HOME >> MEDICINE >> NEWS
Measuring proteins in spinal fluid may provide early clue to Alzheimer's disease

Chicago Early signs of the development of Alzheimer's disease can be seen in the cerebrospinal fluid of middle-aged adults who are genetically predisposed to the neurologic condition, according to a report in the July issue of Archives of Neurology, one of the JAMA/Archives journals.

The two strongest risk factors for Alzheimer's disease are aging and the presence of an allele (type of gene) known as apolipoprotein E*4 (APOE*4), according to background information in the article. Those with the APOE*4 allele develop clinical dementia about 10 to 15 years earlier than those who do not have the APOE*4 allele. Previous studies have shown that the plaques that form in the brain during Alzheimer's disease, which are made of proteins known as -amyloids, begin forming years before affected individuals experience any symptoms of the disease. As -amyloid proteins, predominately of a type known as A42, clump together, fewer are available to circulate through the nervous system. Therefore, lower levels of the A42 in the cerebrospinal fluid surrounding the brain and spinal cord serve as biomarkers or chemical indicators of the development of Alzheimer's disease.

Elaine R. Peskind, M.D., VA Puget Sound Health Care System and University of Washington School of Medicine, Seattle, and colleagues estimated the combined effect of aging and the APOE*4 allele on levels of A42 and another -amyloid, A40, in 184 adults (94 men and 90 women, average age 50 years). The participants underwent clinical and laboratory screening and were found to be cognitively normal--that is, they had no difficulties with thinking, learning or memory. Researchers took samples of cerebrospinal fluid in the morning after an overnight fast and measured participants' A42 and A40 levels in addition to determining whether each individual had the APOE*4 allele.

Those who were older and who had the APOE*4 allele were more likely to have lower levels of A42. For those who did n
'"/>

Contact: Jeri Rowe
206-764-2589
JAMA and Archives Journals
10-Jul-2006


Page: 1 2

Related medicine news :

1. Measuring lung motion leads to better radiation treatment for lung cancer
2. Measuring brain activity for emotional markers that may indicate risk for developing alcoholism
3. Measuring artery repair cells could become new heart disease test
4. Measuring certain enzyme activity in urine shows promise for detection of bladder cancer
5. Measuring hormone cuts antibiotic use in half in pneumonia patients
6. Measuring enzymes at end of cancer pathway predicts outcome of Tarceva, Taxol
7. Penn study finds pro-death proteins required to regulate healthy immune function
8. Head and neck cancer vaccine targets proteins to create immune response
9. Sticky proteins provide new insight into drug action
10. First major study of mammalian disorderly proteins
11. Keep the baby, toss the bathwater: How kidneys retain proteins, discard waste

Post Your Comments:
(Date:10/31/2014)... Alabama (PRWEB) October 31, 2014 ... emergency physician, knows all too well the chaos that ... for the end-of-life. “The vast majority of Americans who ... their own lives are completely unprepared for the moment ... the ListStuffFast app can serve as a catalyst for ...
(Date:10/31/2014)... Energy Textiles has recently added a new ... now available online, and Energy Textile is providing their ... athletic gear over compression gear. , The Boston ... signed for Under Armour to provide team gear for ... In light of this decision, Energy Textiles contemplates whether ...
(Date:10/31/2014)... suggests that insomnia is a major contributor to deaths ... injuries. The results underscore the importance of the "Sleep ... Awareness Project. , Results show that the risk of ... the number of insomnia symptoms present. People with all ... to die from a fatal injury than those with ...
(Date:10/31/2014)... October 31, 2014 North Shore Eye ... Garden City, Long Island and the addition of leading ... staff, according to North Shore Eye Care Medical Director, ... Acting Chairman of the Department of Ophthalmology of Winthrop-University ... in Garden City for more than 30 years. He ...
(Date:10/31/2014)... October 31, 2014 In an effort to ... Dr. Majid Jamali announced he will soon offer orthodontics at ... the end of November. , To build upon the ... of New York has become known for, Dr. Jamali is ... from such top learning institutions as UCLA, Stanford and UCSF. ...
Breaking Medicine News(10 mins):Health News:This Thanksgiving or Christmas Family Gathering, Use The New App ListStuffFast to Start "The Conversation" With a Parent That Has No Plan For End-of-Life 2Health News:This Thanksgiving or Christmas Family Gathering, Use The New App ListStuffFast to Start "The Conversation" With a Parent That Has No Plan For End-of-Life 3Health News:Compression Gear--Is There a Better Alternative? 2Health News:Compression Gear--Is There a Better Alternative? 3Health News:Compression Gear--Is There a Better Alternative? 4Health News:Insomnia increases risk of motor vehicle deaths, other fatal injuries 2Health News:William Kasper, MD Garden City Ophthalmologist, Joins Medical Staff at North Shore Eye Care 2Health News:William Kasper, MD Garden City Ophthalmologist, Joins Medical Staff at North Shore Eye Care 3Health News:Oral & Maxillofacial Surgery of New York Adds Orthodontic Patient Services 2Health News:Oral & Maxillofacial Surgery of New York Adds Orthodontic Patient Services 3
(Date:10/31/2014)... -- AbbVie (NYSE: ABBV ) today announced ... 30, 2014. "Our third-quarter results ... double-digit growth from HUMIRA and several other key ... in the quarter excluding lipids," said Richard A. ... exceeded our outlook for the quarter and have ...
(Date:10/30/2014)... Oct. 30, 2014 WuXi PharmaTech (Cayman) Inc. (NYSE: ... and technology platform company serving the pharmaceutical, biotechnology, and ... and the United States ... in the Tel Aviv area ... promote WuXi,s broad platform of integrated R&D services to ...
(Date:10/30/2014)... -- The number of retail health clinics in ... to drug store chains, according to Kalorama Information.  In ... retail clinic growth had been at a standstill, but ... of retail clinics reached nearly 1,600 according to the ... and 2014 Consumer Survey Results .  More ...
Breaking Medicine Technology:AbbVie Reports Third-Quarter 2014 Financial Results 2AbbVie Reports Third-Quarter 2014 Financial Results 3AbbVie Reports Third-Quarter 2014 Financial Results 4AbbVie Reports Third-Quarter 2014 Financial Results 5AbbVie Reports Third-Quarter 2014 Financial Results 6AbbVie Reports Third-Quarter 2014 Financial Results 7AbbVie Reports Third-Quarter 2014 Financial Results 8AbbVie Reports Third-Quarter 2014 Financial Results 9AbbVie Reports Third-Quarter 2014 Financial Results 10AbbVie Reports Third-Quarter 2014 Financial Results 11AbbVie Reports Third-Quarter 2014 Financial Results 12AbbVie Reports Third-Quarter 2014 Financial Results 13AbbVie Reports Third-Quarter 2014 Financial Results 14AbbVie Reports Third-Quarter 2014 Financial Results 15AbbVie Reports Third-Quarter 2014 Financial Results 16AbbVie Reports Third-Quarter 2014 Financial Results 17AbbVie Reports Third-Quarter 2014 Financial Results 18AbbVie Reports Third-Quarter 2014 Financial Results 19AbbVie Reports Third-Quarter 2014 Financial Results 20AbbVie Reports Third-Quarter 2014 Financial Results 21AbbVie Reports Third-Quarter 2014 Financial Results 22AbbVie Reports Third-Quarter 2014 Financial Results 23AbbVie Reports Third-Quarter 2014 Financial Results 24WuXi AppTec Launches Representative Office in Israel, Forms Strategic Collaboration with Pontifax 2Report: Drugstore Chains Drive Retail Clinic Growth 2Report: Drugstore Chains Drive Retail Clinic Growth 3
Cached News: