MIT nanoparticles may help detect, treat tumors

CAMBRIDGE, Mass.-A new technique devised by MIT engineers may one day help physicians detect cancerous tumors during early stages of growth.

The technique allows nanoparticles to group together inside cancerous tumors, creating masses with enough of a magnetic signal to be detectable by a magnetic resonance imaging (MRI) machine.

The work appears as the cover feature in the May issue of Angewandte Chemie International Edition, one of the world's leading chemistry journals.

The research, which is just moving into animal testing, involves injecting nanoparticles (billionths of a meter in size) made of iron oxide into the body, where they flow through the bloodstream and enter tumors.

Solid tumors must form new blood vessels to grow. But because this growth is so rapid in cancerous tumors, there are gaps in the endothelial cells that line the inside of the blood vessels. The nanoparticles can slip through these gaps to enter the tumors.

Once inside the tumor, the nanoparticles can be triggered to group together by a mechanism designed by the MIT engineers. Specifically, certain enzymes, or proteases, inside the tumors cause the nanoparticles to "self-assemble" or stick together. The resulting nanoparticle clumps are too big to get back out of the gaps. Further, the clumps have a stronger magnetic signal than do individual nanoparticles, allowing detection by MRI.

"We inject nanoparticles that will self-assemble when they are exposed to proteases inside of invasive tumors," said Sangeeta N. Bhatia, M.D., Ph.D., associate professor of the Harvard-MIT Division of Health Sciences & Technology (HST) and Electrical Engineering and Computer Science (EECS). "When they assemble they should get stuck inside the tumor and be more visible on an MRI. This might allow for noninvasive imaging of fast-growing cancer 'hot spots' in tumors." Bhatia also is affiliated with the MIT-Harvard Center of Cancer Nanotechnology Excellence.


Contact: Elizabeth Thomson
Massachusetts Institute of Technology

Page: 1 2

Related medicine news :

1. Targeted nanoparticles incorporating siRNA offer promise for cancer treatment
2. U-M researchers use nanoparticles to target brain cancer
3. Electric jolt triggers release of biomolecules, nanoparticles
4. Beyond the hype and the scare stories, how safe are nanoparticles?
5. Michigan State research sheds new light on health dangers of nanoparticles
6. Viral, gold nanoparticles can assemble themselves to potentially find and treat disease
7. Gold nanoparticles, radiation combo may slow Alzheimers
8. University of Georgia team investigates effects of nanoparticles on environment
9. Gold nanoparticles show potential for noninvasive cancer treatment
10. Researchers demonstrate use of gold nanoparticles for cancer detection
11. New study demonstrates combined techniques to detect, monitor Alzheimers disease

Post Your Comments:

(Date:9/9/2019)... (PRWEB) , ... September 09, 2019 , ... ... unanimously to adopt an organization-wide policy focusing on a diabetes-language movement (#LanguageMatters) to ... that is neutral and non-judgmental, free from stigma, respectful and inclusive, empowering, and ...
(Date:9/8/2019)... , ... September 08, 2019 , ... ... support with more than $200,000 contributed on Kickstarter (over 13-times its ... relaxation by naturally increasing blood circulation and reducing tension. , “We created GoRelax ...
(Date:9/8/2019)... (PRWEB) , ... September 06, 2019 , ... The Plantrician ... the 7th Annual Plant-based Nutrition Healthcare Conference, where close to 1000 medical ... use of evidence-based research pertaining to the use of whole food, plant-based nutrition in ...
(Date:9/4/2019)... , ... September 04, 2019 , ... ... Cycle Management services, proudly announces its achievement of securing the 4th position in ... specialty by Black Book™ in its recent survey that evaluated ambulatory electronic health ...
(Date:9/4/2019)... , ... September 04, 2019 , ... ... course scheduled for October 18-19th, 2019. The nation's leading hands-on regenerative training course ... hands-on participation. Currently, registration is $1000 off, and each attendee also receives a ...
Breaking Medicine News(10 mins):
(Date:9/11/2019)... (PRWEB) , ... September 11, 2019 , ... ... 10 causes of mortality in the US. However, patients may not receive the ... days to complete. Rapid molecular detection of these pathogens has shown improvement ...
(Date:9/11/2019)... ... 2019 , ... Abilene Christian University (ACU) is offering an alternative entry point ... BSN to DNP program pathway is meant to serve as a fast track for ... to a Doctor of Nursing Practice degree. , Traditionally, a student would need ...
(Date:9/11/2019)... ... 11, 2019 , ... About the Session, Medical conferences provided ... than ever through the rise of online social media platforms. The internet gives ... thoughts and ideas about that information within the public eye. , Derdowski proposes ...
Breaking Medicine Technology:
Cached News: