HOME >> MEDICINE >> NEWS
Mayo Clinic Cancer Center researcher finds mold by-product kills multiple myeloma

LOS ANGELES -- Mayo Clinic Cancer Center researchers have found that chaetocin, a by-product of a common wood mold, has promise as a new anti-myeloma agent. Results of their study, being presented today at the American Association for Cancer Research annual meeting, show the by-product to be more effective than currently used therapies at killing multiple myeloma cells. The complete findings are also available online in Blood.

"There were a number of fascinating findings," says Keith Bible, M.D., Ph.D., oncologist and the studys primary investigator. "In addition to observing many favorable aspects of chaetocin, we discovered some avenues for further research into other possible anti-myeloma agents."

Multiple myeloma is an incurable bone marrow cancer that kills more than 11,000 people each year in the United States, reports the American Cancer Society. Dr. Bibles team has shown for the first time that chaetocin has promising anti-myeloma activity. They found that chaetocins promise includes the ability to:

  • Kill myeloma cells harboring a diverse array of genetic abnormalities
  • Cause biological changes and induce oxidative stress in myeloma cells, leading to their death
  • Selectively kill myeloma cells with superior efficacy to commonly-used anti-myeloma drugs including dexamethasone and doxorubicin
  • Reduce myeloma growth in mice
  • Rapidly accumulate in cancer cells

The researchers were surprised that chaetocin, while structurally similar to anti-cancer agents known as histone deacetylase inhibitors (HDACIs), did not, at cytotoxic concentrations, seem to function as an HDACI; but instead that the cytotoxic mechanism appeared to be at least in part attributable to oxidative stress caused by chaetocin.

"Much more research needs to be done," says Jennifer Tibodeau, Mayo post-doctorate fellow and presenter of the study, "but we are hopeful that chaetocin may some day provide ne
'"/>

Contact: Elizabeth Zimmermann
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
15-Apr-2007


Page: 1 2

Related medicine news :

1. Clinical data suggest potential versatility of ALIMTA-based regimens in lung cancer
2. Susan G. Komen for the Cure and American Society of Clinical Oncology partner in national initiative
3. Clinical review -- A psychological approach to the management of irritable bowel syndrome
4. NHLBI Asthma Clinical Research Networks and ALA ACRC Network to present at ATS 2007
5. New Mayo Clinic MRI technology enables noninvasive liver diagnoses
6. Clinical trial data for Perforomist Inhalation Solution presented at International ATS Conference
7. Elsevier launches the Clinics on ScienceDirect
8. Clinical guidelines for blood conservation during cardiac procedures developed
9. Clinical trial data for Perforomist Inhalation Solution to be presented at ATS on May 20, 2007
10. Mayo Clinic research in cardiovascular disease presented at Experimental Biology 2007
11. Mayo Clinic study finds heart transplant patients benefit from new approach to immunosuppression

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/9/2018)... ... August 09, 2018 , ... Thanks to the ... company’s independent distributors, customers, and employees, the newly established Isagenix Legacy Foundation ... $2 million goal. 100 percent of the donations will fund grants to nonprofit ...
(Date:8/7/2018)... ... , ... Sussex Vision Center, a multi-site optometry practice with deep community roots ... practice in Coldwater, and over the last three decades has added locations in Three ... health services for patients of all ages. , “I wanted to find the ...
(Date:8/7/2018)... CHURCH, Va. (PRWEB) , ... August 07, 2018 ... ... to announce the 30 talented nursing students selected to receive the 2018 ... encourage students to experience the rewarding field of psychiatric-mental health nursing and develop ...
(Date:8/3/2018)... ... August 03, 2018 , ... On August 2, 2018 the ... Mark Sadaka of Sadaka Associates, LLC has been litigating Zostavax injuries ... the Judicial Panel on Multidistrict Litigation for the thousands of people injured by Zostavax, ...
(Date:8/3/2018)... (PRWEB) , ... August 03, 2018 , ... ... spectacles and smartglasses, is pleased to announce the launch of its online store. ... Lucyd-developed smartglasses, designer frames, and other innovations in spectacles. , The eShop ...
Breaking Medicine News(10 mins):
(Date:8/11/2018)... (PRWEB) , ... August 11, 2018 , ... ... a new episode of ‘Information Matrix’ on integrative medicine. The episode will go ... people in the society. , Integrative medicine involves using both conventional and complementary ...
(Date:8/9/2018)... ... , ... Doctor Snehal Patel is offering the residents of South Fairfax County ... 30th, applicants who are in need of full-arch restorations, but who otherwise couldn’t afford ... Smile Program. , "Our local communities have been very good to us and we ...
(Date:8/7/2018)... ... August 07, 2018 , ... Braun Ambulances is honored to announce ... Bailey Hutchison Convention Center in Dallas, Texas. Braun Ambulances will have four units on ... model. , Fire Rescue International (FRI) is the International Association of Fire Chiefs’ ...
Breaking Medicine Technology:
Cached News: