HOME >> MEDICINE >> NEWS
More insight into Alzheimer's disease with Stanford discovery of possible cause

STANFORD, Calif. - A peacekeeper in the body's defenses against infection may hold the key to understanding - and eventually treating - Alzheimer's disease. Researchers at the Stanford University School of Medicine discovered that when a molecule responsible for dialing down the immune system malfunctions in the brain cells of mice, the rodents develop symptoms of the degenerative brain disease.

The finding, published in the November issue of the Journal of Clinical Investigation, offers researchers an insight into how humans may develop Alzheimer's, said the study's senior author Tony Wyss-Coray, PhD, associate professor of neurology and a researcher at the Veterans Affairs Palo Alto Health Care System.

Alzheimer's disease is characterized by an excessive buildup of proteins into plaques and tangles of cellular gunk that are likely to cause brain cells to die and lose their connections to other neurons. But for the most part, scientists do not understand the underlying biological problems behind Alzheimer's, making it difficult for doctors to treat, let alone cure.

"We don't have a treatment that alters the course of the disease," said Wyss-Coray.

Wyss-Coray and Ina Tesseur, PhD, an instructor in the Department of Neurology, examined thin slices of the brains of Alzheimer's patients who had died, and discovered abnormally low levels of a molecule involved in controlling the body's response to infection. That molecule allows the brain to detect and respond to TGF-beta, or transforming growth factor, a protein teeming through our bodies, involved in fighting infection, stopping cancer and perhaps keeping brain cells alive.

No other researchers had seen this change before, so Tesseur and Wyss-Coray set out to investigate whether it had some connection to Alzheimer's disease. They hypothesized that by protecting neurons, TGF-beta may help prevent A
'"/>

Contact: Rosanne Spector
manishma@stanford.edu
650-725-5374
Stanford University Medical Center
20-Nov-2006


Page: 1 2 3

Related medicine news :

1. Sports concussion research using fMRI provides insight for safe return-to-play decisions
2. Better insight into brain anatomical structures
3. New insights into chronic inflammation and atherosclerosis
4. New insights into autoimmunity and depression
5. NIAID media availability: Examining genetic variability of malaria parasite offers insight
6. Functional brain imaging insights from UC San Diego grad student
7. Sticky proteins provide new insight into drug action
8. Laser probe of a brain pigments anatomy may offer insight into Parkinsons disease
9. New insights into the impact of pregnancy on inflammatory arthritis
10. Amnesiac study offers insights into how working memory works
11. Brain study yields insight into machinery of prejudice

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/26/2020)... ... May 26, 2020 , ... ... RevSpring solutions—Talksoft® patient messaging and IVR Advantage™--for Loyale customers. Talksoft pre-service messaging ... and precise texts, IVR reminders and email messages tailored to each stage ...
(Date:5/21/2020)... ... May 21, 2020 , ... ... the CRC’s Guide to Coordinating Clinical Research, CenterWatch eLearning , https://www.centerwatch.com/products/category/2764-elearning/product/472-the-crc-trainer ... The CRC Trainer: An Interactive Companion to the CRC’s Guide to Coordinating ...
(Date:5/21/2020)... ... ... A Safe Haven Foundation (ASHF) has been selected as one of 26 ... Fund. The fund was created in March to help nonprofits with their immediate response ... vulnerable populations in hard-hit communities. , “We are humbled and honored to be ...
(Date:5/21/2020)... ... May 21, 2020 , ... ... health management platform that supports care management and utilization management at health insurance ... client sites, TruCare 2020 provides significant usability and automation upgrades to all of ...
(Date:5/16/2020)... ... May 15, 2020 , ... On May 21, T1V will host a webinar featuring Dr. ... USC, and a contributor to CBS news, as we address COVID-19 and the impact on ... parts of the country since March, many questions are left unanswered as we look at ...
Breaking Medicine News(10 mins):
(Date:5/27/2020)... BOSTON (PRWEB) , ... May 27, 2020 , ... ... security and cloud solutions, has announced it will once again sponsor the American Heart ... for Good Champion. This will mark the third year the firm is sponsoring the ...
(Date:5/26/2020)... ... May 26, 2020 , ... SignatureCare Emergency Center, your friendly neighborhood 24-hour ... , The new ER is set to open early June, 2020, and will be ... N SH 130, Bldg.4, Pflugerville, TX. , According to Dr. Aaron Braun , ...
(Date:5/26/2020)... ... 2020 , ... Rize Health, an innovative clinical ... them with revolutionary clinical trial solutions. , Through this strategic partnership, Rize Health ... enables onboarding, scheduling, and remote data capture - right from your fingertips. The ...
Breaking Medicine Technology:
Cached News: