HOME >> MEDICINE >> NEWS
Measuring certain enzyme activity in urine shows promise for detection of bladder cancer

Measurement of an enzyme level (telomerase activity) in urine appears useful for detection of bladder cancer in men, according to a study in the October 26 issue of JAMA.

The incidence of human bladder cancer has greatly increased over the last few decades, with more than 60,000 new cases diagnosed each year in the United States alone, and now represents the 4th most common malignancy in men and the 10th most common in women, according to background information in the article. At present, about 20 percent of patients die each year, but when the disease is diagnosed and treated in the early stage, the chances of survival are good, indicating the importance of a timely and accurate diagnosis.

Established approaches for detecting bladder cancer are either invasive and costly or have limited sensitivity, highlighting the need for the development of a noninvasive, reliable, and simple test to increase the rate of detection of bladder cancer. Among the markers investigated for this purpose has been telomerase (a certain enzyme) activity in urine.

Maria Aurora Sanchini, M.Sc., of Morgagni-Pierantoni Hospital, Forl, Italy, and colleagues conducted a study to define the diagnostic accuracy of different telomerase activity cutoff values in terms of sensitivity and specificity. The study included 218 men (84 healthy individuals and 134 patients at first diagnosis of histologically confirmed bladder cancer), recruited between March 2003 and November 2004 in Italy. Urine telomerase activity was determined using a highly sensitive telomeric repeat amplification protocol (TRAP) assay. Urine samples were processed for cytological (cell) diagnosis and TRAP assay. The diagnosis of bladder cancer was based on bioptic and cystoscopic examinations (direct visual examination of the urinary tract). The performance of the TRAP assay to detect urine telomerase activity was compared to urine cytology as an aid to early cancer detection.

Using a 50 arbitrary e
'"/>

Contact: Daniele Calistri, Ph.D.
biomolec@ausl.fo.it
JAMA and Archives Journals
25-Oct-2005


Page: 1 2 3

Related medicine news :

1. Measuring lung motion leads to better radiation treatment for lung cancer
2. Measuring brain activity for emotional markers that may indicate risk for developing alcoholism
3. Measuring proteins in spinal fluid may provide early clue to Alzheimers disease
4. Measuring artery repair cells could become new heart disease test
5. Measuring hormone cuts antibiotic use in half in pneumonia patients
6. Measuring enzymes at end of cancer pathway predicts outcome of Tarceva, Taxol
7. Antifolate therapies found effective against certain type of malaria
8. Low-glycemic load diet may be more effective for dieters with certain insulin response patterns
9. No increased risk of certain cancers from electromagnetic fields among energy workers
10. Concentrations of certain toxins in breast milk are low, study finds
11. Improved adherence to certain medications associated with longer survival following heart attack

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2017)... ... 25, 2017 , ... With a heatwave currently bearing down on Northern California pushing temperatures to ... Being swimsuit ready is easy with laser hair removal. , The process of summer ... burdensome routine when all you want to do is get out, dive in and cool ...
(Date:6/24/2017)... ... ... The weather is heating up and the days are getting longer, providing ... that the summer months provide more than warmer temperatures that are perfect for BBQ’s ... affected from direct exposure to the sun. When it comes to the security of ...
(Date:6/23/2017)... MA (PRWEB) , ... June 23, 2017 , ... ... Care Reconciliation Act (BCRA), their proposed healthcare bill to repeal and replace the ... May, the Senate bill would make significant cuts to Medicaid, a public health ...
(Date:6/23/2017)... ... June 23, 2017 , ... Everybody has their own personal preference ... to read it, and some people don't like it at all. FindaTopDoc took a ... found: , Erotic literature can give readers a taste of their deepest, darkest fantasies ...
(Date:6/23/2017)... ... ... 21 Middle East and South Asia Leaders Selected as Eisenhower Fellows ... civil society in 11 countries across the Middle East and South Asia to embark ... of knowledge and ideas with the leading minds in their fields. , For ...
Breaking Medicine News(10 mins):
(Date:6/10/2017)... , June 9, 2017  Shane K. Burchfield, DPM, is recognized ... excellence as a Podiatrist in Alabama . ... Family First Foot Care. He brings over 20 years of experience, ... management and healthcare, to his role. ... Care, PC is pleased to welcome you to his ...
(Date:6/8/2017)... --  Responding to Heath Ledger,s father,s recent call ... Chris Cornell in May, the mental health watchdog ... online psychiatric drug side effects search engine ... drug risks. The father of the late ... overdose, has called for tighter rules on prescription drugs. Speaking ...
(Date:6/7/2017)... 6, 2017  Diplomat Specialty Infusion Group, a brand of Diplomat ... its Iowa location. The ... now features an ISO 7 cleanroom—the standard needed to compound intravenous ... low level of pollutants. "Our ... and better serve our Iowa patients," said ...
Breaking Medicine Technology:
Cached News: