HOME >> MEDICINE >> NEWS
Mechanism for neurodenegerative diseases linked to transport proteins

Hampering the transport of proteins within cells may underlie several adult-onset neurodegenerative diseases, such as Huntington's, ALS and Kennedy disease. Understanding how this cell transport is blocked in these diseases may offer targets for future therapy.

In a new study published online June 4 in Nature Neuroscience, researchers from the University of Illinois at Chicago College of Medicine showed how a chemical pathway that is obstructed in Kennedy disease interferes with a cellular distribution system called "fast axonal transport" that moves proteins from where they are synthesized to where they are needed in the cell.

This transport system is critical in neurons because these cells can be as much as three feet long, says Dr. Scott Brady, professor and head of anatomy and cell biology at UIC.

"A breakdown in fast axonal transport would selectively kill neurons because neurons are especially dependent on the transport system," Brady said.

Kennedy disease is also known as spinal and bulbar muscular atrophy, or SBMA. Like the better-known ALS and Huntington's, it is a rare but devastating disease, affecting one in 40,000 people, usually between the ages of 30 and 50. Huntington's strikes about four times as many.

Neurodegenerative diseases like SBMA are caused by the lengthening of part of a gene that encodes repetitions of the amino acid glutamine in the protein. Although different genes are affected, all of the polyglutamine-expansion or "polyQ" diseases are characterized by symptoms that begin in middle age and by the loss of certain types of neurons through a pattern in which the neuron's terminals die before the cell body. PolyQ genes are expressed in many types of cells, but only neurons are affected.

Earlier studies had linked specific neurodegenerative diseases to mutations in proteins involved in intracellular transport. This led researchers to wonder if the deranged polyQ proteins inhibit fast axonal t
'"/>

Contact: Jeanne Galatzer-Levy
jgala@uic.edu
312-996-1583
University of Illinois at Chicago
8-Jun-2006


Page: 1 2

Related medicine news :

1. Mechanism of hallucinogens effects discovered
2. Mechanism of black cohosh versus hot flashes revealed
3. Mechanism identified for promising neurological drug
4. Mechanism controlling DNA damage response has potential novel medical applications
5. A broader look at cardiac CTA images often finds diseases/disorders beyond the heart
6. Anemia and tropical diseases; Is pharmacogenomics ready for the clinic?
7. Green tea holds promise as new treatment for inflammatory skin diseases
8. Aging stem cells in mice may hold answers to diseases of the aged, Stanford study finds
9. Researchers develop criteria to detect bone mass deficiencies in children with chronic diseases
10. Scripps Research awarded $17 million for adult stem cell use to treat eye diseases
11. New therapeutic targets for neurodegenerative diseases

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/15/2019)... , ... August 15, 2019 , ... ... to pathology residents who have been directly affected by the closure of Hahnemann ... of donations gathered during the campaign, the ASCP Foundation will be making hardship ...
(Date:8/14/2019)... ... August 14, 2019 , ... Inc. magazine today revealed that ... Inc. 5000 list, the most prestigious ranking of the nation’s fastest-growing private companies. With ... companies and #153 in the Health sector. The list represents a unique look at ...
(Date:8/14/2019)... ... August 13, 2019 , ... In a recent Trivedi ... of doubt in your belief systems. , “Doubt can obliterate your old beliefs,” said ... path to examining them to expand your understanding and your awareness. Trust that the ...
(Date:8/12/2019)... ... August 12, 2019 , ... Cryotherapy has recently been the target of ... Raiders. However, the cause of Brown’s injury was not due to cryotherapy, but due ... Numerous NFL teams, such as the Dallas Cowboys, the Washington Redskins, the Denver Broncos ...
(Date:8/9/2019)... ... 2019 , ... The Los Angeles employment law lawyers at Blumenthal Nordrehaug ... Natural Food Markets, Inc., failed to provide their California employees with meal and rest ... action lawsuit, Case No. 19STCV26728, is currently pending in the Los Angeles County Superior ...
Breaking Medicine News(10 mins):
(Date:8/17/2019)... ... August 17, 2019 , ... ... 5000 , Foster Crown, LLC Ranks No. 2502 on the 2019 Inc. 5000 ... Foster Crown, LLC, the boutique physician recruitment firm is No. 2502 on its ...
(Date:8/16/2019)... , ... August 16, 2019 , ... ... service, Eye Movement Desensitization and Reprocessing therapy (EMDR). This therapeutic technique aims to ... evidence-based practice used for post-traumatic stress disorder (PTSD), depression, chronic pain, anxiety, and ...
(Date:8/16/2019)... MILWAUKEE (PRWEB) , ... August 16, 2019 , ... ... is pleased to welcome South Bend Emergency Physicians (SBEP) of Indiana as a ... services to Memorial Hospital of South Bend. , SBEP sought out the ...
Breaking Medicine Technology:
Cached News: