Lag-time often occurs before new treatments for pediatric HIV infectio...( There often is a short lag between the ...)

Lag-time often occurs before new treatments for pediatric HIV infection are used

There often is a short lag between the release of a new treatment for pediatric HIV infection and its implementation in the community, according to a study in the May 11 issue of JAMA.

Antiretroviral therapy (ART) for pediatric human immunodeficiency virus (HIV) infection has evolved from the single or dual nucleoside reverse transcriptase inhibitor (NRTI) regimens of the 1980s and early 1990s to today's complex regimens of NRTI in combination with protease inhibitors (PIs) and/or nonnucleoside reverse transcriptase inhibitors (NNRTIs), according to background information in the article. No previous studies have examined how novel therapies have been integrated into the clinical care of pediatric HIV infection, or if there is concordance between recommended guidelines and treatment in clinical practice.

Susan Brogly, Ph.D., of the Harvard School of Public Health, Boston and colleagues examined the changes in the treatment of pediatric HIV in the United States from 1987 to 2003. The study included 766 perinatally HIV-infected children from the Pediatric AIDS Clinical Trials Group 219C cohort born before January 1, 2004, who had not participated in an ART clinical trial.

The researchers found that single and dual NRTI regimens were used most frequently through 1997. In 1998, 2 years after protease inhibitors were approved for adult HIV infection and at the time pediatric guidelines were issued, regimens of highly active antiretroviral therapy including a protease inhibitor became most frequently used. From 1998-2003, 22 percent of children initiated ART with a regimen not recommended by pediatric guidelines. In additional analysis, the risk of switching decreased with age at ART initiation and increased with year of initiation. The risk of switching was higher in children who started with 1 or 2 NRTIs or an unconventional regimen vs. children who started on a protease inhibitor-containing regimen.

"The use of unorthodox regimen
'"/>

Contact: Kevin Myron
617-432-3952
JAMA and Archives Journals
10-May-2005

Page: 1 2
Related medicine news :

1. A broader look at cardiac CTA images often finds diseases/disorders beyond the heart
2. Students with symptoms of mental illness often dont seek help
3. Physician-researchers often less successful in obtaining NIH funding
4. New mothers often not asked about depression, UNC survey finds
5. Children with both autism and ADHD often bully, parents say
6. Family members most often source of whooping cough in young infants
7. Uninsured often receive less medical care, take longer to improve after sudden health change
8. Anxiety disorders surprisingly common yet often untreated
9. Pediatric specialists often far from home
10. Vision and hearing loss often occur together in older age
11. Depressed stroke patients often not treated for depression

Post Your Comments: