HOME >> MEDICINE >> NEWS
Major discovery raises prospect of better patient care by improving platelet life span

The research team led by Drs Benjamin Kile and David Huang has discovered that platelet life span is controlled by two key molecules. The discovery raises the prospect of developing a new drug to prolong the life span of platelets stored in blood banks, effectively increasing the availability of this life-saving blood product.

An undesirable side effect of cancer chemotherapy is extensive bruising and potentially life-threatening bleeding. This is caused by the unintended depletion of platelets, tiny circulating blood cells that are essential for blood clotting and wound healing. Consequently, the well being of some patients depends upon platelet transfusions, particularly during the vulnerable periods that follow anti-cancer treatment. The significant demand for high quality platelets, coupled with their short shelf life of only five days, presents major logistical challenges in clinical practice.

The scientific team has found that two specialised molecules act in opposition to each other to control platelet life span by regulating the process known as "apoptosis." This term refers to the normal and healthy self destruction of old, damaged and surplus cells. One protein (known as Bcl-xL) acts to preserve the life of the platelet, while the other protein (Bak) prepares the cell to self-destruct after its usual life span within the body - about a week.

WEHI's Dr David Huang said, "Apoptosis is an essential process, common in other cells, but the central role it plays in controlling the life span of the highly specialised platelet has not been previously appreciated. With this new knowledge, we are in a much stronger position to devise better therapies for the management of platelet-related diseases."

Dr Kile added, "For fifty years doctors have speculated about what controls platelet life span. We now know the identity of the precise molecular switch responsible. The team is now actively pursuing a drug development program
'"/>

Contact: Brad Allan
allan@wehi.edu.au
61-393-452-345
Research Australia
22-Mar-2007


Page: 1 2

Related medicine news :

1. Chinese space agency joins the International Charter Space and Major Disasters
2. Major employers, physicians, stakeholders unite to revolutionize Americas healthcare system
3. Majority of herb users dont follow evidence-based indications, researchers find
4. Majority of state Medicaid programs have or plan to have pay-for-performance programs
5. Major visual disorders in people over 40 may be costing the US economy billions
6. Major cancer study aims to identify protein markers for early-stage disease
7. Majority of health care opinion leaders say Medicare Part D helps beneficiaries, changes are needed
8. Major grant to IU School of Medicine will expand HIV/AIDS programs in Kenya
9. Major WHO study concludes calcium supplements can reduce complications during pregnancy
10. Major biomarker candidates for Alzheimers disease explored
11. Major ovarian cancer clinical study announced at Yale using combination drug therapy

Post Your Comments:
(Date:11/28/2014)... Brosix is always making changes to its infrastructure architecture ... efficient, effective, and secure experience. Most recently, the company ... ability to setup local servers for each country or ... around the globe. , 2. The ability to setup ... require millions of users in one network. , 3. ...
(Date:11/28/2014)... Dr. Diane Walder, one of the South ... Dr. Bridgit Nolan to her practice as a cosmetic ... her dermatology residency at the University of Miami Miller ... Nolan to join her practice because of her ... only does Dr. Nolan strive to provide the utmost ...
(Date:11/28/2014)... (PRWEB) November 28, 2014 Mirena ... move forward in New Jersey’s Bergen County Superior ... consolidated litigation established there is quickly approaching 1,300, ... on November 18th shows 1,293 lawsuits now pending ... lawsuits that allege complications resulting from spontaneous migration ...
(Date:11/28/2014)... 28, 2014 Miami's Plastic Surgery of ... Practice founder Dr. Jeffrey Epstein is excited ... a groundbreaking WordPress platform, the site is uniquely designed ... Currently, up to 75% of all prospective rhinoplasty patients ... people are logging on with smartphones, tablets, and laptops, ...
(Date:11/28/2014)... 28, 2014 Secura Consultants, based ... insurance marketing organizations in the country focused on ... protection marketplace. Secura Consultants is proud to offer ... Financial Group, a leading global financial company. , ... With the ownership interest comes the need for ...
Breaking Medicine News(10 mins):Health News:Brosix Infrastructure Architecture Changes to Benefit Users 2Health News:Dr. Diane Walder Welcomes New Cosmetic Dermatologist to Practice 2Health News:Nearly 1,300 Mirena Lawsuits Now Filed in Consolidated New Jersey Litigation, Bernstein Liebhard LLP Reports 2Health News:Nearly 1,300 Mirena Lawsuits Now Filed in Consolidated New Jersey Litigation, Bernstein Liebhard LLP Reports 3Health News:Top Rhinoplasty Surgeon Launches Innovative Website 2Health News:Secura Consultants Offers Complimentary Buy-Sell Agreement Reviews 2
(Date:11/28/2014)... endedChange %  30 September 201430 September 2013Turnover 546,011 , 534,641 ... 384,242 , 339,113 , 13.3 Hospital ... , 49.5 Medical Insurance Administration Service Income , ... and Accessories Sales , 94,580 , 142,683 ... , 9,219 , (68.4) Impairment Loss on Fixed ...
(Date:11/26/2014)... Nov. 26, 2014  Thoratec Corporation (NASDAQ: ... support therapies to save, support and restore failing hearts, ... investor conferences. On Tuesday, December 2, the ... Piper Jaffray Healthcare Conference.  D. Keith Grossman , ... on the company beginning at 11:30 a.m., Eastern Standard ...
(Date:11/26/2014)... , Nov. 26, 2014  Cohen, Placitella ... behalf of investors who purchased Nymox Pharmaceutical Corporation ... during the period from January 31, 2011 through ... whether Nymox and certain of its officers and ... in violation of Sections 10(b) and 20(a) of ...
Breaking Medicine Technology:Golden Meditech Announces 2014 / 2015 Interim Results 2Golden Meditech Announces 2014 / 2015 Interim Results 3Golden Meditech Announces 2014 / 2015 Interim Results 4Golden Meditech Announces 2014 / 2015 Interim Results 5Golden Meditech Announces 2014 / 2015 Interim Results 6Golden Meditech Announces 2014 / 2015 Interim Results 7Golden Meditech Announces 2014 / 2015 Interim Results 8Thoratec Announces Presentations At Investor Conferences For December 2014 2Cohen, Placitella & Roth, PC Investigating Nymox Pharmaceutical Corporation for Failing to Disclose Material Information 2Cohen, Placitella & Roth, PC Investigating Nymox Pharmaceutical Corporation for Failing to Disclose Material Information 3
Cached News: