MRI detects most missed opposite breast cancers in women

PROVIDENCE, R.I. [Brown University] -- Up to 10 percent of women newly diagnosed with cancer in one breast develop cancer in the opposite breast. Results of a major clinical trial show that magnetic resonance imaging (MRI) scans are highly effective tools for quickly identifying these opposite breast cancers, detecting diseased tissue that other screening methods missed.

In the new trial, conducted by the American College of Radiology Imaging Network (ACRIN) and funded by the National Cancer Institute, researchers wanted to determine whether MRI could improve doctors ability to identify these opposite breast cancers right at the initial diagnosis boosting the chances for swift and successful treatment.

The results, published in the New England Journal of Medicine, show that for women already diagnosed with cancer in one breast, MRI scans detected more than 90 percent of cancers in the opposite, or contralateral, breast.

"The study establishes MRI as a key component of the diagnostic workup for women with breast cancer," said Constantine Gatsonis, lead statistician for the trial and director of the Center for Statistical Sciences at Brown University. "If my wife were diagnosed with breast cancer, Id be sure that she got an MRI of the opposite breast."

Gatsonis, a Brown professor of biostatistics, oversaw design of the MRI trial and led analysis of its results. He offered a caveat: The study showed that MRI is an effective addition to but not a replacement for clinical breast exams and mammography.

"This study wasnt designed to determine whether mammography or MRI is a better screening test for breast cancer in women at average risk," Gatsonis said. "It was designed only to see if MRI improved detection of cancers in the other breasts of women already diagnosed with unilateral breast cancer."

In the trial, 1,007 women were recruited from 25 clinical sites in the United States, Canada and Germany. A tota

Contact: Wendy Lawton
Brown University

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