HOME >> MEDICINE >> NEWS
Metabolic study in mice could lead to 'good cholesterol' boosters

Researchers have identified a new player in the control of so-called good cholesterol that circulates in the bloodstream and reduces heart attack risk, according to a report in the August issue of Cell Metabolism, a publication of Cell Press. Should the metabolic pathway uncovered in mice operate similarly in humans, the new discovery could point the way to therapies that protect against heart disease by boosting concentrations of the beneficial high-density lipoprotein cholesterol (HDL-C).

By and large, the medicines now available lower levels of the bad low-density lipoprotein cholesterol [LDL-C], said Weijun Jin of the University of Pennsylvania School of Medicine. There is a great need for methods to raise good cholesterol levels. Our findings suggest there may be multiple places to interrupt the metabolism of HDL-C.

LDL-C can build up in blood vessel walls, increasing the risk of heart disease or stroke. By contrast, HDL-C tends to carry cholesterol away from the arteries to the livera process known as reverse cholesterol transportwhere it is broken down and then eliminated from the body.

Existing LDL-C-lowering drugs such as statins can reduce the risk of heart attack by 20 to 35 percent, Jin said. However, treatment methods that would simultaneously lower bad cholesterol and increase good cholesterol have the potential to work even better. Indeed, researchers believe that increasing HDL-C while lowering LDL-C might cut heart attack risk by as much as 70 percent, he explained.

In the current study, the researchers found that treatments that partially block the activity of liver enzymes called proprotein convertases decreased plasma HDL-C levels in mice. They showed that the metabolic effect of the proprotein convertases depended on yet another factor, an enzyme called endothelial lipase (EL), which breaks down HDL-C. Proprotein convertases normally reduce EL function, they reported. Thus, the loss of proprotein conver
'"/>

Contact: Erin Doonan
edoonan@cell.com
617-397-2802
Cell Press
7-Aug-2007


Page: 1 2

Related medicine news :

1. Metabolic syndrome points to heart health
2. Metabolic disorder not well-suited for inclusion in newborn screening programs
3. Metabolic syndrome significantly boosts risk of heart failure in middle age
4. Metabolic acidosis associated with an increased mortality rate
5. Metabolic syndrome identified as risk factor for kidney-pancreas transplant patients
6. Metabolic syndrome prevalent in heart attack patients
7. Metabolic side effects of antipsychotics are known, but rarely monitored
8. Childhood obesity indicates greater risk of school absenteeism, Penn study reveals
9. Penn study finds pro-death proteins required to regulate healthy immune function
10. New study shows promise in reducing surgical risks associated with surgical bleeding
11. New study counts the economic cost of persistent pain in Australia

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/26/2017)... ... September 26, 2017 , ... Ron Norman, CEO of ... use the Law of Large Numbers in favor of senior, upper-level executive job candidates ... casinos, have long understood the Law of Large Numbers as a way of protecting ...
(Date:9/26/2017)... ... September 26, 2017 , ... CGL Electronic Security Inc., an ... its new umbrella, CGL Technologies, LLC. , The new CGL Technologies, LLC office is ... and Jon McCormack, both of whom have creative business development methods, who are responsive ...
(Date:9/26/2017)... Galloway, N.J. (PRWEB) , ... September 26, 2017 ... ... mocktail at the shore, the John R. Elliott HERO Campaign for Designated Drivers ... Hotel & Golf Club. , Thirty-one local bars and restaurants took on the ...
(Date:9/26/2017)... (PRWEB) , ... September 26, 2017 , ... Founded as ... decades growing into an innovative leader in special education. In 2018, Glenholme will ... , Glenholme, formerly a world renowned horse farm for Hackney show ponies, was generously ...
(Date:9/26/2017)... ... September 26, 2017 , ... The 2017 American Academy of Cosmetic Surgery ... Fat,” revealed not only the latest about cosmetic procedures to remove and replace fat, ... cosmetic medicine. , “Fat really is magical, especially when it comes to the cosmetic ...
Breaking Medicine News(10 mins):
(Date:9/5/2017)... Sapheneia and Scannerside received FDA 510(k) clearance ... a third-party Vendor neutral CT product that makes it ... with current MITA standards. ... is specifically designed to provide CT operators, prior to ... over a predefined threshold. Scannerside Dose Check is intended ...
(Date:9/5/2017)... , Sept. 5, 2017  Getinge, a leading ... a vibrant charitable donation program -- "Color for ... congenital heart defect research by The Children,s Heart ... the general public are encouraged to download a ... the completed artwork to the gallery on the ...
(Date:9/5/2017)... Oramed Pharmaceuticals Inc. (NASDAQ: ORMP ) (TASE: ... on the development of oral drug delivery systems, announced ... the U.S. Food and Drug Administration (FDA) regarding ORMD-0801, ... At the meeting, the FDA gave ... ORMD-0801, would be a Biologics License Application (BLA).  Such ...
Breaking Medicine Technology:
Cached News: