Lowering resistance to insulin may delay or prevent onset of type 2 diabetes

SAN DIEGO (June 11, 2005)-Type 2 diabetes may be significantly delayed or prevented through medication that takes the load off of the body's delicate insulin-producing cells, according to a study released today by researchers at the Keck School of Medicine of the University of Southern California.

They presented their findings at the American Diabetes Association's 65th Scientific Sessions.

The Pioglitazone in Prevention of Diabetes (PIPOD) study tested whether the drug pioglitazone could protect women who had had gestational diabetes-a temporary form of diabetes during pregnancy-from developing type 2 diabetes later, explains study presenter Thomas A. Buchanan, M.D., professor of medicine, obstetrics and gynecology and physiology and biophysics at the Keck School.

Although most women with gestational diabetes do not remain diabetic right after delivery, they do commonly remain resistant to their insulin, and 30 to 50 percent of them develop type 2 diabetes within a few years after pregnancy. Because of that, studying women with gestational diabetes is useful for researchers seeking to understand diabetes and develop ways to prevent it.

In the study, researchers provided pioglitazone for three years to 89 women who had had gestational diabetes and who had already participated in their diabetes prevention study called TRIPOD, which used the drug troglitazone. Troglitazone reduced diabetes risk from 12 percent a year to only 5 percent a year. However, troglitazone was removed from use in 2000 because it caused rare but severe liver damage in those with type 2 diabetes.

For PIPOD, researchers used pioglitazone (also called Actos), which works similarly to troglitazone but is safe for the liver, to see if the diabetes rate would remain low. It did, less than 5 percent each year. Moreover, among those women who remained diabetes-free, beta-cell function did not change while the women were taking pioglitazone. Beta c

Contact: Richard Stone
University of Southern California

Page: 1 2 3

Related medicine news :

1. Lowering body temperature could aid standard stroke treatment
2. Lowering of blood pressure achieved through use of hashish-like drug
3. Lowering blood pressure doesnt prevent cognitive impairment, dementia
4. Lowering blood pressure more important than drug class in preventing kidney disease
5. New cause of tamoxifen resistance in breast cancer cells discovered at Lombardi
6. LAP-BAND System surgery improves insulin resistance
7. New mechanism identified for resistance to targeted lung cancer drugs
8. New project to analyze why Polycystic Ovary Syndrome and insulin resistance are so closely linked
9. Study finds antibiotic resistance in poultry even when antibiotics were not used
10. Drug resistance in an influenza pandemic
11. Rapid flu tests may reduce threat of antibiotic resistance

Post Your Comments:

(Date:10/15/2019)... ... 15, 2019 , ... Nashville Fertility Center (NFC) is proud to announce that ... the practice. In addition to treating general infertility, Dr. Van Heertum offers expertise in ... looks forward to Dr. Van Heertum joining the practice and believes she is the ...
(Date:10/10/2019)... FRANKLIN, Tenn. (PRWEB) , ... October 10, 2019 ... ... provider of management consulting and information technology (IT) services for the healthcare industry, ... advance the Public Hospitals Authority (PHA) of the Commonwealth of The Bahamas towards ...
(Date:10/8/2019)... (PRWEB) , ... October 08, 2019 , ... SoCal Adolescent ... are happy to announce the expansion of our services to better serve the families ... opportunity over this last year to see the extraordinary impact this pre-intervention program has ...
(Date:10/8/2019)... ... October 08, 2019 , ... As ... samples, Meiqing Shi, associate professor with the University of Maryland Department of Veterinary ... published in Nature Communications, Shi and his lab have discovered a new pathway ...
(Date:10/8/2019)... ... October 08, 2019 , ... Smile Brands Inc. has ... compensation monitoring site, Comparably. Smile Brands, a leading dental support organization with nearly 440 ... mission to deliver Smiles for Everyone®. The Happiness Award is the latest in a ...
Breaking Medicine News(10 mins):
(Date:10/19/2019)... ... ... Hospital M&A activity held steady with 21 transactions in both the second and ... quarter was down 20% compared with the same period in 2018, when 25 deals ... $5.0 billion, a 291% increase. Year over year, Q3:19 spending was down 41% versus ...
(Date:10/17/2019)... , ... October 17, 2019 , ... The findings of ... illness in the individuals studied could be caused by toxic chemicals rather than the ... Pulmonary Illness Associated With E-Cigarette Use (Vaping): A Report of Eight Cases ,” by ...
(Date:10/15/2019)... ... October 15, 2019 , ... Twiggy Bean, Ph.D., wanted to educate ... embittered divorce battles make better decisions and become truly child focused. This objective prompted ... be resilient, and STOP the cycle! Don’t be a divorce bully!” (published by Balboa ...
Breaking Medicine Technology:
Cached News: