HOME >> MEDICINE >> NEWS
Life-threatening lupus responds to stem cell transplant therapy

Transplanting patients with blood stem cells that originate from their own bone marrow can induce the remission of life-threatening, treatment-resistant lupus, according to a study that took place at Northwestern Memorial Hospital in Chicago. Researchers found that 50 percent of the 50 patients in the study had disease-free survival at five years with an overall five-year survival rate of 84 percent. The study is published in the February 1 issue of the Journal of the American Medical Association.

Lupus, an autoimmune disease in which immune cells attack an individual's own organs, affects an estimated 1.5 million people, mostly young females. "For this study, we enrolled patients who had either life- or organ-threatening lupus and had exhausted all available treatment options," says lead author Richard Burt, MD, chief, Division of Immunotherapy for Autoimmune Diseases, Northwestern Memorial Hospital in Chicago and associate professor of Medicine at Northwestern University's Feinberg School of Medicine. "We found that within an experienced center, high-dose chemotherapy and autologous stem cell transplant may be performed safely and result in disease remission and improvement or salvage of residual organ function in the majority of patients."

The study, which was launched in 1997 when Dr. Burt performed the country's first stem cell transplant to treat lupus, enrolled 50 patients from 20 states and ran through January 2005. The authors conclude that that the findings provide the justification to launch a randomized study that would compare autologous stem cell transplant with continued standard of care.

The stem cell transplant process used in the study is similar to that done to treat some forms of cancer. The patients' own bone marrow stem cells were harvested from their blood. These cells, which can become different kinds of blood and immune system cells in the body, were then separated from the other blood cells. Next, in a p
'"/>

Contact: Amanda Widtfeldt
awidtfel@nmh.org
312-926-2955
Northwestern Memorial Hospital
31-Jan-2006


Page: 1 2 3

Related medicine news :

1. Medicaid patients with lupus travel farther to see specialists
2. Older, lower income patients least likely to see a specialist for lupus
3. Involvement of the amygdala in systemic lupus erythematosus
4. Spleen may be target of successful therapy for lupus
5. UT Southwestern researchers identify roles of gene mutations causing lupus in mice
6. Anti-malarials most effective in lupus patients genetically at risk of high levels of TNF-alpha
7. Research shows promise for using stem cell transplantation to treat patients with severe lupus
8. Study demonstrates safety of oral contraceptives in women with lupus
9. Clinical trial supports better treatment for lupus nephritis
10. Research published in the NEJM challenges 30-year-old standard of care for lupus patients
11. Common anti-seizure drug could be effective for lupus patients

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/23/2017)... ... July 23, 2017 , ... Technology is ... and patient-provider relationships. New tools are helping patients become more actively involved in ... Health Care’s Most Wired® survey, released today by the American Hospital Association’s (AHA) ...
(Date:7/23/2017)... ... July 23, 2017 , ... Longtime ... Relief Group – Melbourne, a practice owned by Physician Partners of America at ... management, Dr. Stern also is certified in pediatrics, emergency medicine and anesthesiology. , ...
(Date:7/23/2017)... , ... July 23, 2017 , ... ... announce today the grant of US Patent No. 9,038,640 by the United States ... technology and brings together the combination of Switching, Vacuum, and Cooling mechanisms to ...
(Date:7/22/2017)... CANADA (PRWEB) , ... July 22, 2017 , ... ... place each year with the majority of patients not requiring pain medication after ... Society for Sports Medicine’s Annual Meeting today in Toronto, Ontario, Canada found ...
(Date:7/21/2017)... ... July 21, 2017 , ... "As a doctor of lung medicine managing chest ... on the market," said an inventor from Center Valley, Pa. "My idea is to ... , He developed the patent-pending PLEURAL SAFE-t-STAT CATHETER KIT to offer an efficient means ...
Breaking Medicine News(10 mins):
(Date:7/14/2017)... , July 14, 2017 Endo International plc (NASDAQ: ... Tuesday, August 8, 2017.  Members of its senior management team will ... open at 8:30 a.m. ET. The dial-in number ... 497-0462, International (678) 509-7598, and the passcode is 45397076. Please dial ... A replay of the call will ...
(Date:7/13/2017)... , July 13, 2017  Centurion Medical Products, a leader in ... DisImpactor ® fecal impaction removal device for hospice patient care. ... Centurion Medical ... Patient pain management and emotional comfort ... can help alleviate patient pain while preventing unneeded emergency department admission ...
(Date:7/13/2017)... ROCKVILLE, Md. , July 13, 2017  New York ... watchers of pharmaceutical markets should be aware of.  From new ... These trends are detailed in a recently completed study, ... following: 1.  Age-Driven ... years, we have been aware of the impact the growing ...
Breaking Medicine Technology:
Cached News: