HOME >> MEDICINE >> NEWS
More insight into Alzheimer's disease with Stanford discovery of possible cause

STANFORD, Calif. - A peacekeeper in the body's defenses against infection may hold the key to understanding - and eventually treating - Alzheimer's disease. Researchers at the Stanford University School of Medicine discovered that when a molecule responsible for dialing down the immune system malfunctions in the brain cells of mice, the rodents develop symptoms of the degenerative brain disease.

The finding, published in the November issue of the Journal of Clinical Investigation, offers researchers an insight into how humans may develop Alzheimer's, said the study's senior author Tony Wyss-Coray, PhD, associate professor of neurology and a researcher at the Veterans Affairs Palo Alto Health Care System.

Alzheimer's disease is characterized by an excessive buildup of proteins into plaques and tangles of cellular gunk that are likely to cause brain cells to die and lose their connections to other neurons. But for the most part, scientists do not understand the underlying biological problems behind Alzheimer's, making it difficult for doctors to treat, let alone cure.

"We don't have a treatment that alters the course of the disease," said Wyss-Coray.

Wyss-Coray and Ina Tesseur, PhD, an instructor in the Department of Neurology, examined thin slices of the brains of Alzheimer's patients who had died, and discovered abnormally low levels of a molecule involved in controlling the body's response to infection. That molecule allows the brain to detect and respond to TGF-beta, or transforming growth factor, a protein teeming through our bodies, involved in fighting infection, stopping cancer and perhaps keeping brain cells alive.

No other researchers had seen this change before, so Tesseur and Wyss-Coray set out to investigate whether it had some connection to Alzheimer's disease. They hypothesized that by protecting neurons, TGF-beta may help prevent A
'"/>

Contact: Rosanne Spector
manishma@stanford.edu
650-725-5374
Stanford University Medical Center
20-Nov-2006


Page: 1 2 3

Related medicine news :

1. Sports concussion research using fMRI provides insight for safe return-to-play decisions
2. Better insight into brain anatomical structures
3. New insights into chronic inflammation and atherosclerosis
4. New insights into autoimmunity and depression
5. NIAID media availability: Examining genetic variability of malaria parasite offers insight
6. Functional brain imaging insights from UC San Diego grad student
7. Sticky proteins provide new insight into drug action
8. Laser probe of a brain pigments anatomy may offer insight into Parkinsons disease
9. New insights into the impact of pregnancy on inflammatory arthritis
10. Amnesiac study offers insights into how working memory works
11. Brain study yields insight into machinery of prejudice

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/15/2020)... , ... February 14, 2020 , ... Sister companies, Special ... - “BIG MONEY IN ABA”. The series explores the challenges, risks, and opportunities ... in the series on March 25, 2020 at: https://bit.ly/2OU6lxg , Since ...
(Date:2/14/2020)... ... February 14, 2020 , ... ScripHessco has announced the release ... guide breaks down the benefits of chiropractic care during pregnancy and how to ... is quite beneficial to the mother’s health. Seeing a chiropractor during pregnancy leads ...
(Date:2/14/2020)... ... February 14, 2020 , ... Cloudticity announced today ... the company’s support for healthcare organizations using Amazon Web Services (AWS). , “Our ... or experience to do so,” explained Cloudticity Founder & CEO, Gerry Miller. “In ...
(Date:2/13/2020)... ... February 13, 2020 , ... The Root Cause ... achieving health equity for all Americans will unveil its new Status of Health ... at the National Press Club. , The event will feature a presentation and ...
(Date:2/13/2020)... ... February 13, 2020 , ... ... Northern Virginia: Arlington, Dulles-Aldie, Fair Oaks, Fairfax, Fredericksburg, Leesburg, and Woodbridge, as well ... and Virginia-based fertility specialists have been named as Top Docs for Infertility by ...
Breaking Medicine News(10 mins):
(Date:2/19/2020)... ... February 19, 2020 , ... Drs. Mario Canal and Ben Calem will ... at The Mansion in Voorhees. The course features guest speaker, Dr. Amanda Seay, and ... implants, including All-on-4® full mouth dental implants, are a major focus ...
(Date:2/19/2020)... ... February 19, 2020 , ... Global Healthcare Exchange, ... the release of its annual GHX “Best 50” supply chains in ... for their ability to demonstrate improved operational performance and drive down costs through ...
(Date:2/15/2020)... Fla. (PRWEB) , ... February 14, 2020 , ... ... has established an "oral-systemic” link between the organisms that cause inflammatory gum disease ... from Tampa-based ProBiora Health?? , offers new tools in the fight against ...
Breaking Medicine Technology:
Cached News: