HOME >> MEDICINE >> NEWS
Liver CRP production linked to atherosclerosis

Tsukuba, Japan --New research shows that levels of C-reactive protein (CRP), produced by the liver and not at the lesion site, correlate with the degree of atherosclerosis. The paper by Sun et al., "C-reactive protein in atherosclerotic lesions: its origin and pathophysiological significance," appears in the October issue of The American Journal of Pathology and is accompanied by a commentary.

C-reactive protein (CRP) is a hallmark of inflammation and tissue damage, as in arthritis or infection. It is also widely touted as a marker for cardiovascular disease, with doctors using patient CRP levels to improve risk assessment. However, whether CRP is merely a risk marker or is actually a contributing factor of cardiovascular disease has remained controversial.

To address these issues, Dr. Jianglin Fan's group examined the role of CRP in two rabbit models of atherosclerosis: high cholesterol diet or LDL receptor deficiency. Rabbits represent highly suitable models as they quickly form atherosclerotic plaques in response to high serum cholesterol, and rabbit CRP shares 70% homology with human CRP.

As expected, hypercholesterolemic rabbits developed atherosclerotic plaques. Upon further examination, serum CRP levels were found to positively correlate with plaque size. CRP was found in plaques of various stages, including early and advanced lesions, but it did not appear to associate with macrophages, as had been suggested. Similar results were seen in human aortic lesions.

To determine where CRP protein was being produced, CRP mRNA levels were measured by Northern blot and real-time RT-PCR. CRP mRNA was only detected in liver obtained from atherosclerotic rabbits but was undetectable in vascular cells or macrophages. Again, results were confirmed in human specimens: insignificant mRNA levels found in atherosclerotic aorta compared to high levels in liver. Finally, in vitro analysis revealed that hepatocytes, but not macrophage
'"/>

Contact: Audra Cox
acox@asip.org
301-634-7409
American Journal of Pathology
28-Sep-2005


Page: 1 2

Related medicine news :

1. Liver cancer patients with high serum levels of hepatitis B virus face poorer outcomes
2. Liver stiffness indicates portal hypertension
3. Liverpool launches 20 million project to develop medicines for children
4. Liver diagnosis breakthrough with Mayo Clinic MRI development
5. Liver-kidney transplant reduces organ rejection, boosts recovery
6. Liver transplants can be successful in HIV patients with Hepatitis B
7. Liverpool study highlights national crisis in pathology
8. Livers from non-heart beating donors would boost organ supply
9. Liver transplants may not be indicated for cystic fibrosis patients with bleeding complication
10. World leaders in cancer research to meet in Liverpool
11. Liverpool psychology helps bring peace to European football

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... Lori R. Somekh, founder of the ... national organization of elder law and special needs planning attorneys. “Membership in ElderCounsel helps ... provides a forum to network with elder law attorneys nationwide,” said Somekh. , ...
(Date:10/13/2017)... ... 2017 , ... Many families have long-term insurance that covers care for a ... waiver for care if the client has a cognitive impairment diagnosis. , “What ... is often waived, so the benefits from their insurance start immediately,” said Mechell Vieira, ...
(Date:10/13/2017)... York, NY (PRWEB) , ... October 13, 2017 , ... ... influential people in business to advocate for action towards gender equality at their inaugural ... views from around the globe, and reached a social audience of over 3 million. ...
(Date:10/13/2017)... ... 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House of ... popular and least understood books in the Holy Scriptures, Revelation. The Book of Revelation ... scholars for centuries. Many have tossed it off as mere rubbish, but Yisrayl Hawkins ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... Software Development, has been awarded a contract by the Center for Medicare and ... aims to accelerate the enterprise use of Agile methodologies in a consistent and ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... received FDA 510(k) clearance in May 2017 for its highly anticipated ... for endoscopy environments. An innovative secondary monitor solution, ZeroWire Mobile ... the improvement of patient outcomes, procedural efficiency, and the lowering of ... ... By ...
(Date:10/7/2017)... 6, 2017   Provista, a proven leader ... billion in purchasing power, today announced a new resource ... The Newsroom is the online home for case ... expert bios, news releases, slideshows and events. ... wealth of resources at their fingertips, viewers can also ...
(Date:10/4/2017)... , Oct. 4, 2017  South Korean-based healthcare product ... training aide "cprCUBE" on Kickstarter. The device will educate ... cardiac arrests with better efficiency compared to the dated ... real-time feedback on efficacy of the compression for a ... has a goal to raise $5,000. ...
Breaking Medicine Technology:
Cached News: