MRI contrast agent can detect heart attack in the making

CHICAGO, March 27 A new bright spot in heart disease research may soon allow physicians to peer directly into patients' blood vessels and find dangerous cholesterol-filled plaques before they rupture and cause a heart attack.

Scientists at New Yorks Mount Sinai Medical Center and the New York University School of Medicine, under the direction of Dr. Edward A. Fisher, M.D., Ph.D., and Dr. Zahi A. Fayad, M.D., Ph.D., have developed a synthetic molecule that delivers an imaging enhancer to cholesterol-filled cells embedded in the arterial walls. In animal tests, the enhancer improved cholesterol detection by 79 percent.

The new technique would allow physicians to diagnose unstable plaques before they rupture, and save lives by identifying the highest risk patients, says Fayad, director of the Mount Sinai cardiovascular imaging research laboratory.

When used with magnetic resonance imaging (MRI), the plaques appear bright, allowing physicians to measure inflammation in artery walls and assess overall cholesterol buildup. The technique also could be used to follow a patients response to therapy.

Details of the new technique were described today at the 233rd national meeting of the American Chemical Society, the worlds largest scientific society, by David Cormode, Ph.D., a postdoctoral researcher at the Mount Sinai School of Medicine, who worked with the group.

Efforts to view cholesterol buildup in arteries have long been hindered by the inability to deliver imaging agents directly into plaques. Even in diseased arteries, the lining is often intact, preventing particles from entering the plaque.

But high-density lipoprotein, also known as HDL or good cholesterol, moves freely through this barrier to carry cholesterol out of plaques to the liver, where it is eliminated from the body.

Using an artificially synthesized peptide, the scientists devised a way to construct HDL-like molecules that could t


Page: 1 2

Related medicine news :

1. Fluorescence diffuse optical tomography provides high contrast, 3-D look at breast cancer
2. High-resolution imaging with contrast agent shows promise in osteoarthritis research
3. Using contrast enhanced sonography improves diagnosis of liver and spleen injuries
4. Reducing contrast material injection in elderly patients can lower cost of exam and risks
5. New contrast agents may be on horizon for better medical imaging
6. Combined contrast enhanced MRI shows promise
7. MDCT shows potential for detecting bladder cancer without surgery or contrast
8. Gadonanotubes greatly outperform existing MRI contrast agents
9. Shark cartilage shows no benefit as a therapeutic agent for lung cancer
10. Targeted, oral agent Enzastaurin shows favorable results
11. Studies suggest investigational agent reduces disease activity in MS

Post Your Comments:

(Date:10/13/2017)... ... October 13, 2017 , ... Lori R. Somekh, founder of the ... national organization of elder law and special needs planning attorneys. “Membership in ElderCounsel helps ... provides a forum to network with elder law attorneys nationwide,” said Somekh. , ...
(Date:10/13/2017)... ... 2017 , ... Many families have long-term insurance that covers care for a ... waiver for care if the client has a cognitive impairment diagnosis. , “What ... is often waived, so the benefits from their insurance start immediately,” said Mechell Vieira, ...
(Date:10/13/2017)... York, NY (PRWEB) , ... October 13, 2017 , ... ... influential people in business to advocate for action towards gender equality at their inaugural ... views from around the globe, and reached a social audience of over 3 million. ...
(Date:10/13/2017)... ... 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House of ... popular and least understood books in the Holy Scriptures, Revelation. The Book of Revelation ... scholars for centuries. Many have tossed it off as mere rubbish, but Yisrayl Hawkins ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... Software Development, has been awarded a contract by the Center for Medicare and ... aims to accelerate the enterprise use of Agile methodologies in a consistent and ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... received FDA 510(k) clearance in May 2017 for its highly anticipated ... for endoscopy environments. An innovative secondary monitor solution, ZeroWire Mobile ... the improvement of patient outcomes, procedural efficiency, and the lowering of ... ... By ...
(Date:10/7/2017)... 6, 2017   Provista, a proven leader ... billion in purchasing power, today announced a new resource ... The Newsroom is the online home for case ... expert bios, news releases, slideshows and events. ... wealth of resources at their fingertips, viewers can also ...
(Date:10/4/2017)... , Oct. 4, 2017  South Korean-based healthcare product ... training aide "cprCUBE" on Kickstarter. The device will educate ... cardiac arrests with better efficiency compared to the dated ... real-time feedback on efficacy of the compression for a ... has a goal to raise $5,000. ...
Breaking Medicine Technology:
Cached News: