HOME >> MEDICINE >> NEWS
Mayo Clinic Cancer Center researcher finds mold by-product kills multiple myeloma

LOS ANGELES -- Mayo Clinic Cancer Center researchers have found that chaetocin, a by-product of a common wood mold, has promise as a new anti-myeloma agent. Results of their study, being presented today at the American Association for Cancer Research annual meeting, show the by-product to be more effective than currently used therapies at killing multiple myeloma cells. The complete findings are also available online in Blood.

"There were a number of fascinating findings," says Keith Bible, M.D., Ph.D., oncologist and the studys primary investigator. "In addition to observing many favorable aspects of chaetocin, we discovered some avenues for further research into other possible anti-myeloma agents."

Multiple myeloma is an incurable bone marrow cancer that kills more than 11,000 people each year in the United States, reports the American Cancer Society. Dr. Bibles team has shown for the first time that chaetocin has promising anti-myeloma activity. They found that chaetocins promise includes the ability to:

  • Kill myeloma cells harboring a diverse array of genetic abnormalities
  • Cause biological changes and induce oxidative stress in myeloma cells, leading to their death
  • Selectively kill myeloma cells with superior efficacy to commonly-used anti-myeloma drugs including dexamethasone and doxorubicin
  • Reduce myeloma growth in mice
  • Rapidly accumulate in cancer cells

The researchers were surprised that chaetocin, while structurally similar to anti-cancer agents known as histone deacetylase inhibitors (HDACIs), did not, at cytotoxic concentrations, seem to function as an HDACI; but instead that the cytotoxic mechanism appeared to be at least in part attributable to oxidative stress caused by chaetocin.

"Much more research needs to be done," says Jennifer Tibodeau, Mayo post-doctorate fellow and presenter of the study, "but we are hopeful that chaetocin may some day provide ne
'"/>

Contact: Elizabeth Zimmermann
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
15-Apr-2007


Page: 1 2

Related medicine news :

1. Clinical data suggest potential versatility of ALIMTA-based regimens in lung cancer
2. Susan G. Komen for the Cure and American Society of Clinical Oncology partner in national initiative
3. Clinical review -- A psychological approach to the management of irritable bowel syndrome
4. NHLBI Asthma Clinical Research Networks and ALA ACRC Network to present at ATS 2007
5. New Mayo Clinic MRI technology enables noninvasive liver diagnoses
6. Clinical trial data for Perforomist Inhalation Solution presented at International ATS Conference
7. Elsevier launches the Clinics on ScienceDirect
8. Clinical guidelines for blood conservation during cardiac procedures developed
9. Clinical trial data for Perforomist Inhalation Solution to be presented at ATS on May 20, 2007
10. Mayo Clinic research in cardiovascular disease presented at Experimental Biology 2007
11. Mayo Clinic study finds heart transplant patients benefit from new approach to immunosuppression

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/8/2019)... ... October 08, 2019 , ... ... in live samples, Meiqing Shi, associate professor with the University of Maryland Department ... latest paper published in Nature Communications, Shi and his lab have discovered a ...
(Date:10/8/2019)... ... October 08, 2019 , ... At ... 4medica® President Gregg Church will inform conference attendees how the ... orders management-by starting with the right, clean patient data. The single platform interfaces ...
(Date:10/8/2019)... Ark. (PRWEB) , ... October 08, 2019 , ... ... has selected CardioWise, Inc. a Digital Health Awards 1st Round (Top ... UCSF Digital Health Awards was to select companies that promote faster, better, more ...
(Date:10/8/2019)... ... ... husband and wife dental team, Dr.’s Michael and Azita Mansouri, will open their Marietta practice ... that Mansouri Family Dental Care & Associates has held the event to support ... great turnout, serving over 300 people in a single day in the past. Doors will ...
(Date:10/8/2019)... ... October 08, 2019 , ... U.S. ... Texas, that exclusively serves premier oral and maxillofacial surgeons – has formed a ... surgery practice with two locations near Knoxville, Tennessee. The partnership is USOSM’s first ...
Breaking Medicine News(10 mins):
(Date:10/15/2019)... Calif. (PRWEB) , ... October 14, 2019 , ... An ... to the mounting evidence suggesting a correlation between tooth loss and heart disease. The ... teeth had a 28 percent chance of also having heart-related problems, compared to just ...
(Date:10/11/2019)... N.Y. (PRWEB) , ... October 11, 2019 , ... ... — the regulated cannabis industry’s national resource — held the grand opening for ... New York, STOA Wellness offers a thoughtfully curated lineup of CBD wellness products ...
(Date:10/10/2019)... , ... October 10, 2019 , ... Smile Brands Inc. ... Misono in Natomas, California and opening of a new A+ location in Natomas. , ... locations across the Sacramento area. The group’s 14 general dentists and three specialists work ...
Breaking Medicine Technology:
Cached News: