HOME >> MEDICINE >> NEWS
Molecular change occurring during brain tumor progression also evident in breast cancer

LOS ANGELES (May 3, 2005) -- A molecular change that takes place during the progression of malignant brain tumors also occurs in breast cancer, according to a study conducted at Cedars-Sinai's Maxine Dunitz Neurosurgical Institute. The shift appears to be part of a process that enables tumors to develop the new blood vessels they need to grow rapidly, migrate and invade other tissue.

Although the switch is evident even in an early stage of breast cancer when cells are proliferating but not infiltrating normal tissue, it becomes more pronounced as the cancer progresses to the invasive stage. Therefore, the genes involved and the proteins they produce may become markers that physicians can use to determine disease progression and patient prognosis. They also may become targets for new therapies.

The switch affects proteins called laminins, which are components of the "basement membrane" of blood vessels, a thin mesh-like structure beneath the cells of the blood vessel surface (epithelium). Although the surface cells and the basement membrane are distinct entities, they affect each other through biochemical interactions. In fact, the cells actually influence the composition of the basement membrane, and the membrane, in addition to serving as a scaffold for cell attachment, regulates cell behavior, proliferation and migration.

The laminin molecule is composed of three chains -- designated alpha (), beta (]) and gamma (^) -- that are linked together in various combinations to form 15 known isoforms or types of laminin. Each isoform has distinct characteristics and functions. Isoforms are known to change in normal tissues at various stages of development but they also have been found to shift in the presence of several invasive cancers. This shift coincides with blood vessel changes that encourage tumor growth and metastasis.

Over the past several years, Cedars-Sinai researchers published several articles related to their findings t
'"/>

Contact: Sandy Van
sandy@prpacific.com
1-800-880-2397
Cedars-Sinai Medical Center
4-May-2005


Page: 1 2 3

Related medicine news :

1. Elsevier launches Molecular Oncology
2. Molecular marker may help identify pancreatic cancer, and possibly predict survival time
3. Molecular differences between early and advanced melanomas could provide new drug targets
4. Molecular structure reveals how botulinum toxin attaches to nerve cells
5. Molecular medicine comes to the rescue
6. Molecular switch may turn off immune cells that target HIV
7. Molecular imaging may lead to earlier diagnosis of childhood respiratory virus
8. The Molecular Profiling Institute, Inc. and IBM advance technology
9. Molecular Profiling Institute secures $7.5 million in Series B funding
10. Molecular studies in cancer of the colon
11. Molecular ballet unravels, links proteins so cell can direct own movement

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/8/2019)... ... December 08, 2019 , ... Intelligent.com, a trusted resource for ... Degree Programs for 2020. The comprehensive research guide is based on an assessment ... based on curriculum quality, graduation rate, reputation, and post-graduate employment. , The ...
(Date:12/6/2019)... ... 2019 , ... Connecticut is home to a growing healthcare ... On December 12th, Hartford Business Journal will recognize eight individuals and organizations who ... the Hartford Marriott. , “We are fortunate to have so many great providers ...
(Date:12/6/2019)... ... December 06, 2019 , ... COMPLIANCY GROUP ... for the Wyoming Medical Society. Compliancy Group is dedicated to educating and assisting ... obligation to adhere to the standards set forth by the Health Insurance Portability ...
(Date:12/5/2019)... CHESTERFIELD, Mo. (PRWEB) , ... December 05, 2019 ... ... States is offering new, high resolution ultrasound (HRUS) technology to help their patients ... surgeon in Chesterfield, MO, is participating in this study and reporting on his ...
(Date:12/5/2019)... ... December 05, 2019 , ... It’s been an impactful year ... help people embrace, achieve, and maintain a healthy lifestyle to giving generously to ... our mission of impacting world health, so it’s gratifying to look back on ...
Breaking Medicine News(10 mins):
(Date:12/4/2019)... WASHINGTON, Pa. (PRWEB) , ... December 04, 2019 ... ... solutions empower physicians to better manage their COPD patient’s symptoms, joined forces nearly ... Tulsa’s COPD patients immediate access to in-person care at times when the attention ...
(Date:12/2/2019)... Kan. (PRWEB) , ... December 02, 2019 , ... ... XX, a nutritional supplement produced by Native Remedies aimed at supporting Women’s Fertility ... Unfortunately, Mother Nature makes conception harder for some women than for others. Factors ...
(Date:11/30/2019)... Fla. (PRWEB) , ... November 29, 2019 , ... ACC ... This long awaited expansion was due to Amazon’s incredibly large purchase of ... had been delayed by Mercedes, they’ve recently received word on vehicle availability and are ...
Breaking Medicine Technology:
Cached News: