HOME >> MEDICINE >> NEWS
Low-carb diets' effects linked to rise in newly identified 'starvation hormone'

The benefits sometimes seen in those on a low-carbohydrate, high-fat diet may depend on increased levels of a newly identified "starvation hormone" produced by the liver, according to a report in the June issue of the journal Cell Metabolism, published by Cell Press. Two studies in the issue show that the hormone plays a critical role in the metabolic shift seen in animals after a period of fasting and in those fed an Atkins-like diet. That shift is characterized by an increased reliance on fat stores as an alternative source of fuel when glucose, the bodys primary energy source, plummets.

A team led by Eleftheria Maratos-Flier of Harvard University reports evidence that increased blood levels of liver-derived "fibroblast growth factor 21" (FGF21) are required for fasted mice and mice on a carbohydrate-restricted diet to switch gears and begin burning fat. Likewise, an accompanying study led by Steven Kliewer of the University of Texas Southwestern Medical Center found that FGF21 mobilizes fat in food-restricted animals and those with chronically elevated concentrations of the liver hormone. Kliewers team further showed that the hormone contributes to energy-conserving behavioral changes as animals ride out food shortages.

"Whats really exciting is that mice with excess FGF21even when they are fedlook like they are fasted," Kliewer said. "Its startling that you can give one hormone and flip the whole metabolic profile."

"We think these findings would increase the desirability of a drug that [might work through this mechanism] to increase fat oxidation in the liver," added Maratos-Flier, noting that the rise in obesity has contributed to a growing epidemic of nonalcoholic fatty liver disease. Although the physiology remained uncertain, pharmacological studies of mice and diabetic monkeys had previously shown promise for FGF21 therapy as a means to lower blood sugar and lipids and stave off weight gain.

Mammals survive period
'"/>

Contact: Erin Doonan
edoonan@cell.com
617-397-2802
Cell Press
5-Jun-2007


Page: 1 2 3

Related medicine news :

1. Low-carbohydrate diets appear effective, but may raise cholesterol levels
2. Low-carb diet better than low-fat diet at improving metabolic syndrome
3. Researchers find deadly prescription drug effects 6 years before FDA
4. New long-term data analyses for Bifeprunox show favorable effects vs. placebo
5. Chemical maps hint at drugs effects on schizophrenia
6. Agent protects cells from lethal effects of radiation even if given after exposure
7. OCT1 required for therapeutic effects of diabetes drug Metformin
8. Online book helps children understand the effects of stroke
9. Mechanism of hallucinogens effects discovered
10. Psychological effects of heart surgery examined
11. New report highlights aromatase inhibitor side effects

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/19/2019)... ... 19, 2019 , ... The California Dental Association is pleased ... refinancing as a new member benefit. , Student loan debt is one ... for all indebted graduates in the class of 2018 for public and private ...
(Date:2/19/2019)... , ... February 19, 2019 , ... ... dedicated to serving the entire family with modern, state-of-the-art dental treatments in a ... award-winning cosmetic dentist. While Dr. Roberts is known for providing advanced services in ...
(Date:2/19/2019)... ... 19, 2019 , ... NCPDP announced today that Dave deBronkart, ... will deliver the luncheon keynote on Tuesday, May 7, at its 2019 ... empowering partnerships between patients and their medical providers to NCPDP’s Annual Conference, May ...
(Date:2/19/2019)... ... February 19, 2019 , ... According to a recent study by ... previous work and daily routines; and only 26% of widows return to their pre-loss ... of a spouse is one of the most tragic events that one can face. ...
(Date:2/19/2019)... ... February 18, 2019 , ... AdventHealth Connerton is the first ... Sanitizing Stations to maximize infection control for patients and their families. The patented, ... and C. difficile, which can be transmitted from the bottoms of shoes to ...
Breaking Medicine News(10 mins):
(Date:2/19/2019)... ... February 19, 2019 , ... Periodontist, Dr. Arta ... utilizes modern dental lasers. The Laser Assisted New Attachment Procedure (LANAP) uses the ... the leading cause of gum disease. Dr. Farahmand is certified and trained to ...
(Date:2/19/2019)... ... February 19, 2019 , ... As many ... Dyslexia Association estimates that there are 1 billion people with dyslexia worldwide. In ... Education and founder of CMRubinWorld, Fredrik Wetterhall, the co-founder of Lexplore, discusses the ...
(Date:2/19/2019)... ... 2019 , ... Tap water issues in the greater Miami area? , “Nova ... looking forward to seeing the same great success in our new franchised Territory in ... Novak, President of Nova Filtration. , The drinking water in Miami primarily comes from ...
Breaking Medicine Technology:
Cached News: