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Measuring hormone cuts antibiotic use in half in pneumonia patients

SAN DIEGO-Measuring a hormone in the blood can help doctors greatly reduce the number of days pneumonia patients have to take antibiotics to cure their infection, according to a study to be presented at the American Thoracic Society International Conference on May 24.

In the study, pneumonia patients whose level of the hormone procalcitonin was measured during the course of their illness took antibiotics an average of 6 days, compared with 12 days for patients whose procalcitonin levels were not measured. Fifteen percent of patients whose hormone levels were measured did not have to take antibiotics at all, said study co-author Michael Tamm, M.D., Chief of Pulmonary Medicine and Pulmonary Cell Research at University Hospital in Basel, Switzerland.

"Because of concerns about antibiotic resistance, as well as the cost of antibiotics, it's always better to give fewer antibiotics," Prof. Tamm said.

Many cases of community-acquired pneumonia are caused by bacteria, which require treatment with antibiotics, but some cases are viral, which get better without antibiotics. But doctors don't like to delay treatment in order to wait for lab results to tell them whether a patient's pneumonia is bacterial or viral, so they start all patients on antibiotics, Dr. Tamm said. "Once the treatment is started, it is usually continued for 10 to 14 days, because nobody knows when you can stop without a risk for the patient," he said.

Because levels of procalcitonin have been found to be elevated in patients with bacterial infection but not viral infection or other inflammatory diseases, Dr. Tamm and colleagues decided to study whether measuring levels of the hormone could eliminate or reduce antibiotic use in patients with bacterial pneumonia. Results of the blood test that measures procalcitonin levels can be obtained in only one hour, he said.

They studied more than 300 patients with community-acquired pneumonia (pneumonia that is not caught whil
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Contact: Jim Augustine
619-525-6216
American Thoracic Society
24-May-2005


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