In "The search for antecedent biomarkers of Alzheimer's disease," Anne M. Fagan, Cynthia A. Csernansky, John C. Morris, and David M. Holtzman (Washington University in St. Louis), discuss some of the challenges surrounding the development of biomarkers for "preclinical AD."
Thomas J. Montine, Joseph F. Quinn, Kathleen S. Montine, Jeffrey A. Kaye, and John C.S. Breitner (University of Washington and Oregon Health & Science University), in "Quantitative in vivo biomarkers of oxidative damage and their application to the diagnosis and management of Alzheimer's disease," discuss how the monitoring of F2-isoprostanes in cerebro-spinal fluid (CSF) is showing promise as a diagnostic tool for monitoring potential anti-oxidant therapies for AD.
Inflammatory processes have also been implicated in AD. Robert E. Mrak and W. Sue T. Griffin (University of Arkansas) review proinflammatory cytokines as potential markers for AD, pointing out in "Inflammatory biomarkers in Alzheimer's disease" the difficulties in the use of such markers due to complicating genetic factors.
Finally, Jing Zhang, David R. Goodlett, and Thomas J. Montine (University of Washington) discuss recent advances in genomics, proteomics, and metabolomics. In "Proteomic Biomarker Discovery in Cerebrospinal Fluid for Neurodegenerative Diseases," the prospect for clinical diagnosis via unique protein markers is reviewed, as well as the practical limitations of proteomic analysis of human CSF.
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Contact: George Perry
george.perry@case.edu
216-368-2488
Case Western Reserve University
7-Mar-2006