HOME >> MEDICINE >> NEWS
Measuring certain enzyme activity in urine shows promise for detection of bladder cancer

Measurement of an enzyme level (telomerase activity) in urine appears useful for detection of bladder cancer in men, according to a study in the October 26 issue of JAMA.

The incidence of human bladder cancer has greatly increased over the last few decades, with more than 60,000 new cases diagnosed each year in the United States alone, and now represents the 4th most common malignancy in men and the 10th most common in women, according to background information in the article. At present, about 20 percent of patients die each year, but when the disease is diagnosed and treated in the early stage, the chances of survival are good, indicating the importance of a timely and accurate diagnosis.

Established approaches for detecting bladder cancer are either invasive and costly or have limited sensitivity, highlighting the need for the development of a noninvasive, reliable, and simple test to increase the rate of detection of bladder cancer. Among the markers investigated for this purpose has been telomerase (a certain enzyme) activity in urine.

Maria Aurora Sanchini, M.Sc., of Morgagni-Pierantoni Hospital, Forl, Italy, and colleagues conducted a study to define the diagnostic accuracy of different telomerase activity cutoff values in terms of sensitivity and specificity. The study included 218 men (84 healthy individuals and 134 patients at first diagnosis of histologically confirmed bladder cancer), recruited between March 2003 and November 2004 in Italy. Urine telomerase activity was determined using a highly sensitive telomeric repeat amplification protocol (TRAP) assay. Urine samples were processed for cytological (cell) diagnosis and TRAP assay. The diagnosis of bladder cancer was based on bioptic and cystoscopic examinations (direct visual examination of the urinary tract). The performance of the TRAP assay to detect urine telomerase activity was compared to urine cytology as an aid to early cancer detection.

Using a 50 arbitrary e
'"/>

Contact: Daniele Calistri, Ph.D.
biomolec@ausl.fo.it
JAMA and Archives Journals
25-Oct-2005


Page: 1 2 3

Related medicine news :

1. Measuring lung motion leads to better radiation treatment for lung cancer
2. Measuring brain activity for emotional markers that may indicate risk for developing alcoholism
3. Measuring proteins in spinal fluid may provide early clue to Alzheimers disease
4. Measuring artery repair cells could become new heart disease test
5. Measuring hormone cuts antibiotic use in half in pneumonia patients
6. Measuring enzymes at end of cancer pathway predicts outcome of Tarceva, Taxol
7. Antifolate therapies found effective against certain type of malaria
8. Low-glycemic load diet may be more effective for dieters with certain insulin response patterns
9. No increased risk of certain cancers from electromagnetic fields among energy workers
10. Concentrations of certain toxins in breast milk are low, study finds
11. Improved adherence to certain medications associated with longer survival following heart attack

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/23/2017)... ... August 23, 2017 , ... ... Development and Sector Growth. Mr. Smith joins other recent high-profile hires including Frank ... Smith’s healthcare career began in 1993, helping physician practices and hospitals automate their ...
(Date:8/23/2017)... ... , ... Earlier this month, the Workgroup for Electronic Data Interchange (WEDI) ... efficiencies in healthcare information exchange and a trusted advisor to the U.S. Department of ... keynote addresses by Donald W. Rucker, MD, head of the Office of the National ...
(Date:8/23/2017)... ... August 23, 2017 , ... CEFEX, the Centre for ... the standards representing best practices in the retirement plan industry. The independent CEFEX ... helps to verify that NFP’s retirement division focuses on putting clients’ interests first ...
(Date:8/23/2017)... ... August 23, 2017 , ... Nightingale College continues the semiannual Give Back ... a time Nightingale College dedicates to serving and volunteering for organizations that provide indispensable ... volunteers or those that need a little extra help. , The College’s Give ...
(Date:8/23/2017)... ... August 23, 2017 , ... Cirrus Medical ... a new website, http://www.cirrusmedicalstaffing.com . The new site pairs a robust job ... healthcare professionals who are traveling on short-term assignments to healthcare facilities around the ...
Breaking Medicine News(10 mins):
(Date:8/8/2017)... 8, 2017  BioLineRx Ltd. (NASDAQ/TASE: BLRX), a clinical-stage ... its financial results for the second quarter ended June ... second quarter 2017 and to date: ... programs for the Company,s lead project, BL-8040: ... with BL-8040 as novel stem cell mobilization treatment for ...
(Date:8/7/2017)... Mich. , Aug. 7, 2017 Diplomat Pharmacy, ... of Joel Saban as president, effective Aug. 7, ... Urick has decided to pursue other interests and will ... "During his tenure, Paul has served us in multiple leadership ... Specialty Pharmacy in Jun. 2015 and has provided decisive, strategic ...
(Date:8/4/2017)... , Aug. 3, 2017  Agragen, LLC, a ... active in the biopharmaceutical, nutraceutical, and aquacultural feed ... of its lead drug candidates, AGR131.  This drug ... cytokine from the blood of patients suffering from ... inflammatory bowel disease. ...
Breaking Medicine Technology:
Cached News: