HOME >> MEDICINE >> NEWS
Large-scale cross-platform study of research microarrays uncovers high concordance across platforms

BOSTON--Gene expression microarrays have made a profound impact on biomedical research. The current expectation is that this technology will extend its current role as an experimental tool for basic science research and be increasingly applied in clinical practice. Before this can occur, the issues of cross-platform comparison and integration of data must be addressed. The diversity of available platforms and analytical methods has made comparison of data from multiple platforms challenging. Different laboratories may use different platforms to profile the same genes, but how comparable are they?

Winston Patrick Kuo, DDS, MS, DMSc, post-doctoral researcher in the Department of Oral and Developmental Biology at the Harvard School of Dental Medicine, and colleagues tested nearly all the available commercial and "in-house" gene expression microarray platforms for cross-platform and cross-laboratory comparisons. They have produced a framework for comparisons across platforms and different laboratories, reported in the July 2 online edition of Nature Biotechnology.

This study comes on the heels of several large efforts to create standardized protocols for microarray experiments (from probe annotation to data analysis), such as the Minimum Information About a Microarray Experiment (http://mged.org/Workgroups/MIAME/miame.html), the External RNA Controls Consortium (http://www.cstl.nist.gov/biotech/Cell&TissueMeasurements/GeneExpression/ERCC.htm), and the Microarray Quality Control Project (http://www.fda.gov/nctr/science/centers/toxicoinformatics/maqc/). In addition, major portals for deposition and retrieval of microarray data, such as the Gene Expression Omnibus and ArrayExpress, will only be truly useful if experiments a
'"/>

Contact: Leah Gourley
public_affairs@hms.harvard.edu
617-432-0442
Harvard Medical School
2-Jul-2006


Page: 1 2 3 4

Related medicine news :

1. Large-scale study proves volunteer operated defibrillators are life-savers
2. Large-scale trial indicates no benefit from low-dose aspirin in preventing cancer in healthy women
3. Large-scale study identifies key stress factors facing new mums
4. Childhood obesity indicates greater risk of school absenteeism, Penn study reveals
5. Penn study finds pro-death proteins required to regulate healthy immune function
6. New study shows promise in reducing surgical risks associated with surgical bleeding
7. New study counts the economic cost of persistent pain in Australia
8. UCLA researchers awarded $9M contract for study identifiying antibiotic treatment for MRSA
9. Most seniors now have drug coverage, U-M study shows
10. To gain muscle and lose fat, drink milk: study
11. Wheres the beef? Not enough of it is on elders plates, muscle-metabolism study suggests

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/2/2020)... ... April 02, 2020 , ... FDA ... Webinar, Tuesday April 7, 2020, 1:30-3:00 p.m. EDT, https://www.fdanews.com/cdssoftwareregulation ... AI used to guide clinical management of the Coronavirus.* , Is one’s software ...
(Date:4/2/2020)... , ... April 02, 2020 , ... Since the onset ... food safety standards and practices. GoParrot ( https://www.goparrot.ai/ ) founder Yaniv Nissim has ... specialize in virus control and food safety, has created new standards for delivering food ...
(Date:4/1/2020)... ... April 02, 2020 , ... Medical Device Change Management, An ... https://www.fdanews.com/mdchangemanagement , What change management method should one be using for a ... dependent on the type of change. Is it due to post-market design change, production ...
(Date:4/1/2020)... ... April 01, 2020 , ... Velocidy Bio ’s ... revolutionary NEXTGENPCR that decreases the testing time for SARS-CoV-2 to eight minutes, ... unit the size of a shoebox could perform a hundred and eighty (180) amplification ...
(Date:3/30/2020)... ... March 30, 2020 , ... Achieve ... continuing its commitment to provide comprehensive and compassionate mental health and wellness services ... Medical Center’s UpDox platform for telemedicine services including initial consultations, evaluations, and follow-up ...
Breaking Medicine News(10 mins):
(Date:4/2/2020)... ... April 02, 2020 , ... NCPDP has elected its ... Meeting of the NCPDP Board of Trustees on Wednesday, May 6, 2020. , ... M.B.A., PBM Practice Lead, Point-of-Care Partners, newly elected to the Board of Trustees. , ...
(Date:4/2/2020)... ... 02, 2020 , ... On April 15, the Center for ... annual Medical Hero Appreci-a-thon to bring the global clinical research community together to ... and study volunteers. CISCRP invites the public to participate in this free ...
(Date:4/1/2020)... ... April 01, 2020 , ... As the coronavirus pandemic ... care and accessible primary care, launches its telemedicine platform, AFC/TeleCare, as a solution ... now provide virtual visits, allowing our medical providers to easily connect with patients ...
Breaking Medicine Technology:
Cached News: