HOME >> MEDICINE >> NEWS
Major discovery raises prospect of better patient care by improving platelet life span

The research team led by Drs Benjamin Kile and David Huang has discovered that platelet life span is controlled by two key molecules. The discovery raises the prospect of developing a new drug to prolong the life span of platelets stored in blood banks, effectively increasing the availability of this life-saving blood product.

An undesirable side effect of cancer chemotherapy is extensive bruising and potentially life-threatening bleeding. This is caused by the unintended depletion of platelets, tiny circulating blood cells that are essential for blood clotting and wound healing. Consequently, the well being of some patients depends upon platelet transfusions, particularly during the vulnerable periods that follow anti-cancer treatment. The significant demand for high quality platelets, coupled with their short shelf life of only five days, presents major logistical challenges in clinical practice.

The scientific team has found that two specialised molecules act in opposition to each other to control platelet life span by regulating the process known as "apoptosis." This term refers to the normal and healthy self destruction of old, damaged and surplus cells. One protein (known as Bcl-xL) acts to preserve the life of the platelet, while the other protein (Bak) prepares the cell to self-destruct after its usual life span within the body - about a week.

WEHI's Dr David Huang said, "Apoptosis is an essential process, common in other cells, but the central role it plays in controlling the life span of the highly specialised platelet has not been previously appreciated. With this new knowledge, we are in a much stronger position to devise better therapies for the management of platelet-related diseases."

Dr Kile added, "For fifty years doctors have speculated about what controls platelet life span. We now know the identity of the precise molecular switch responsible. The team is now actively pursuing a drug development program
'"/>

Contact: Brad Allan
allan@wehi.edu.au
61-393-452-345
Research Australia
22-Mar-2007


Page: 1 2

Related medicine news :

1. Chinese space agency joins the International Charter Space and Major Disasters
2. Major employers, physicians, stakeholders unite to revolutionize Americas healthcare system
3. Majority of herb users dont follow evidence-based indications, researchers find
4. Majority of state Medicaid programs have or plan to have pay-for-performance programs
5. Major visual disorders in people over 40 may be costing the US economy billions
6. Major cancer study aims to identify protein markers for early-stage disease
7. Majority of health care opinion leaders say Medicare Part D helps beneficiaries, changes are needed
8. Major grant to IU School of Medicine will expand HIV/AIDS programs in Kenya
9. Major WHO study concludes calcium supplements can reduce complications during pregnancy
10. Major biomarker candidates for Alzheimers disease explored
11. Major ovarian cancer clinical study announced at Yale using combination drug therapy

Post Your Comments:
(Date:7/3/2015)... Red Deer, Alberta (PRWEB) , ... July 03, 2015 , ... ... Camp host their 24-Hour Train-a-Thon where they provide members of the Red Deer community ... This year’s full day of fitness training, games, food, events and entertainment raised thousands ...
(Date:7/2/2015)... ... ... Following the recent report by JAMA Internal Medicine published on ... Samir Becic emphatically declared a war on obesity in the United States. , "Obesity ... must understand the magnitude of this discovery. For that reason, I am declaring, along ...
(Date:7/2/2015)... ... , ... In 2012, Patrick Achebe realized that the gift of poetry was fully in him, ... his first poem, and three years later he was publishing an entire book of poetry. ... the world. "I have always believed that the best way to lift yourself up, is ...
(Date:7/2/2015)... ... ... Six months ahead of his 80th birthday, Don Stevenson has reached the ... the Pulmonary Hypertension Association (PHA). Stevenson began the walk in Washington State three ... He left Glasgow, Mont. yesterday morning and is making his way to Wolf Point. ...
(Date:7/2/2015)... CA (PRWEB) , ... July 02, 2015 , ... ... of Dr. Divakar R. Krishnareddy, M.D., to the orthopedic and spine surgery team ... disc herniations, sprains, strains, bursitis, and tendonitis. Along with the spine and spine ...
Breaking Medicine News(10 mins):Health News:Red Deer Fitness Studio Raises $10,000 for Charity Organization with 24-Hour Train-a-Thon 2Health News:Red Deer Fitness Studio Raises $10,000 for Charity Organization with 24-Hour Train-a-Thon 3Health News:Samir Becic's Health Fitness Revolution Declares War Against Obesity in America 2Health News:Samir Becic's Health Fitness Revolution Declares War Against Obesity in America 3Health News:Samir Becic's Health Fitness Revolution Declares War Against Obesity in America 4Health News:Patrick Achebe Releases Debut Book, Whispering Waves: Poems for Everyday Grace 2Health News:79-Year-old ‘Pacing Parson’ Passes 1,000-Mile Mark in Cross-Country Walk for Pulmonary Hypertension Association 2Health News:79-Year-old ‘Pacing Parson’ Passes 1,000-Mile Mark in Cross-Country Walk for Pulmonary Hypertension Association 3Health News:Healthpointe Welcomes Dr. Divakar R. Krishnareddy to its Orthopedic Team in Anaheim 2Health News:Healthpointe Welcomes Dr. Divakar R. Krishnareddy to its Orthopedic Team in Anaheim 3
(Date:7/2/2015)... 2015 According to a new market ... Stimulation, Spinal Cord Stimulation, Transcranial Magnetic Stimulation), Application (Depression, Parkinson,s, ... 2020", published by MarketsandMarkets, the global Neuromodulation Market is estimated ... $6.20 Billion by 2020, at a CAGR of 11.2% during ... 4 market data T ables and ...
(Date:7/2/2015)... , July 2, 2015 Numotion,s Board ... Officer announced that Tamas Feitel has joined ... joins Numotion after a highly successful 18 year career ... roles driving strategy, profitability, and productivity to result in ... recent position was Chief Financial Officer for GE Healthcare ...
(Date:7/2/2015)... , June 25, 2015 ... ) has announced the addition of the ... and Immunodiagnostics: Global Challenges, Emerging Technologies, Competitive ... 2015 New Frontiers in Clinical Chemistry ... Landscape is a new seven-country strategic analysis ...
Breaking Medicine Technology:Neuromodulation Market Worth $6.20 Billion by 2020 2Neuromodulation Market Worth $6.20 Billion by 2020 3Neuromodulation Market Worth $6.20 Billion by 2020 4Numotion Names Tamas Feitel Chief Financial Officer 2New Frontiers in 2015 Global Clinical Chemistry and Immunodiagnostics Market: Challenges, Emerging Technologies, Competitive Landscape 2
Cached News: