HOME >> MEDICINE >> NEWS
Misdosing common for powerful anti-clotting drugs

Because of inaccuracies in prescribing, 42 percent of patients rushed to emergency rooms with symptoms of a heart attack received doses of powerful drugs intended stop clotting in coronary arteries outside of the recommended range, a new analysis by Duke Clinical Research Institute (DCRI) cardiologists has found.

While numerous clinical trials have proven that these drugs can save lives, correct dosing is crucial, the researchers said, since the therapeutic window is narrow. Too much of the drug can lead to bleeding episodes, while too little may be ineffective at stopping the clotting process.

The Duke researchers believe that when evaluating these patients in emergency rooms, physicians should spend a little more time clarifying information such as weight and kidney function which are necessary for accurate dosing. The researchers also hope that the results of their analysis provide concrete steps to improve safety thereby increasing physician confidence in using these drugs on high risk patients, who have the most to gain.

"These drugs are clearly beneficial, and when dosed correctly, are also safe," said Duke cardiologist Karen Alexander, M.D., lead investigator of the study published Dec. 28, 2005, in the Journal of the American Medical Association.

The drugs in question unfractionated heparin (UFH), low-molecular-weight heparin (LMWH) and glycoprotein IIb/IIIa inhibitors work by either preventing the aggregation of platelets in coronary arteries or interfering with the formation of blood clots. The drugs are typically given within the first 24 hours of heart attack symptoms, and it is not uncommon for patients to receive combinations of these drugs during their hospital stay. Doses are determined by patient-specific data incorporated into standard prescribing algorithms.

"Our analysis, which includes patients treated in all types of hospitals across the country shows that dosing errors occur more often in vulnerabl
'"/>

Contact: Richard Merritt
Merri006@mc.duke.edu
919-684-4148
Duke University Medical Center
27-Dec-2005


Page: 1 2 3

Related medicine news :

1. Refusal of medical and surgical interventions common among chronically ill elderly
2. Needle-stick injuries are common but unreported by surgeons in training
3. Sleep-related breathing disorder common among aggressive, bullying schoolchildren
4. Nearly half of children in Kenya with common type of severe malaria affected neurologically
5. Scientists identify cells responsible for relapse after treatment in common childhood cancer
6. Infection detectives use disease fingerprints to track common infections in children
7. Anxiety disorders surprisingly common yet often untreated
8. Mental illnesses appear common among veterans returning from Iraq and Afghanistan
9. Sleep apnea common, but undiagnosed, among pacemaker patients
10. Use of common pain relievers associated with increased risk of blood pressure in men
11. Updated rates of common US neurological disorders

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/5/2016)... ... May 05, 2016 , ... United Collection Bureau, Inc. (UCB) announces Sarah Clark ... 15 years of experience within the healthcare revenue cycle industry. With a primary focus ... of Patient Financial Services at Spectrum Health. While at Spectrum Health, Clark helped Spectrum ...
(Date:5/5/2016)... ... 05, 2016 , ... T.E.N., a technology and information security ... at the 2016 ISE® Central Executive Forum and Awards Gala at the Sheraton ... Officer of HMS, was selected as the Information Security Executive® of the Year ...
(Date:5/5/2016)... ... May 05, 2016 , ... ACLS Certification Institute, a ... new referral program, giving participants incentive for spreading the word about the Institute’s ... know many professionals share resources with their friends and colleagues,” said Vonda Andrews, ...
(Date:5/5/2016)... ... May 05, 2016 , ... ... Medical Society of Northern Virginia, Announces DoctorsTelemed?, A telehealth solution powered ... of Northern Virginia (MSNVA) launches DoctorsTelemed?, a telemedicine solution that uses CloudVisit’s ...
(Date:5/5/2016)... ... May 05, 2016 , ... In the midst of making ... the most important arrangement — planning a safe way of getting home after the ... drinks. Unfortunately, these celebrations often lead to drunk drivers on the roads who become ...
Breaking Medicine News(10 mins):
(Date:5/5/2016)... , May 5, 2016  Diagnostic imaging has ... due to concerns that these tests cause health care costs ... to imaging, as well as the adoption of ... of medical peripherals that help health care providers cut costs, ...  advanced medical imaging is a renowned authorized reseller of ...
(Date:5/5/2016)... , May 5, 2016 Research ... for PET Imaging in the USA"  report to their ... provides information on the current Positron Emission Tomography (PET) ... USA market. Along with the current known ... USA , the report also contains a ...
(Date:5/5/2016)... May 5, 2016 Research and Markets has ... in Top 5 EU Markets"  report to their offering.  ,     ... provides information on the current Positron Emission Tomography (PET) scanner ... (T5 EU), which includes France , ... Spain and the United Kingdom ...
Breaking Medicine Technology:
Cached News: