleep loss on attention
3. Dasatinib shows high early response rate as first treatment for chronic myelogenous leukemia
4. Bali bomb lessons helped shape Australias mental health response to terrorism and trauma
5. Public health impact of climate change, poverty, disaster response and housing design
6. Low-glycemic load diet may be more effective for dieters with certain insulin response patterns
7. Faster and better emergency response through satellite telecoms
8. Culture sculpts neural response to visual stimuli, new research indicates
9. Study finds role of mid-brain in integrating heart and respiratory response to exercise
10. Does a peptide affect the hearts response to social isolation?
11. Head and neck cancer vaccine targets proteins to create immune response

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/18/2019)... ... April 18, 2019 , ... Arnet ... concentration, memory, relaxation and restful sleep to support a healthy mind and body. ... mental clarity, focus and vitality. , The portfolio includes a total of ten ...
(Date:4/18/2019)... NORTHBROOK, Ill. (PRWEB) , ... April 18, 2019 , ... ... tests” and a pair of eyeglasses, said her mother, Cheryl Reilly. Those “goofy tests,” ... Ill., suggested that Mikayla Reilly, then 12 years old, had such narrow range of ...
(Date:4/18/2019)... DIEGO (PRWEB) , ... April 18, 2019 , ... ... is releasing its first ever Cannabis Industry Report . The study—which considers ... cannabis’s emerging intersections with retail and manufacturing, offering insight into what kinds of ...
(Date:4/17/2019)... ... ... Kadan Homecare, an award-winning provider of quality, non-medical home care to Atlanta area families ... of Home Care® – Provider of Choice and Employer of Choice Awards from Home ... on client and caregiver satisfaction scores gathered by Home Care Pulse. Kadan is now ...
(Date:4/17/2019)... ... April 17, 2019 , ... ... reduce hangover symptoms. This California-made supplement was designed to lessen the negative ... now available for purchase via GotPurpleTree.com and Amazon.com . , ...
Breaking Medicine News(10 mins):
(Date:4/17/2019)... ... April 17, 2019 , ... ... antibodies, kits, and services, today announced that they have formalized partnerships with ... that encourage science and environmental education, arts, and support for the underprivileged ...
(Date:4/17/2019)... ... , ... Clinical trials of new cancer treatments have historically focused on disease ... advances in medical oncology and genomic characterization of tumors, we are now able to ... “basket trials.” This ability has created a paradigm shift in oncology trials. , In ...
(Date:4/17/2019)... Mass. (PRWEB) , ... April ... ... dba MyMedicalShopper , a leading provider of healthcare price transparency solutions, ... based in Massachusetts, are partnering to give consumers more choice and control ...
Breaking Medicine Technology:
Cached News: