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Monoclonal antibody cures West Nile virus-infected mice

allow the new West Nile antibody to block viral infection.

Diamond and Fremont are looking for other areas of the West Nile virus E protein that antibodies can bind to and neutralize the virus. Diamond is also using the yeast screening system to epitope map the sites on the dengue fever virus where antibodies can bind and inadvertently enhance infection instead of fighting it.

"We don't really understand on a molecular level what's happening in these cases, which are called enhancing antibodies," Diamond explains. "Epitope mapping may help us better understand this potentially dangerous interaction."

Researchers at Macrogenics were coauthors on this paper, and Diamond now serves as a consultant for the company.


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Contact: Michael C. Purdy
purdym@wustl.edu
314-286-0122
Washington University School of Medicine
24-Apr-2005


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