HOME >> MEDICINE >> NEWS
Monoclonal antibody cures West Nile virus-infected mice

St. Louis, April 24, 2005 -- A newly developed monoclonal antibody can cure mice infected with the West Nile virus, scientists at Washington University School of Medicine in St. Louis report. If further studies confirm the effectiveness and safety of the antibody, it could become one of the first monoclonal antibodies used as a treatment for an infectious disease.

In a strain of mice that normally only has about a 10 percent survival rate after West Nile infection, scientists found that single doses of the antibodies given soon after infection could boost survival rates to 90 percent or higher.

"To our knowledge, these experiments are the first successful demonstration of the use of a humanized antibody as a post-exposure therapy against a viral disease," says senior investigator Michael Diamond, M.D., Ph.D., assistant professor of molecular microbiology, pathology and immunology and of medicine. "They also suggest antibody-based therapeutics may have a broader utility against other infectious diseases." Diamond points out that Macrogenics Inc., of Rockville, Md., a company that contributed to the study and licensed the antibody from Washington University, must complete other preliminary studies before the antibody can be tested in humans. But he and his colleagues are excited both by the apparent potency of the antibody and its potential to help them explore new possibilities for treating related viruses that are more prolific causes of human disease and death.

"We could give a single dose of this antibody to mice as long as five days after infection, when West Nile virus had entered the brain, and it could still cure them," says Diamond. "It also completely protected against death from the disease."

Diamond and his colleagues will report their results in the May issue of Nature Medicine.

In 2004, West Nile virus reportedly caused 2,470 infections and 88 deaths in the United States. The mosquito-borne virus, first isolated in Africa
'"/>

Contact: Michael C. Purdy
purdym@wustl.edu
314-286-0122
Washington University School of Medicine
24-Apr-2005


Page: 1 2 3 4

Related medicine news :

1. Monoclonal antibody reduces exacerbations in asthmatics
2. Buckyballs boost antibodys chemotherapy payload
3. Combination therapy with a monocloncal antibody and a vaccine leads to tumor rejection
4. Clinical trial confirms novel EGFR antibody targets tumors but not normal tissues
5. New antibody profiling technique to test for lung cancer
6. Radiation therapy combo cures prostate cancer long-term
7. University of Rochester spin-off secures $2 million in funding
8. Medical College of Wisconsin secures key contract from US HRSA
9. Summer update: Melanoma research progress suggests optimism for future cures
10. Procedure cures some diabetic mice, but not in the way previously reported
11. No evidence that hangover cures work

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/31/2020)... ... August 31, 2020 , ... ... management solution for chiropractors, announced today the launch of its integrated, HIPAA compliant, ... start running their virtual practice in under 90 seconds. , According to ...
(Date:8/31/2020)... IRVINE, Calif. (PRWEB) , ... August 31, 2020 ... ... providers of business support services to dental groups in the United States, today ... serving the community of Beaumont, CA. , Patients will enjoy convenient hours, ...
(Date:8/31/2020)... ... 31, 2020 , ... A Cure for Covid-19 “PTS” with Mediation & Hypnosis , At ... a state of panic, experiencing deep anxiety, immense stress, and right now are needing serious ... when most people on the planet are experiencing a great degree of emotional discomfort, be ...
(Date:8/31/2020)... PASADENA, Calif. (PRWEB) , ... August 31, 2020 ... ... and leadership experience working, both directly with persons with autism and other developmental ... clinical expertise includes early intervention, parent education, adolescents with autism, school consultation, and ...
(Date:8/29/2020)... ... ... When professor and author Randy Pausch was diagnosed with pancreatic cancer, he accepted ... melancholic, however, he put together a final lecture in Carnegie Hall in which he ... situation and turned it into something that inspired millions of people worldwide. This inclination ...
Breaking Medicine News(10 mins):
(Date:8/31/2020)... ... August 31, 2020 , ... Continuing on its ... broad-spectrum sanitization, disinfection and deodorization provider - is proud to announce it has ... services for businesses and residents throughout the area. , Germinator provides a 100% ...
(Date:8/28/2020)... ANTONIO (PRWEB) , ... August 28, 2020 , ... ... and operator of primary care medical centers in Florida and San Antonio is ... for its South Texas medical centers. , In this capacity he will serve ...
(Date:8/28/2020)... ... 2020 , ... Dr. Raheleh Sarbaziha has been reimagining the ... Armed with her qualifications from Ross University School of Medicine and the University ... body with the nation and world. With a fellowship in Integrative Medicine Dr. ...
Breaking Medicine Technology:
Cached News: