HOME >> MEDICINE >> NEWS
Little evidence behind bronchodilator therapy for cystic fibrosis

Little evidence exists to support the widespread use of bronchodilators to treat children and adults with cystic fibrosis, according to a new systematic review of published research.

"Recurrent wheeze and breathlessness are common in people with cystic fibrosis, and bronchodilators are commonly prescribed," according to lead author Clare Halfhide, M.D., of the Royal Liverpool Children's Hospital in England. "Despite their wide-scale and often long-term use, there is limited objective evidence about their efficacy in cystic fibrosis."

The review appears in the current issue of The Cochrane Library, a publication of The Cochrane Collaboration, an international organization that evaluates medical research. Systematic reviews draw evidence-based conclusions about medical practice after considering both the content and quality of existing medical trials on a topic.

Cystic fibrosis is a genetically inherited disease afflicting the lungs and the digestive system, the result of both parents passing on an abnormal gene. It is chronic, progressive and ultimately fatal.

Cystic fibrosis causes the exocrine glands, which produce sweat and mucus, to produce thick mucus that clogs the lungs, causing chronic respiratory difficulties. The mucus also obstructs pancreatic ducts, preventing digestive enzymes from reaching the intestines. Consequently, people with cystic fibrosis have difficulties breathing, absorbing nutrients and eliminating non-digested food.

The Cochrane review included 14 trials randomized controlled trials comprising 257 participants with cystic fibrosis.

Several trials compared inhaled bronchodilator drugs to placebo by looking at two common measures of lung function. Forced expiratory volume, or FEV1, represents the volume of air that can be forced out in one second after taking a deep breath. Peak expiratory flow rate represents how fast a person can exhale air.

Improvements occurred primarily in a sub
'"/>

Contact: Clare Halfhide
chalfhide@hotmail.com
Center for the Advancement of Health
25-Oct-2005


Page: 1 2 3

Related medicine news :

1. Little difference between human insulin and faster-acting drugs
2. Little change in suicidal thoughts, plans or attempts in US
3. Little evidence found for IVF as most effective infertility treatment
4. Little answers to worlds biggest problems
5. Majority of herb users dont follow evidence-based indications, researchers find
6. No evidence older women generate new eggs
7. Opportunistic chlamydia screening not underpinned by sound evidence
8. Drug safety recommendations lack scientific evidence
9. Study links attempted suicide with genetic evidence identified in previous suicide research
10. Fosrenol data show evidence of trends towards improved bone formation in CKD stage 5 patients
11. Mayo Clinic researchers find evidence for traumatic cause of carpal tunnel syndrome

Post Your Comments:
(Date:7/30/2015)... Marathon, FL (PRWEB) , ... July 30, 2015 ... ... streaming software, TikiLIVE, has worked to protect victims in San Diego, California’s Gaslamp ... cameras used by Gaslamp Quarter Plaza actively monitor the area for any ...
(Date:7/30/2015)... , ... July 30, 2015 , ... ... growing into one of the largest, family-owned low cost service and repair companies. ... commercial applications, as well as growing their company to meet the demands of ...
(Date:7/30/2015)... CA (PRWEB) , ... July ... ... recently released a video, “Beachside Nursing Center,” to announce its position as ... five-star ratings. Beachside's administrator and staff members support the CMS rating system, ...
(Date:7/30/2015)... , ... July 30, 2015 , ... Ross A. ... College of Medicine as Assistant Professor of Plastic Surgery. This is Dr. Clevens’ ... has worked closely with the university, developing a strong presence and a valuable mentoring ...
(Date:7/30/2015)... , ... July 30, 2015 , ... Using the latest ... and teach people more effective ways to prevent and manage major depression. , “Suicide ... fast enough, so people fall through the cracks and die needlessly everyday,” says Walker. ...
Breaking Medicine News(10 mins):Health News:Eyepartner Software Helps Victims in Gaslamp Quarter Plaza 2Health News:Eyepartner Software Helps Victims in Gaslamp Quarter Plaza 3Health News:Bill Howe Plumbing, Heating & Air Launches Online Application to Prospective Employees 2Health News:Bill Howe Plumbing, Heating & Air Launches Online Application to Prospective Employees 3Health News:Beachside Nursing Center Releases New Video 2Health News:Leading Melbourne Facial Plastic Surgeon Reappointed by UCF 2Health News:Leading Melbourne Facial Plastic Surgeon Reappointed by UCF 3Health News:Happiness Expert Develops Pioneering Online Tools for Sufferers of Major Depression, and Who may be Suicidal 2Health News:Happiness Expert Develops Pioneering Online Tools for Sufferers of Major Depression, and Who may be Suicidal 3
(Date:7/30/2015)... , July 30, 2015 Tianyin Pharmaceutical ... pharmaceutical company that specializes in the patented biopharmaceutical, modernized ... ingredients (API), provided updates regarding the notice it received ... (the "Exchange") indicating that the Company was below certain ... in Sections 134 and 1101 of the NYSE MKT ...
(Date:7/30/2015)... , July 30, 2015  Growth of the ... as they bring former prescription users to the OTC ... Kline forecasts robust Rx-to-OTC switch activity over the ... emerging along with many new brands entering the market ... over the next five years (even those with low ...
(Date:7/30/2015)... FAIRFIELD, N.J. , July 30, 2015 /PRNewswire/ ... Ferrer, completed the second Phase III clinical study ... development for impetigo.  Medimetriks owns the exclusive U.S. ... The global trial, conducted at 44 centers with ... and pediatric patients aged 2 months and older ...
Breaking Medicine Technology:TPI Provides Update Regarding Non-Compliance with NYSE MKT Continued Listing Requirements 2Rx-to-OTC Switches -- Game Changers for the U.S. OTC Drugs Market through 2019, Sees Kline 2Rx-to-OTC Switches -- Game Changers for the U.S. OTC Drugs Market through 2019, Sees Kline 3Medimetriks Pharmaceuticals, Inc. Announces Completion of the Second Successful Pivotal Phase III Study for Ozenoxacin 2Medimetriks Pharmaceuticals, Inc. Announces Completion of the Second Successful Pivotal Phase III Study for Ozenoxacin 3
Cached News: