Large-scale trial indicates no benefit from low-dose aspirin in preventing cancer in healthy women

A major study that includes nearly 40,000 healthy women found no benefit on preventing cancer from taking low-dose aspirin, or benefit on preventing cancer or cardiovascular disease from taking vitamin E, according to two articles in the July 6 issue of JAMA.

A growing body of literature has supported a protective effect of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) on the development of cancer, according to background information in the first article. Observational epidemiological investigations suggest a strong inverse association, with risk reductions as high as 20 percent to 50 percent for various cancer sites. In contrast with the observational evidence on cancer incidence, data from randomized trials, which provide more definitive results due to their ability to minimize bias and confounding, have been far more limited. The Physicians' Health Study (PHS) found no effect on colorectal cancer of 325 mg aspirin administered every other day over a 5-year randomized period or in post trial follow-up. In addition, no randomized trial has yet assessed the impact of aspirin on the development of breast cancer.

The Women's Health Study (WHS) was a randomized, double-blind, placebo-controlled trial, conducted between September 1992 and March 2004, evaluating the balance of benefits and risks of 100 mg of aspirin every other day, and 600 IU of vitamin E every other day on the primary prevention of cardiovascular disease and cancer in a cohort of 39,876 healthy female health care professionals over an average duration of 10.1 years.

In the first article, Nancy R. Cook, Sc.D., of Brigham and Women's Hospital and Harvard Medical School, Boston, and colleagues evaluated the findings for the aspirin component of the WHS with regard to cancer risk. In this part of the study, 19,934 women received a dose of 100 mg of aspirin every other day and 19,942 women received placebo.

The researchers found that aspirin had n

Contact: Melanie Franco
JAMA and Archives Journals

Page: 1 2

Related medicine news :

1. Large-scale cross-platform study of research microarrays uncovers high concordance across platforms
2. Large-scale study proves volunteer operated defibrillators are life-savers
3. Large-scale study identifies key stress factors facing new mums
4. New contracts support clinical trials on antibiotic-resistant, community-acquired staph infections
5. Warfarin better than aspirin at stroke prevention in elderly people with atrial fibrillation
6. Helicopter flight trials for EGNOS
7. Stroke in nonvascular atrial fibrillation -- anti-coagulants better than anti-platelet therapy
8. GSK announces launch of largest ever Phase III trial in lung cancer treatment
9. Bias in statin trials, failure to control malaria, and more
10. International journal group updates guidelines on registration of clinical trials
11. Clinical trial data for Perforomist Inhalation Solution presented at International ATS Conference

Post Your Comments:

(Date:3/30/2021)... , ... March 29, 2021 , ... ... the 21st Century , A Virtual Workshop Presented by WCG FDAnews and Cerulean ... 4:30 pm EDT, https://wcg.swoogo.com/modern-sop-and-quality-systems , Are one’s SOPs written for the ...
(Date:3/30/2021)... ... March 29, 2021 , ... According to data released ... reproductive age (13-44) in need of publicly funded contraception live in counties impacted by ... Colorado’s 64 counties have lost some of their Title X resources. , The ...
(Date:3/30/2021)... ... March 29, 2021 , ... Health Literacy Innovations (HLI), a ... confusion due to low health literacy today announces a new partnership with the ... work with ACAP’s member Safety Net Health Plans, those that provide comprehensive health ...
(Date:3/30/2021)... ... ... Dr. Colin Campbell is proud to announce the 1 year anniversary in their new state ... internal medicine and is a primary care specialist who has been practicing for 23 years. ... keep South Jersey healthy one patient at a time. , “Over the past year, Dr. ...
(Date:3/30/2021)... ... March 30, 2021 , ... The COVID-19 ... and survivors; their families; and their caregivers. Crossroads4Hope is addressing the needs of ... emotional support system, MyGo2Support, which meets needs of people impacted by cancer, no ...
Breaking Medicine News(10 mins):
(Date:3/30/2021)... ... March 29, 2021 , ... The University of Texas Health Science Center ... San Antonio Multispecialty and Research Hospital, a destination center for research and treatment of ... In a nod to the COVID-19 pandemic, the ceremony was held virtually. , William ...
(Date:3/30/2021)... ... March 29, 2021 , ... Iora Health ... primary care, has partnered with Devoted Health , one of the fastest-growing ... across Maricopa County and provides seniors with the highest-quality care and experience possible, ...
(Date:3/30/2021)... CITY (PRWEB) , ... March 29, 2021 , ... ... has joined the Vaccine Credential Initiative (VCI), a group bringing together leading health ... record of vaccination status, based on open, interoperable standards. By joining the VCI ...
Breaking Medicine Technology:
Cached News: