HOME >> MEDICINE >> NEWS
Mayo Clinic research shows young people who died suddenly and inexplicably had genetic heart defects

ROCHESTER, Minn. -- In 49 young people who died suddenly and inexplicably at an average age of 14, conventional autopsies found no cause of death. But when Mayo Clinic researchers conducted a sophisticated form of postmortem genetic testing -- known as a molecular autopsy -- they found that more than one-third died due to potentially heritable genetic defects that impair the heart's rhythm center.

The defects were caused by mutations, which can be thought of as spelling errors in the genetic code. The defects produced one of two abnormal heart rhythm conditions: Long QT syndrome (LQTS) and catecholaminergic polymorphic ventricular tachycardia (CPVT). Both syndromes can declare their presence silently and catastrophically with a sudden death episode as the first symptom. Because they leave no structural or physical clues, the defects can't be detected with conventional autopsy methods -- so families have been left with the additional grief of wondering what caused the premature death.

Mayo Clinic's molecular autopsy is a detailed examination at a molecular level of heart function. Molecular autopsies can help lessen grief burden of families because data show that they exposed the lethal mutations as the cause of death in 35 percent of cases in which conventional autopsies could not ascertain cause of death. "The fact that conventional autopsy fails to provide an answer is, in fact, a key clue that the killer may be LQTS or CPVT," says Michael J. Ackerman, M.D., Ph.D., the study's chief author who heads the Mayo Clinic Windland Smith Rice Sudden Death Genomics Laboratory.

"To prevent further tragic, premature deaths, the standard of care for the evaluation of sudden unexplained death must now change. Surviving members in a family in which there's been this tragedy should receive medical attention that is equal to a ‘full-court press,'" Dr. Ackerman says. "It must involve a careful and sleuth-like search for these inherited glitches in
'"/>

Contact: Traci Klein
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
30-Jan-2007


Page: 1 2 3

Related medicine news :

1. Clinical data suggest potential versatility of ALIMTA-based regimens in lung cancer
2. Susan G. Komen for the Cure and American Society of Clinical Oncology partner in national initiative
3. Clinical review -- A psychological approach to the management of irritable bowel syndrome
4. NHLBI Asthma Clinical Research Networks and ALA ACRC Network to present at ATS 2007
5. New Mayo Clinic MRI technology enables noninvasive liver diagnoses
6. Clinical trial data for Perforomist Inhalation Solution presented at International ATS Conference
7. Elsevier launches the Clinics on ScienceDirect
8. Clinical guidelines for blood conservation during cardiac procedures developed
9. Clinical trial data for Perforomist Inhalation Solution to be presented at ATS on May 20, 2007
10. Mayo Clinic research in cardiovascular disease presented at Experimental Biology 2007
11. Mayo Clinic study finds heart transplant patients benefit from new approach to immunosuppression

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/21/2020)... Mass. (PRWEB) , ... May 21, 2020 , ... ... of its award-winning population health management platform that supports care management and utilization ... than 100 individuals at client sites, TruCare 2020 provides significant usability and automation ...
(Date:5/21/2020)... ... ... JNL Technologies Inc. , a manufacturer of safety and security products ... screening software. This tool allows companies to create an electronic screening record of anyone ... paperwork management. , SafeHealth allows you to create a custom set of screening questions, ...
(Date:5/16/2020)... ... ... patients who have gone to see Andy Gaertner, D.M.D , in the past, they ... After being allowed to re-open during the current pandemic, they have put some new protocols ... comfortable as possible while going through their dental exams and treatments. , The new protocols ...
(Date:5/16/2020)... YORK (PRWEB) , ... May 15, 2020 , ... ... has announced a new collaboration with the Open Source Medical Supplies (OSMS). The ... support of their efforts to reduce the spread of COVID-19. , Created as ...
(Date:5/15/2020)... ... May 15, 2020 , ... COVID-19 has made people feel fearful, but Rieke ... their employees can get back to work safely. Their unique line of SafeSpace™ PPE ... bars, and countless other settings. , Everyone needs to be able to get back ...
Breaking Medicine News(10 mins):
(Date:5/25/2020)... ... May 24, 2020 , ... May ... Obispo electricians, want the public to know what safety resources are available. Every ... International (ESFI) launches an education campaign to inform the public about safety steps ...
(Date:5/21/2020)... ... May 21, 2020 , ... Latham ... to help manufacture 25,000 polymer film gowns that will be worn by doctors ... residential swimming pools and accessories, is excited to give back to the community ...
(Date:5/21/2020)... ... May 21, 2020 , ... In today’s news cycle we ... to touch or shake hands with others; to avoid restaurants, movie theaters, concerts, sporting ... with your Netflix, AppleTV+, YoutubeTV or Prime Video subscriptions. But as things begin to ...
Breaking Medicine Technology:
Cached News: