HOME >> MEDICINE >> NEWS
Lymph nodes harbor information on whether breast cancer will recur

Breast cancer often spreads through the lymph nodes in the arm pits (so-called axillary lymph nodes), and whether these lymph nodes are tumor-free or contain small metastases is an important factor in the decision of how aggressively to treat a patient. Peter Lee and colleagues (from Stanford University) now report in the open access journal PLoS Medicine that looking at the immune status of lymph nodes might teach us even more about a specific breast tumor. They found that the 'immune profile' (i.e. the number and composition of immune cells) of an axillary lymph node can independently predict the chances that the cancer will come back. This suggests that lymph node immune profiles can help to inform individualized treatment decisions.

The researchers examined 104 axillary lymph nodes from 77 patients. Five-year follow-up data were available for all patients, 33 of whom had disease recurrence within that time. They found that, regardless of whether the nodes contained tumor cells, the numbers of two different sets of immune cells, CD4 T cells and dendritic cells, were correlated with disease-free survival. Moreover, for this group of patients, the predictive power of the immune profiles was better than that of any other clinical parameters, including tumor size and extent or size of lymph node metastases.

All patients in this study had some lymph nodes that contained tumor cells, and the results suggest that for such patients, immune profile data from axillary nodes hold additional information on the probability of disease recurrence. An important open question is whether immune profile information from lymph nodes can predict risk of recurrence even in women whose cancers are caught at a very early stage where they have not yet spread to any lymph nodes.


'"/>

Contact: Paul Ocampo
press@plos.org
415-624-1224
Public Library of Science
5-Sep-2005


Page: 1

Related medicine news :

1. Lymph node evaluation linked to improved survival for colon cancer patients
2. Lymphoma survivor recognized for helping Denver cancer patients
3. Colon cancer survival linked to number of lymph nodes examined
4. Patients with suspicious axillary breast lymph nodes should undergo fine-needle aspiration
5. Angiogenesis factor may help tumors prepare the way for spread to lymph nodes
6. Researchers discover gut tissue to be a major reservoir harboring HIV
7. New study says two million Americans harbor drug-resistant superbug
8. Threats to hope -- Desperation affects reasoning about product information
9. Award winning book co-edited by Rutgers College of Nursing Dean updated with new information
10. ACP supports improved access to information on relative strengths and weaknesses
11. Women with breast cancer do not get potentially life-saving information, survey reveals

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Lymph nodes harbor information whether breast cancer will recur

(Date:2/28/2015)... (PRWEB) February 28, 2015 Mew and ... announced that they now provide business consulting services in ... as corporate tax planning and succession planning. Company finances ... to experienced professionals. On top of this, complex Canadian ... handle corporate accounting. As a result, Mew and Company ...
(Date:2/28/2015)... 2015 Vancouver personal injury lawyers at Jiwa ... affected by time limits. They stated that in many cases, ... or even nullify it. Many a time, delays in making ... rights under BC law. As a result, experts at Jiwa ... should consult a personal injury lawyer in order to know ...
(Date:2/28/2015)... (PRWEB) February 28, 2015 Indosoft ... software suite for Asterisk, are pleased to announce the ... successful 5.7 and 5.8 versions of Q-Suite, this new ... as a number of new features to the leading ... 2015. , Q-Suite 5.9 will add features to enhance ...
(Date:2/28/2015)... A study out of the University of Oxford ... the treatment of a hereditary ocular condition that leads ... Dr. Robert MacLaren, professor of ophthalmology at the University ... on January 16, 2014 , the study treated six ... mostly affects men and leads to the degeneration of ...
(Date:2/28/2015)... (PRWEB) February 28, 2015 For those ... in person, the Mesothelioma Applied Research Foundation ... on Tuesday, March 3, starting at 9:30 AM. , ... no registration. The broadcast can be accessed through any ... http://www.curemeso.org/symposium . , The Symposium is a unique event ...
Breaking Medicine News(10 mins):Health News:Vancouver Corporate Tax Accountants Now Provide Business Consulting Services 2Health News:Jiwa Law Corporation Recently Announced That Time Delays May Weaken Personal Injury Claims 2Health News:Indosoft Proudly Announces Q-Suite 5.9 Call Center Software for Asterisk 2Health News:New Gene Therapy Procedure Could Hold Key to Preventing Blindness for Certain Patients 2Health News:Mesothelioma Cancer Research Foundation Broadcasting Symposium Live 2
(Date:2/27/2015)... 2015 Roughly three-quarters of pharmacists said ... an interchangeable biosimilar for its branded biologic counterpart ... name, according to a survey published in the ... of Managed Care & Specialty Pharmacy (JMCP). ... pharmacists would feel as confident if the products ...
(Date:2/27/2015)... 27, 2015 Pharmaceutical and biotech marketers are ... for the same indication. This can be a complex ... prevent one of their brands from gaining market share ... recent research by benchmarking firm, Best Practices, LLC, 75% ... rather than together as part of a franchise. Marketers ...
(Date:2/27/2015)... 27, 2015 The role of the Medical ... one thing hasn,t changed: face-to-face meetings are seen as ... Key Opinion Leaders. Yet at the same ... type of interaction, field medical teams within the pharmaceutical ... This is just one of the challenges addressed in ...
Breaking Medicine Technology:Survey Published in AMCP's JMCP Finds Pharmacists Are Most Confident Substituting Interchangeable Biosimilars for Brand Biologics When Products Share Nonproprietary Name 2New Report Details How to Expand a Pharmaceutical Product Portfolio without Cannibalizing an Established Brand 2Improving the Management of MSL Teams to Create Value across a Diverse Set of Customers 2
Cached News: