HOME >> MEDICINE >> NEWS
Molecular imaging may lead to earlier diagnosis of childhood respiratory virus

Scientists have used a powerful molecular imaging technique to see inside living cells infected with the most pervasive and potentially fatal childhood respiratory virus known to medicine -- respiratory syncytial virus (RSV). The technique is yielding insight on viruses such as RSV, human influenza, hepatitis C, West Nile virus and severe acute respiratory syndrome (SARS) -- that replicate with the help of proteins encoded by ribonucleic acid (RNA) inside the cell. Ultimately, the research could to lead to early and rapid detection of viral infection and the design of new antiviral drugs.

Scientists and engineers at the Georgia Institute of Technology and the University of Georgia are studying bovine and human RSV with molecular-scale probes called molecular beacons that are engineered oligonucleotides (short sequences of RNA or DNA) shaped like a hairpin with a fluorescent dye molecule on one end and a quencher molecule on the other end. They are designed to fluoresce only when they bind to a complementary target in this case, RSV genomic RNA.

"For the first time, we were able to visualize an important part of the RSV virus -- its genome -- in live, infected cells," said Phil Santangelo, a research engineer in the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University. "Our molecular beacons attach to the virus and glow inside infected cells as the virus grows, replicates and infects other cells. We can now see that happen in real time in cultures in the lab.

"That's very different from how scientists have studied viruses in past; they've looked at viruses in fixed (or preserved) cells," he added. ". Within the first week of studying human RSV in living cells, I learned something new because I was looking at it live."

Molecular beacons were originally developed at the Public Health Research Institute in New Jersey in the late 1990s. They were initially used for in vitro assays o
'"/>

Contact: Jane Sanders
jsanders@gatech.edu
404-894-2214
Georgia Institute of Technology Research News
18-Apr-2006


Page: 1 2 3

Related medicine news :

1. Elsevier launches Molecular Oncology
2. Molecular marker may help identify pancreatic cancer, and possibly predict survival time
3. Molecular differences between early and advanced melanomas could provide new drug targets
4. Molecular structure reveals how botulinum toxin attaches to nerve cells
5. Molecular medicine comes to the rescue
6. Molecular switch may turn off immune cells that target HIV
7. The Molecular Profiling Institute, Inc. and IBM advance technology
8. Molecular Profiling Institute secures $7.5 million in Series B funding
9. Molecular studies in cancer of the colon
10. Molecular ballet unravels, links proteins so cell can direct own movement
11. Molecular testing in patients with rare cancer predicts response to Gleevec

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/3/2020)... ... August 03, 2020 , ... WorkBook6 – a Tempe, Arizona-based ... The site provides a simple and efficient way for Americans over the age ... as an important expansion for the insurance marketing ecosystem, and a critical service ...
(Date:7/31/2020)... ... July 31, 2020 , ... Leaders of the Operation ... site in Savannah, GA. Visitors included Moncef Slaoui, chief advisor, and General Gustave ... announced the OWS program to accelerate the development, manufacturing, and distribution of COVID-19 ...
(Date:7/31/2020)... ... July 31, 2020 , ... National Association of Chain Drug ... regarding the nation’s ongoing preparations for the eventual deployment of COVID-19 vaccines: , ... effective and essential component of vaccine deployment. They will need to be part ...
(Date:7/22/2020)... ... July 22, 2020 , ... ... Lives Matter movement, the world has changed, and there’s no going back. In ... While coping mechanisms help us temporarily manage emotional struggles, healing is the approach ...
(Date:7/22/2020)... Okla. (PRWEB) , ... July 22, 2020 , ... ... today announced the launch of its new Data Curation as a Service (DCaaS) ... use case modules focus on specific clinical data curation parameters and are custom ...
Breaking Medicine News(10 mins):
(Date:7/22/2020)... ... , ... Local animal nutrition expert, Dr. Anoosh Rakhshandeh, and his wife, Dr. ... supplies company – Pet Wants Lubbock. , Pet Wants’ specially-crafted, private-label pet food formulas ... for a complete and balanced diet in every bite. Pet Wants Lubbock has multiple ...
(Date:7/18/2020)... ... , ... A Perspective essay published in Psychosomatics: ... among psychiatrists and other clinicians can affect patient-clinician communication and diminish the quality ... authored by researchers at The Fenway Institute and Massachusetts General Hospital and adds ...
(Date:7/10/2020)... (PRWEB) , ... July 10, 2020 , ... ... developed new guidance for HIPAA Compliance for Business Associates. Business associates create, receive, ... entity clients. As such, business associates are required to be HIPAA compliant, ensuring ...
Breaking Medicine Technology:
Cached News: