Mayo Clinic finding may double genetic screening effectiveness for sudden death heart...( tudy The researchers examined 382 u...),Health

tudy
The researchers examined 382 unrelated patients in the Mayo Clinic Hypertrophic Cardiomyopathy Clinic over a four-year period, analyzing eight known HCM-susceptibility genes. These eight genes comprise the available clinical genetic test for HCM. Next -- and without prior knowledge of the results of the patients' genetic profiles -- the researchers evaluated traditional medical exam data, including patient medical history, and anatomical and functional findings, such as blood pressure and echocardiography images. Echocardiography is a common noninvasive way to make a moving picture of the heart's structure and function using ultrasound. It transmits sound waves through the heart and records them on an electronic sensor to create a moving picture.

Findings
In the final step, the researchers matched the gene screening results to traditional exam results -- and found a consistent correlation between heart muscle shape and the presence of HCM-associated mutations. Regardless of age, if the heart muscle had the sigmoid shape, the yield of the genetic test was only 8 percent compared to 79 percent when the shape was reverse curvature. Collaboration and Support

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Contact: Traci Klein
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
19-Apr-2006

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