Morphine and topical anesthesia found effective in treating pain in newborn infants

Intravenous morphine used alone or with topical tetracaine effectively reduced levels of pain in preterm newborn infants undergoing central line insertion procedures, according to a study in the February 15 issue of JAMA.

About 10 percent to 15 percent of newborns require prolonged hospitalization for conditions such as preterm birth, birth defects, and sepsis (a blood stream infection). As part of their medical care, they are often exposed to multiple invasive procedures that may be painful. There is accumulating evidence that untreated procedural pain in newborns leads to long-term changes in pain sensitivity, according to background information in the article. The effectiveness of local or systemic analgesics (pain relievers) to minimize pain in newborns during certain procedures is not clear.

Anna Taddio, Ph.D., of the Hospital for Sick Children and University of Toronto, and colleagues studied the relative efficacy and safety of topical local anesthesia (tetracaine) and intravenous opioid analgesia (morphine), used alone or in combination, for management of pain in newborns undergoing the insertion of a central venous catheter. The randomized, double-blind, controlled trial, conducted between October 2000 and July 2005, included 132 ventilated newborns (average gestational age, 30.6 weeks at study entry). Prior to catheter insertion, the newborns were randomly assigned to receive tetracaine (n = 42), morphine (n = 38), or both (n = 31); a separate nonrandomized group of 21 neonates receiving neither tetracaine nor morphine was used as a control group.

The researchers determined pain scores by measuring the proportion of time newborns displayed facial grimacing (brow bulge) during different phases of the procedure (skin preparation, needle puncture, and recovery).

The authors found that the combination of morphine (opioid analgesia) and tetracaine (local anesthesia) was more effective than either local anesthesia alone or no ana

Contact: Laura Greer
JAMA and Archives Journals

Page: 1 2

Related medicine news :

1. Morphine kills pain -- not patients
2. Morphine and topical anaesthesia effective in treating procedural pain in newborn infants
3. Morphine for chest pain increases death risk
4. UW study tests topical honey as a treatment for diabetic ulcers
5. Short-term topical corticosteroid use may offer relief for patients with acute form of psoriasis
6. Jefferson scientists find topical lubrication helps outcomes of coronary stent procedures
7. Diagnosis of rhinitis and atopical dermatitis
8. New topical pain cream reduces pain
9. Common incontinence drug could have an additional topical effect on the bladder itself
10. New Washington study shows OB anesthesia equally safe when provided by CRNAs or anesthesiologists
11. Dental researchers test no-needle anesthesia, no-drilling cavity care

Post Your Comments:

(Date:8/31/2020)... ... August 31, 2020 , ... In an effort to give back to ... 10 percent of each hotel room booked with a special new rate code to ... Indiana (RMHC-CNI) , effective immediately. Donations will be applied to any room type, ...
(Date:8/31/2020)... (PRWEB) , ... August 31, 2020 , ... ... intended to improve outcomes for patients with advanced heart failure, today announced that ... grant in the amount of $555,358 from the National Heart, Lung, and Blood ...
(Date:8/28/2020)... ... August 28, 2020 , ... Ernst & Young ... named an Entrepreneur Of The Year® 2020 Florida Award finalist. Now in its ... ambitions deliver innovation, growth and prosperity as they build and sustain successful businesses ...
(Date:8/28/2020)... ... 28, 2020 , ... The 15 scholarships being offered by ... Wellness mobile app and web-portal. NCPCV received a 2020 grant from Motorola Solutions ... year to organizations, such as Destination Imagination, which support and advance public safety ...
(Date:8/28/2020)... ... August 28, 2020 , ... Integrated Viral Protection (IVP Air) today ... to deploy its breakthrough Mobile Biodefense Indoor Air Protection System that is the first ... plans to fully reopen equipped with the filtration system on September 8th. , ...
Breaking Medicine News(10 mins):
(Date:8/31/2020)... ... August 31, 2020 , ... If you live in New York City you will always pay ... sense, it’s the law of supply and demand, but are plastic surgeons in New York ... percentage of their patients that make the four-hour trip to have expert aesthetic treatments by ...
(Date:8/28/2020)... ... 2020 , ... Dr. Raheleh Sarbaziha has been reimagining the ... Armed with her qualifications from Ross University School of Medicine and the University ... body with the nation and world. With a fellowship in Integrative Medicine Dr. ...
(Date:8/27/2020)... ATLANTA (PRWEB) , ... August 27, 2020 , ... ... outcomes analytics, has partnered with Enquire, a leading provider of cloud CRM, marketing ... The two organizations' strategic partnership will involve the integration of Trella’s performance intelligence ...
Breaking Medicine Technology:
Cached News: