HOME >> MEDICINE >> NEWS
Lowering blood pressure more important than drug class in preventing kidney disease

The first-line drug choices to treat high blood pressure in patients with kidney disease may not be the best option, according to an article in this week's issue of The Lancet.

National and international guidelines endorse the use of two classes of drugs--angiotensin-converting-enzyme (ACE) inhibitors and angiotensin-II receptor blockers (ARB)--as the first-line blood pressure-lowering therapy in patients with kidney disease. Doctors have assumed that these drugs have specific effects to protect the kidney beyond those resulting from their ability to lower blood pressure.

Raymond MacAllister and colleagues (Centre for Clinical Pharmacology, University College, London) investigated to what extent this consensus is supported by the available evidence. They undertook a review and meta-analysis of 127 randomised controlled trials investigating the effect of different classes of blood pressure-lowering drugs on the progression of kidney disease. The researchers found that ACE inhibitors and ARBs were no better than other blood pressure-lowering drugs in preventing diabetic kidney disease, and it was unclear if they were more effective in non-diabetic kidney disease.

The authors state "There seems to be little justification for ACE inhibitors or ARBs to be first-line choices for renoprotection in diabetes on the basis of efficacy, and residual uncertainty still exists about the inherent value of these drugs in other renal disorders. In view of the present analysis, treatment decisions for hypertension in renal disease should be based on the blood-pressure-lowering effect, comparative tolerability, and cost of antihypertensive treatment."


'"/>

Contact: Joe Santangelo
j.santangelo@elsevier.com
212-633-3810
Lancet
8-Dec-2005


Page: 1

Related medicine news :

1. Lowering body temperature could aid standard stroke treatment
2. Lowering of blood pressure achieved through use of hashish-like drug
3. Lowering blood pressure doesnt prevent cognitive impairment, dementia
4. Lowering resistance to insulin may delay or prevent onset of type 2 diabetes
5. Even low levels of weekly exercise drive down blood pressure
6. Chemotherapy with bevacizumab increases risk of blood clots in arteries
7. High blood pressure problems largely misunderstood by sufferers
8. Trial stops after stroke and mortality significantly reduced by blood
9. Program announced to improve care in developing areas for patients with blood disorders
10. New nutritional research: College students face obesity, high blood pressure, metabolic syndrome
11. Study shows Diachrome improves blood sugar control in people with type 2 diabetes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/21/2020)... ... February 21, 2020 , ... The American ... Cancer Leaders’ Summit in Boston, MA, in October 2021. The prestigious, invitation-only event—organized ... including prime ministers, ministers of health, city and industry leaders, senior executives and ...
(Date:2/20/2020)... ... February 20, 2020 , ... Millennial women are flocking to cosmetic surgeons ... Milford, Penn requesting treatments to achieve “ Rich Girl Face .” In fact, Glamour ... is slowing down into 2020. It’s a look inspired by the signature bee-stung lips, ...
(Date:2/19/2020)... ... 2020 , ... The American College of Lifestyle Medicine (ACLM) ... Residency Curriculum (LMRC). The curriculum is the first comprehensive, applicable and flexible Lifestyle ... resident involvement, the curriculum has included residents in every aspect of its creation ...
(Date:2/19/2020)... ... February 19, 2020 , ... ... consistency of healthcare delivery, announced that it will participate in the HIMSS20 ... Florida. BPM+ Health will engage healthcare professionals and other stakeholders at HIMSS20 – ...
(Date:2/16/2020)... ... February 16, 2020 , ... ... it is partnering with AABB and The Joint Commission to provide a complimentary ... PBM teams (directors, managers, coordinators and transfusion safety officers) within U.S. hospitals. ...
Breaking Medicine News(10 mins):
(Date:2/23/2020)... ... 23, 2020 , ... World-renowned actor Laurence Fishburne ( https://en.wikipedia.org/wiki/Laurence_Fishburne ... features a wide array of subjects impacting people all around the world today. ... discuss the importance of preventative dentistry and proper oral hygiene., Preventative dentistry is ...
(Date:2/21/2020)... (PRWEB) , ... February 21, 2020 , ... The business ... and staff, keeping up with industry trends and ensuring patients digital and physical safety, ... to the wayside. , That’s why MaintenX International’s is excited to provide their ...
(Date:2/20/2020)... ... February 20, 2020 , ... Enquire, a leading provider of cloud ... is proud to announce G5 as a Silver Sponsor of Enquire Summit 2020, scheduled ... to return to Enquire Summit as a Silver Sponsor. This event truly empowers sales ...
Breaking Medicine Technology:
Cached News: