HOME >> MEDICINE >> NEWS
Lymph nodes harbor information on whether breast cancer will recur

Breast cancer often spreads through the lymph nodes in the arm pits (so-called axillary lymph nodes), and whether these lymph nodes are tumor-free or contain small metastases is an important factor in the decision of how aggressively to treat a patient. Peter Lee and colleagues (from Stanford University) now report in the open access journal PLoS Medicine that looking at the immune status of lymph nodes might teach us even more about a specific breast tumor. They found that the 'immune profile' (i.e. the number and composition of immune cells) of an axillary lymph node can independently predict the chances that the cancer will come back. This suggests that lymph node immune profiles can help to inform individualized treatment decisions.

The researchers examined 104 axillary lymph nodes from 77 patients. Five-year follow-up data were available for all patients, 33 of whom had disease recurrence within that time. They found that, regardless of whether the nodes contained tumor cells, the numbers of two different sets of immune cells, CD4 T cells and dendritic cells, were correlated with disease-free survival. Moreover, for this group of patients, the predictive power of the immune profiles was better than that of any other clinical parameters, including tumor size and extent or size of lymph node metastases.

All patients in this study had some lymph nodes that contained tumor cells, and the results suggest that for such patients, immune profile data from axillary nodes hold additional information on the probability of disease recurrence. An important open question is whether immune profile information from lymph nodes can predict risk of recurrence even in women whose cancers are caught at a very early stage where they have not yet spread to any lymph nodes.


'"/>

Contact: Paul Ocampo
press@plos.org
415-624-1224
Public Library of Science
5-Sep-2005


Page: 1

Related medicine news :

1. Lymph node evaluation linked to improved survival for colon cancer patients
2. Lymphoma survivor recognized for helping Denver cancer patients
3. Colon cancer survival linked to number of lymph nodes examined
4. Patients with suspicious axillary breast lymph nodes should undergo fine-needle aspiration
5. Angiogenesis factor may help tumors prepare the way for spread to lymph nodes
6. Researchers discover gut tissue to be a major reservoir harboring HIV
7. New study says two million Americans harbor drug-resistant superbug
8. Threats to hope -- Desperation affects reasoning about product information
9. Award winning book co-edited by Rutgers College of Nursing Dean updated with new information
10. ACP supports improved access to information on relative strengths and weaknesses
11. Women with breast cancer do not get potentially life-saving information, survey reveals

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/27/2016)... ... ... "FCPX editors can now reveal their media with growing colorful split screen ... - CEO of Pixel Film Studios. , ProSlice Color brings the split screens ... reveal the media of their split screens with growing colorful panels. , ProSlice Color ...
(Date:6/26/2016)... ... 27, 2016 , ... Quality metrics are proliferating in cancer care, and are ... the eye of the beholder, according to experts who offered insights and commentary in ... Managed Care. For the full issue, click here . , For the American ...
(Date:6/26/2016)... ... June 26, 2016 , ... Many ... been diagnosed with endometriosis. These women need a treatment plan to not only ... approach that can help for preservation of fertility and ultimately achieving a pregnancy. ...
(Date:6/25/2016)... Lewisville, TX (PRWEB) , ... June 25, 2016 , ... ... in the United States, named Dr. Sesan Ogunleye, as the Medical Director of its ... be the facility Medical Director of our new Mesquite location,” said Dr. James M. ...
(Date:6/24/2016)... Angeles, CA (PRWEB) , ... June 24, 2016 , ... ... surgery procedures that most people are unfamiliar with. The article goes on to state ... procedures, but also many of these less common operations such as calf and cheek ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... KNOXVILLE, Tenn. , June 24, 2016 /PRNewswire/ ... market providing less invasive and more durable cerebrospinal ... million in funding.  The Series-A funding is led ... the Lighthouse Fund, and other private investors.  Arkis, ... less-invasive neurosurgical instrumentation and the market release of ...
(Date:6/23/2016)... 2016 Research and Markets has ... by Type (Organic Chemical (Sugar, Petrochemical, Glycerin), Inorganic Chemical), ... Parenteral) - Global Forecast to 2021" report to ... The global pharmaceutical excipients market is projected to reach ... 6.1% in the forecast period 2016 to 2021. ...
(Date:6/23/2016)... 23, 2016 Capricor Therapeutics, ... a biotechnology company focused on the discovery, development ... patient enrollment in its ongoing randomized HOPE-Duchenne clinical ... 50% of its 24-patient target. Capricor expects the ... quarter of 2016, and to report top line ...
Breaking Medicine Technology:
Cached News: