Dr. Davis is one of four prominent scientists who will present keynote lectures during the two-day event, which is scheduled Oct. 6 and 7. All Science2005 events are free and open to the public.
The Dickson Prize in Medicine, the most prestigious award presented by the University of Pittsburgh School of Medicine, recognizes individuals who have made significant, progressive contributions to the field of medicine. Established in 1969 by the estates of Joseph Z. Dickson, M.D., and his wife, Agnes Fischer Dickson, the prize consists of a bronze medal and an award of $50,000.
Dr. Davis's presentation, titled "New Genomic Technology for Yeast Applied to Clinical Medicine," is based on his research on more than 5,000 strains of Saccharomyces cerevisiae (baker's yeast) that he constructed by deleting a different yeast gene in each strain.
Dr. Davis's work has led to a number of important techniques that have advanced the exploration of RNA and DNA in the laboratory setting. Early in his career, Dr. Davis developed the quantitative analysis of DNA by electron microscopy as well as the R-loop technique for mapping coding RNAs by electron microscopy. This R-loop technology enabled the discovery of RNA splicing. Dr. Davis was instrumental in developing phage lambda-based cloning vectors and showed how they could be used for large capacity cloning with both bacterial and eukaryotic DNA. He also contributed significantly to the early development of recombinant DNA methods and extended these methods into