Mayo researchers discover overdiagnosis of long QT heart syndrome

ROCHESTER, Minn. -- Congenital long QT syndrome (LQTS) can be lethal if not diagnosed -- yet recent increased awareness of the disorder may lead to diagnosing patients when they dont have the syndrome and then prescribing treatments that restrict patients lifestyles, a new Mayo Clinic study shows.

In their review of 176 patients referred to Mayo Clinic for a second opinion about a diagnosis of LQTS, Mayo specialists found that about 40 percent did not show sufficient evidence to merit that diagnosis. Most of these were dismissed as normal. Of the 176, most were taking drugs to correct a presumed LQTS problem and were restricted from strenuous physical activity, including competitive sports. About 10 percent had undergone surgery to have an implantable cardioverter defibrillator (ICD), a treatment for LQTS.

Two of every five patients who were referred to us with the diagnosis of LQTS left Mayo Clinic without the diagnosis, explains Michael Ackerman, M.D., Ph.D., the pediatric cardiologist who directs Mayos Long QT Syndrome Clinic and is the director of the Mayo Clinic Windland Smith Rice Sudden Death Genomics Laboratory. He is the senior author of a study that appeared in the May 22 issue of Circulation.

This is dramatic evidence of just how challenging LQTS is to correctly diagnose because it can present with such a large variety of symptoms, Dr. Ackerman says. Theres a real need for cautious, comprehensive evaluation by experienced LQTS specialists because there is a risk for overdiagnosis. And when that happens, some of the treatments that patients may receive when they carry this diagnosis -- such as taking medications for life, having a defibrillator implanted, or being restricted from competitive sports -- can have a profound effect on quality of life.

Dr. Ackerman emphasizes that this subset of patients seen at Mayo Clinic may not be representative of all LQTS patients. Their cases may not have been clear in the fi

Contact: Traci Klein
Mayo Clinic

Page: 1 2 3

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. UCLA researchers awarded $9M contract for study identifiying antibiotic treatment for MRSA
3. Penn researchers discover novel pathway for increasing good cholesterol
4. Theory of facial aging gets a facelift from UT Southwestern researchers
5. UIC researchers to develop new drugs to fight bioterrorism
6. UQ researchers discover some of the oldest forms of life
7. U of M researchers discover new method to combat HIV
8. U of M researchers assess effectiveness of computerized physician order entry system
9. Nepalese researchers identify cost-effective treatment for drug-resistant typhoid
10. Physician-researchers often less successful in obtaining NIH funding
11. UCLA researchers develop new nanomaterials to deliver anti-cancer drugs to cells

Post Your Comments:

(Date:10/13/2017)... ... October 13, 2017 , ... Many families have long-term insurance that covers ... companies have a waiver for care if the client has a cognitive impairment diagnosis. ... pays for care, is often waived, so the benefits from their insurance start immediately,” ...
(Date:10/13/2017)... ... October 13, 2017 , ... Talented host, ... lowdown on sciatica in a new episode of "Success Files," which is an ... and innovation and investigates each subject in-depth with passion and integrity. , Sciatica ...
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent and San ... using cutting-edge Oventus O2Vent technology. As many as 18 million Americans are ... cessation in breathing. Oral appliances can offer significant relief to about 75 percent ...
(Date:10/12/2017)... ... ... Asante, a nationally recognized health system in southern Oregon, ... health joint venture through an agreement, effective October 1, 2017, to create AccentCare ... company with Asante, delivering clinically integrated care, for the past eight years. This ...
(Date:10/12/2017)... ... October 12, 2017 , ... On Saturday, October 21, ... relay – Miles by Moonlight to raise money for the American Heart Association Heart ... , Teams will work together to keep their treadmills moving for 5 hours. ...
Breaking Medicine News(10 mins):
(Date:9/19/2017)... 19, 2017   ZirMed Inc ., a recognized leader ... that it has been ranked #1 by its users for ... Rankings 2017 User Survey. ZirMed was recognized as the top-ranked ... and medical centers over 200 beds and holds one of ... user survey history. ...
(Date:9/13/2017)...   OrthoAtlanta has been named the official orthopedic ... (AFHC) for the 2018 College Football Playoff (CFP) National Championship ... Stadium in Atlanta, Georgia . OrthoAtlanta is ... campaign, participating in many activities leading up to, and including ... ...
(Date:9/12/2017)... FRANCISCO , Sept. 12, 2017  ValGenesis ... Management Solutions (VLMS), is pleased to announce the ... a member of its Board of Directors and ... ValGenesis VLMS enables life science companies to manage ... the use of paper in this process. Furthermore, ...
Breaking Medicine Technology:
Cached News: