HOME >> MEDICINE >> NEWS
Measuring proteins in spinal fluid may provide early clue to Alzheimer's disease

Chicago Early signs of the development of Alzheimer's disease can be seen in the cerebrospinal fluid of middle-aged adults who are genetically predisposed to the neurologic condition, according to a report in the July issue of Archives of Neurology, one of the JAMA/Archives journals.

The two strongest risk factors for Alzheimer's disease are aging and the presence of an allele (type of gene) known as apolipoprotein E*4 (APOE*4), according to background information in the article. Those with the APOE*4 allele develop clinical dementia about 10 to 15 years earlier than those who do not have the APOE*4 allele. Previous studies have shown that the plaques that form in the brain during Alzheimer's disease, which are made of proteins known as -amyloids, begin forming years before affected individuals experience any symptoms of the disease. As -amyloid proteins, predominately of a type known as A42, clump together, fewer are available to circulate through the nervous system. Therefore, lower levels of the A42 in the cerebrospinal fluid surrounding the brain and spinal cord serve as biomarkers or chemical indicators of the development of Alzheimer's disease.

Elaine R. Peskind, M.D., VA Puget Sound Health Care System and University of Washington School of Medicine, Seattle, and colleagues estimated the combined effect of aging and the APOE*4 allele on levels of A42 and another -amyloid, A40, in 184 adults (94 men and 90 women, average age 50 years). The participants underwent clinical and laboratory screening and were found to be cognitively normal--that is, they had no difficulties with thinking, learning or memory. Researchers took samples of cerebrospinal fluid in the morning after an overnight fast and measured participants' A42 and A40 levels in addition to determining whether each individual had the APOE*4 allele.

Those who were older and who had the APOE*4 allele were more likely to have lower levels of A42. For those who did n
'"/>

Contact: Jeri Rowe
206-764-2589
JAMA and Archives Journals
10-Jul-2006


Page: 1 2

Related medicine news :

1. Measuring lung motion leads to better radiation treatment for lung cancer
2. Measuring brain activity for emotional markers that may indicate risk for developing alcoholism
3. Measuring artery repair cells could become new heart disease test
4. Measuring certain enzyme activity in urine shows promise for detection of bladder cancer
5. Measuring hormone cuts antibiotic use in half in pneumonia patients
6. Measuring enzymes at end of cancer pathway predicts outcome of Tarceva, Taxol
7. Penn study finds pro-death proteins required to regulate healthy immune function
8. Head and neck cancer vaccine targets proteins to create immune response
9. Sticky proteins provide new insight into drug action
10. First major study of mammalian disorderly proteins
11. Keep the baby, toss the bathwater: How kidneys retain proteins, discard waste

Post Your Comments:
(Date:8/28/2015)... , ... August 28, 2015 , ... ... Malaria Day at the Zoo to celebrate children helping children, a thank you ... congregations throughout West Ohio have contributed to the United Methodist initiative to end ...
(Date:8/28/2015)... ... August 28, 2015 , ... ... and Best Practices for Compliance, **Presented by FDAnews and GessNet**, Oct. 14-15, ... internationally renowned expert Fubin Wu, has been specifically designed to provide devicemakers ...
(Date:8/28/2015)... ... 2015 , ... Saint Petersburg, FL —Pocket Protein™, a protein ... sugar, gluten, lactose or caffeine in a convenient 2 oz. pouch that never ... Choice Awards. , Five consumer packaged goods (CPG) products were selected by the ...
(Date:8/28/2015)... ... August 28, 2015 , ... The Nashville Business Journal ... leading in business. Mr. Troy Mizell, Chairman of the Board at MyGenetx, ... Journal's 2015 Veterans Awards will recognize Nashville military veterans who, through their professional ...
(Date:8/28/2015)... ... August 28, 2015 , ... Northridge dentists Dr. ... whitening. For just $199, patients can currently receive a one hour treatment of this ... procedures, but it includes a number of unique features that can turn teeth up ...
Breaking Medicine News(10 mins):Health News:Saturday’s United Methodist Event at Columbus Zoo Celebrates Imagine No Malaria 2Health News:Saturday’s United Methodist Event at Columbus Zoo Celebrates Imagine No Malaria 3Health News:FDAnews Announces — Software and Cybersecurity Risk Management for Medical Devices: Understanding the FDA’s Position and Best Practices for Compliance, Oct. 14-15 2Health News:FDAnews Announces — Software and Cybersecurity Risk Management for Medical Devices: Understanding the FDA’s Position and Best Practices for Compliance, Oct. 14-15 3Health News:FDAnews Announces — Software and Cybersecurity Risk Management for Medical Devices: Understanding the FDA’s Position and Best Practices for Compliance, Oct. 14-15 4Health News:FDAnews Announces — Software and Cybersecurity Risk Management for Medical Devices: Understanding the FDA’s Position and Best Practices for Compliance, Oct. 14-15 5Health News:Pocket Protein™ Named 2015 CPG Editor’s Choice Award Finalist by Informa’s SupplySide 2Health News:Pocket Protein™ Named 2015 CPG Editor’s Choice Award Finalist by Informa’s SupplySide 3Health News:MyGenetx Board Member Receives Veterans Award 2Health News:Northridge Dentists Dr. Elyson and Dr. Assili Now Offer a Special Promotion on Zoom Teeth Whitening 2
(Date:8/27/2015)... Va. , Aug. 27, 2015  The ... the Food and Drug Administration,s (FDA,s) draft guidance ... reference products and biosimilars, to bear a nonproprietary ... AMCP has been seeking a decision from the ... 18 diverse health care stakeholders urging the agency ...
(Date:8/27/2015)... RIVERSIDE, Calif. , Aug. 27, 2015 /PRNewswire/ ... important milestone in the commercial development of the ... . The Smart Oxygen device, being developed by ... adjusts to a patient,s changing demand for oxygen ... that the 510 (k) submission for the Smart ...
(Date:8/27/2015)... Grow , the fastest-growing professional networking organization for women leaders ... World Congress & Business Exposition (CWCBExpo) in ... CWCBExpo in LA will take place September 16-18, 2015 at ... Los Angeles, CA , and is the ... industry. The Women Grow tracks at CWCBExpo ...
Breaking Medicine Technology:AMCP Is Disappointed in FDA's Draft Guidance and Proposed Rule Calling for Suffix on Nonproprietary Names of Biological Products 2Smart Oxygen Solutions' Supplemental Oxygen Delivery Device Achieves FDA Regulatory Pathway Milestone 2Smart Oxygen Solutions' Supplemental Oxygen Delivery Device Achieves FDA Regulatory Pathway Milestone 3Smart Oxygen Solutions' Supplemental Oxygen Delivery Device Achieves FDA Regulatory Pathway Milestone 4Cannabis World Congress in Los Angeles Boasts Women Grow Sponsored Education 2Cannabis World Congress in Los Angeles Boasts Women Grow Sponsored Education 3Cannabis World Congress in Los Angeles Boasts Women Grow Sponsored Education 4
Cached News: