HOME >> MEDICINE >> NEWS
Lowering blood pressure more important than drug class in preventing kidney disease

The first-line drug choices to treat high blood pressure in patients with kidney disease may not be the best option, according to an article in this week's issue of The Lancet.

National and international guidelines endorse the use of two classes of drugs--angiotensin-converting-enzyme (ACE) inhibitors and angiotensin-II receptor blockers (ARB)--as the first-line blood pressure-lowering therapy in patients with kidney disease. Doctors have assumed that these drugs have specific effects to protect the kidney beyond those resulting from their ability to lower blood pressure.

Raymond MacAllister and colleagues (Centre for Clinical Pharmacology, University College, London) investigated to what extent this consensus is supported by the available evidence. They undertook a review and meta-analysis of 127 randomised controlled trials investigating the effect of different classes of blood pressure-lowering drugs on the progression of kidney disease. The researchers found that ACE inhibitors and ARBs were no better than other blood pressure-lowering drugs in preventing diabetic kidney disease, and it was unclear if they were more effective in non-diabetic kidney disease.

The authors state "There seems to be little justification for ACE inhibitors or ARBs to be first-line choices for renoprotection in diabetes on the basis of efficacy, and residual uncertainty still exists about the inherent value of these drugs in other renal disorders. In view of the present analysis, treatment decisions for hypertension in renal disease should be based on the blood-pressure-lowering effect, comparative tolerability, and cost of antihypertensive treatment."


'"/>

Contact: Joe Santangelo
j.santangelo@elsevier.com
212-633-3810
Lancet
8-Dec-2005


Page: 1

Related medicine news :

1. Lowering body temperature could aid standard stroke treatment
2. Lowering of blood pressure achieved through use of hashish-like drug
3. Lowering blood pressure doesnt prevent cognitive impairment, dementia
4. Lowering resistance to insulin may delay or prevent onset of type 2 diabetes
5. Even low levels of weekly exercise drive down blood pressure
6. Chemotherapy with bevacizumab increases risk of blood clots in arteries
7. High blood pressure problems largely misunderstood by sufferers
8. Trial stops after stroke and mortality significantly reduced by blood
9. Program announced to improve care in developing areas for patients with blood disorders
10. New nutritional research: College students face obesity, high blood pressure, metabolic syndrome
11. Study shows Diachrome improves blood sugar control in people with type 2 diabetes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/17/2019)... ... September 17, 2019 , ... National University has ... American Heart Association (AHA)-San Diego Chapter to raise awareness of heart health. Meb ... Saturday, September 21 in Balboa Park alongside National University System Chancellor and AHA ...
(Date:9/17/2019)... ... September 17, 2019 , ... ... contributing to the long-term health of canines – specifically golden retrievers - through ... Retrievers will die from cancer – one out of five retrievers in the ...
(Date:9/17/2019)... (PRWEB) , ... September 17, 2019 , ... ... to join the largest accountable care organization (ACO) in the country, the company ... this groundbreaking collaboration to improve care quality and increase cost efficiency. This opportunity ...
(Date:9/17/2019)... ... September 17, 2019 , ... Dr. Perry Patel, ... been certified by the American Academy of Facial Esthetics (AAFE) to administer Botox ... range of orofacial conditions such as tooth clenching and grinding, tongue tension, temporomandibular ...
(Date:9/17/2019)... ... September 17, 2019 , ... The ... announce the release of the third edition of The Gift of Participation. Written ... patients, caregivers and families to navigate the clinical research process. The new edition ...
Breaking Medicine News(10 mins):
(Date:9/17/2019)... ... September 17, 2019 , ... Drs. ... and Medford, NJ, now welcome patients from Cherry Hill, NJ for tooth extractions, ... teeth whenever possible. When tooth removal is necessary, they use advanced equipment and ...
(Date:9/17/2019)... ... September 17, 2019 , ... Embr Labs , the ... Series B funding led by DigiTx Partners, with participation from Safar Partners, ... use the investment to grow the company’s footprint in wellness and digital therapeutics, accelerate ...
(Date:9/14/2019)... ... September 13, 2019 , ... ... for employers, became the first commercial teledentistry practice in the United States. Now, ... other hub entrepreneurs, company leaders, innovators and industry experts next week at CIC ...
Breaking Medicine Technology:
Cached News: