HOME >> MEDICINE >> NEWS
Lowering body temperature could aid standard stroke treatment

CINCINNATIUniversity of Cincinnati (UC) scientists have developed a model that could help physicians combine current clot-busting medication with below-normal body temperatures (hypothermia) to improve the treatment of ischemic stroke patients.

Thought to be first report of the temperature dependence of the standard, FDA-approved stroke medicationan enzyme called tissue plasminogen activator (tPA)in human clots and plasma, the findings could prove useful in predicting the efficacy of tPA over a wide range of temperatures, the UC researchers say.

The work is reported in the May 2007 issue of Physics in Medicine and Biology.

It is already known that lowering a patient's temperature reduces the metabolic activity of ischemic (clot-causing) cells, which in turn reduces cell damage and death.

But, says George Shaw, MD, PhD, who led the UC team, while several research centers are studying the use of hypothermia treatment for both stroke and heart attacks, little is known about how effective tPA is in the lab or the human body at lower temperatures.

Using the Celsius (centigrade) scale, normal human body temperature is 37 degrees. Shaw and his team tested tPA, which like most enzymes is very temperature dependent, to see how well it broke up clots at temperatures ranging from 30 to 39.5 degrees Celsius.

The researchers used blood samples from ten healthy donors to form 226 small clots, exposed the clots to fresh-frozen human plasma and tPA at various temperatures, then measured how much mass the clots lost.

Shaw says that while he and his colleagues fully expected to find that tPA is less effective at lower temperatures, their study enabled them to develop a model to explain the mechanism of how tPA gets into the clot and subsequently breaks it up.

"Around 33 Celsius is what most folks would consider the target temperature in cooling for therapeutic hypothermia," Shaw explains, "although
'"/>

Contact: Jamie Davis
jamie.davis@uc.edu
513-558-4625
University of Cincinnati
17-May-2007


Page: 1 2

Related medicine news :

1. Lowering of blood pressure achieved through use of hashish-like drug
2. Lowering blood pressure doesnt prevent cognitive impairment, dementia
3. Lowering blood pressure more important than drug class in preventing kidney disease
4. Lowering resistance to insulin may delay or prevent onset of type 2 diabetes
5. Forget basal body temperature -- check out her clothes
6. FDA approves room temperature storage of ZLB Behrings Helixate FS
7. Seat belt injuries could signal more serious trauma in children
8. Using MRI for diagnosis could help prevent breast cancer progression
9. Metabolic study in mice could lead to good cholesterol boosters
10. Miniature implanted devices could treat epilepsy, glaucoma
11. Health reform bills could improve quality and efficiency, but fall short of national plan

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/30/2021)... , ... March 29, 2021 , ... ... the 21st Century , A Virtual Workshop Presented by WCG FDAnews and Cerulean ... 4:30 pm EDT, https://wcg.swoogo.com/modern-sop-and-quality-systems , Are one’s SOPs written for the ...
(Date:3/30/2021)... ... March 29, 2021 , ... According to data released ... reproductive age (13-44) in need of publicly funded contraception live in counties impacted by ... Colorado’s 64 counties have lost some of their Title X resources. , The ...
(Date:3/30/2021)... ... March 29, 2021 , ... Health Literacy Innovations (HLI), a ... confusion due to low health literacy today announces a new partnership with the ... work with ACAP’s member Safety Net Health Plans, those that provide comprehensive health ...
(Date:3/30/2021)... ... ... Dr. Colin Campbell is proud to announce the 1 year anniversary in their new state ... internal medicine and is a primary care specialist who has been practicing for 23 years. ... keep South Jersey healthy one patient at a time. , “Over the past year, Dr. ...
(Date:3/30/2021)... ... March 30, 2021 , ... The COVID-19 ... and survivors; their families; and their caregivers. Crossroads4Hope is addressing the needs of ... emotional support system, MyGo2Support, which meets needs of people impacted by cancer, no ...
Breaking Medicine News(10 mins):
(Date:3/30/2021)... ... March 29, 2021 , ... The University of Texas Health Science Center ... San Antonio Multispecialty and Research Hospital, a destination center for research and treatment of ... In a nod to the COVID-19 pandemic, the ceremony was held virtually. , William ...
(Date:3/30/2021)... ... March 29, 2021 , ... Iora Health ... primary care, has partnered with Devoted Health , one of the fastest-growing ... across Maricopa County and provides seniors with the highest-quality care and experience possible, ...
(Date:3/30/2021)... CITY (PRWEB) , ... March 29, 2021 , ... ... has joined the Vaccine Credential Initiative (VCI), a group bringing together leading health ... record of vaccination status, based on open, interoperable standards. By joining the VCI ...
Breaking Medicine Technology:
Cached News: