HOME >> MEDICINE >> NEWS
Molecular marker may help identify pancreatic cancer, and possibly predict survival time

Preliminary research suggests that the expression pattern of microRNA (a short RNA molecule) may be useful in differentiating between chronic pancreatitis and pancreatic cancer and may be able to distinguish long and short term survival time for patients with pancreatic cancer, according to an article in the May 2 issue of JAMA.

Pancreatic cancer is a lethal disease, with the annual deaths nearly equaling the incidence of 33,000 in the United States, according to background information in the article. In humans, aberrant expression of miRNAs contributes to carcinogenesis by promoting the expression of proto-oncogenes (a normal gene that has the potential to become an oncogene [a gene that can cause a cell to become malignant]) or by inhibiting the expression of tumor suppressor genes. MicroRNAs (miRNAs) are small noncoding RNAs (ribonucleic acids; nucleic acids are present in all living cells). The role of miRNAs in ductal adenocarcinoma (malignant tumor) of the pancreas is not clear.

Mark Bloomston, M.D., of Ohio State University, Columbus, Ohio, and colleagues conducted a series of experiments to identify the pattern of miRNA expression in pancreatic adenocarcinoma to attempt to differentiate pancreatic cancer from benign pancreatic tissue and any differences in survival associated with certain miRNA expression. Study specimens were obtained at a National Cancer Institute-designated comprehensive cancer center from patients with ductal adenocarcinoma of the pancreas (n = 65) or chronic pancreatitis (n = 42) (January 2000-December 2005). RNA was harvested from resected pancreatic cancers and benign adjacent pancreatic tissue as well as from chronic pancreatitis specimens and subsequent miRNA was analyzed to identify associations with certain tissue types and prognosis.

"We have identified-we believe for the first time-a global expression pattern of miRNAs that can differentiate ductal adenocarcinomas of the pancreas from normal panc
'"/>

Contact: David Crawford
614-293-3737
JAMA and Archives Journals
1-May-2007


Page: 1 2 3

Related medicine news :

1. Elsevier launches Molecular Oncology
2. Molecular differences between early and advanced melanomas could provide new drug targets
3. Molecular structure reveals how botulinum toxin attaches to nerve cells
4. Molecular medicine comes to the rescue
5. Molecular switch may turn off immune cells that target HIV
6. Molecular imaging may lead to earlier diagnosis of childhood respiratory virus
7. The Molecular Profiling Institute, Inc. and IBM advance technology
8. Molecular Profiling Institute secures $7.5 million in Series B funding
9. Molecular studies in cancer of the colon
10. Molecular ballet unravels, links proteins so cell can direct own movement
11. Molecular testing in patients with rare cancer predicts response to Gleevec

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/19/2019)... ... April 19, 2019 , ... ... a reputation for building strategic partnerships that deliver innovative solutions to its ... team expansion to deliver healthcare administrative services and high-performance network development throughout ...
(Date:4/19/2019)... ... , ... Edens Garden launches 7 new, natural deodorant aromas as ... pure essential oils and non-toxic ingredients to keep you fresh all day. Finally, a ... release all-natural but baking soda- and aluminum-free, making this deodorant a must for those ...
(Date:4/18/2019)... and DANVERS, Mass. (PRWEB) , ... April 18, ... ... radiotherapy and proton therapy, with the ability to deliver targeted radiation to cancer ... the nuclear reactor in traditional BNCT research platforms. Engineered from the ground up ...
(Date:4/18/2019)... ... April 18, 2019 , ... Dr. Matt Nejad is ... a full menu of cosmetic and general dental care services. Dr. Nejad is ... which relies on minimally-invasive techniques in restorative dentistry. Biomimetic dentistry uses a more ...
(Date:4/18/2019)... ... April 18, 2019 , ... ... first ever Cannabis Industry Report . The study—which considers consumers’ perceptions of, ... with retail and manufacturing, offering insight into what kinds of products consumers want ...
Breaking Medicine News(10 mins):
(Date:4/19/2019)... ... April 18, 2019 , ... Janice F. Whaley has a vision. A vision ... chance at life. Ms. Whaley has focused her entire career on the mission of ... organ and tissue donation for transplantation. , There is a sad reality for the individuals ...
(Date:4/18/2019)... FORT LAUDERDALE, Fla. (PRWEB) , ... April 18, ... ... program for the workers' compensation industry, today announced it has been invited to ... Annual Conference & Exhibition, which will be coming to Boston April 28th ...
(Date:4/18/2019)... ... April 18, 2019 , ... ... Association (FMA). The FMA is one of the country’s premier professional associations dedicated ... Medicine in Florida. The FMA currently represents over 25,000 members on issues of ...
Breaking Medicine Technology:
Cached News: