Leading advocates express support for microbicide research, despite disappointing trial results

HIV prevention advocates from three major civil society organizations today emphasized the importance of continued research into new HIV prevention options, despite the recent discontinuation of the Phase III effectiveness trials of the microbicide candidate, cellulose sulfate (CS).

CS was one of the four microbicide candidates in Phase III effectiveness trials for prevention of HIV and other sexually transmitted infections. CONRAD, a reproductive health research organization, was conducting Phase III trials to assess its effectiveness in Benin, India, South Africa, and Uganda. Another Phase III trial of CS sponsored by Family Health International was underway in Nigeria. Both sponsors are not-for profit research groups dedicated to advancing health in developing countries.

At the recommendation of their respective Data Safety Monitoring Boards both sponsors chose to discontinue their CS trials after findings from the CONRAD trial suggested that CS might be contributing to an increased risk of HIV infection. Although review of the data from the Nigerian trial found no evidence of increased risk, FHI felt that the only responsible course of action was to halt its study also.

"Of course we wish the results had been different, but learning what doesn't work can be just as important to progress as learning what does work," observed Lori Heise, Director of the Global Campaign for Microbicides (GCM). "It's also reassuring that the independent Data Safety and Monitoring Committees, put in place to identify problems early on in a trial, appear to have worked well. Advocates have been instrumental in pushing for extra mechanisms to help protect participant safety."

African advocates are following the trials conducted in their countries particularly closely, reported Manju Chatani, Coordinator of the African Microbicide Advocacy Group (AMAG). "Scientists scrutinized the data available on cellulose sulfate before the Phase III trials s

Contact: Lori Heise
AIDS Vaccine Advocacy Coalition (AVAC)

Page: 1 2 3

Related medicine news :

1. Leading prevention researchers meeting in Washington, D.C., May 30-June 1, 2007
2. Leading European experts in magnetic resonance for animals
3. Leading healthcare authorities to address safety and effectiveness
4. Leading international osteoporosis experts to present at worlds largest osteoporosis congress
5. Leading hepatology textbook edited by SLU researchers
6. Leading groups offer NIH direct links to journals to make research access easy for public
7. Leading immunosuppressant CellCept significantly extends the lifespan of transplanted kidneys
8. Leading pediatricians group recommends infants sleep in cribs, not parents beds
9. Leading genomic technology expert to present Dickson Prize Lecture at Pitt
10. Leading experts discuss how to protect premature infants against RSV, a potentially dangerous virus
11. Leading sleep expert at Wake Forest to speak at NIH Consensus Conference

Post Your Comments:

(Date:8/14/2019)... ... August 14, 2019 , ... Inc. magazine today revealed that RKC Products, a ... the most prestigious ranking of the nation’s fastest-growing private companies. With 200% revenue growth ... in the Health sector. The list represents a unique look at the most successful ...
(Date:8/14/2019)... Nev. (PRWEB) , ... August 13, 2019 , ... In ... and the purpose of doubt in your belief systems. , “Doubt can obliterate your ... start on the path to examining them to expand your understanding and your awareness. ...
(Date:8/12/2019)... ... August 12, 2019 , ... Cryotherapy has recently been the target of negative ... However, the cause of Brown’s injury was not due to cryotherapy, but due to ... NFL teams, such as the Dallas Cowboys, the Washington Redskins, the Denver Broncos and ...
(Date:8/9/2019)... ... , ... The Los Angeles employment law lawyers at Blumenthal Nordrehaug Bhowmik ... Food Markets, Inc., failed to provide their California employees with meal and rest periods ... lawsuit, Case No. 19STCV26728, is currently pending in the Los Angeles County Superior Court ...
(Date:8/9/2019)... ... August 08, 2019 , ... Guruji Mahendra Trivedi ... affecting humanity at practical and spiritual levels. , Founder of the Trivedi ... the God of their understanding, as well as, to illuminate the path of ...
Breaking Medicine News(10 mins):
(Date:8/16/2019)... ... August 16, 2019 , ... SignatureCare Emergency ... residents of Houston, TX including Montrose, Heights, Memorial City, and Bellaire, TX. , ... in Houston Heights, is aimed at helping Houston families get their children caught ...
(Date:8/16/2019)... , ... August 16, 2019 , ... ... Innovator, Tricia Lee (Wilkins) Rolle, PharmD, PhD, has joined the company as a ... with public and private sectors and industry standards organizations to advance use of ...
(Date:8/15/2019)... ... , ... On Sunday, August 4th, volunteers from Bright Now!® Dental ... the South LA community. Six doctors joined with their dedicated support staff to provide ... more at the South Gate Day of Giving. , Over 50 individuals were ...
Breaking Medicine Technology:
Cached News: