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Medication reduces risk of heart irregularities after cardiac surgery

Use of the medication amiodarone is associated with one-half the incidence of atrial tachyarrhythmias (rapid, abnormal heart beat) following cardiac surgery, according to a study in the December 28 issue of JAMA.

Atrial tachyarrhythmias, usually atrial fibrillation or atrial flutter, often occur immediately after cardiac surgery and are the most common postoperative complication, according to background information in the article. The incidence of sustained atrial tachyarrhythmias after coronary artery bypass graft (CABG) surgery is approximately 30 percent; after valve surgery, approximately 40 percent; and after combined CABG and valve replacement/repair surgery, approximately 50 percent. The consequences of these atrial tachyarrhythmias include discomfort or anxiety, stroke, exposure to the risks of tachyarrhythmia treatments, prolongation of hospital stay, and increased health care costs. Atrial tachyarrhythmias have recently been reported to increase hospital stay after cardiac surgery by an average of 1.4 days at an additional cost of $6,356 per patient. Substantial effort has been invested in finding an effective, safe, and widely applicable preventive treatment for atrial tachyarrhythmia occurring after cardiac surgery. Previous trials of amiodarone were relatively small and yielded conflicting results.

L. Brent Mitchell, M.D., and colleagues from the University of Calgary, Canada, conducted the Prophylactic Amiodarone for the Prevention of Arrhythmias that Begin Early After Revascularization, Valve Replacement, or Repair (PAPABEAR) trial to test the hypothesis that amiodarone is an effective, well-tolerated, and safe therapy for prevention of atrial tachyarrhythmias after cardiac surgery. The placebo-controlled, randomized trial compared younger patients (less than 65 years) with older patients (65 years or older), patients undergoing CABG surgery compared with patients undergoing cardiac valve surgery or combined CABG and valve replacemen
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Contact: Colleen Donahue
403-210-8522
JAMA and Archives Journals
27-Dec-2005


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