Motor symptoms associated with increased risk for future Parkinson's disease

Elderly people who complain of stiffness, loss of balance and tremors may be at increased risk for future Parkinson's disease (PD), according to a study posted online today that will appear in the April 2006 print issue of Archives of Neurology, one of the JAMA/Archives journals.

PD develops over time as neurons in certain areas of the brain that control muscle movement slowly waste away, according to background information in the article. The degeneration occurs in areas that produce a neurotransmitter known as dopamine. Typical symptoms of PD--including severe tremors, rigidity and slow movements--begin when the brain loses more than half of its dopamine production ability.

Lonneke M. L. de Lau, M.D., and colleagues at the Erasmus Medical Center, Rotterdam, the Netherlands, hypothesized that individuals who were developing PD might experience some other, milder symptoms before clinically recognizable symptoms of PD occur. They examined 6,038 elderly people who did not have PD or dementia. The participants answered questions about their motor skills, including whether they had experienced stiffness, tremors, falling, slowness or a feeling of imbalance. More than half of them reported at least one of these complaints. They were then assessed for PD at two follow-up visits and their medical records were analyzed.

Over the course of the study, which followed participants for an average of 5.8 years, people who had initially reported stiffness, tremors or imbalance were more likely to develop PD than those who had not. Of the 56 people who developed PD during the study, 71.8 percent had reported at least one motor complaint and 41 percent at least two.

"Our findings support the notion that clinically manifest PD is preceded by a preclinical phase that is not entirely asymptomatic," the authors report. "Subjective complaints related to motor function might indicate a very early phase of not-yet-diagnosable PD during which dopamin

Contact: Monique M.B. Breteler, M.D., Ph.D.
JAMA and Archives Journals

Page: 1 2

Related medicine news :

1. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
2. New treatment effective in counteracting cocaine-induced symptoms
3. Women with migraines and visual symptoms may have higher stroke risk
4. Students with symptoms of mental illness often dont seek help
5. Children with sleep disorder symptoms are more likely to have trouble academically
6. Antidepressant does not improve symptoms in advanced cancer patients without major depression
7. Focused ultrasound relieves fibroid symptoms in women
8. Investigational nonstimulant Guanfacine XR significantly improved child, adolescent ADHD symptoms
9. Erectile dysfunction and lower urinary tract symptoms
10. Marijuana worsens COPD symptoms in current cigarette smokers
11. Full-term, low-birth-weight babies at significantly greater risk for early respiratory symptoms

Post Your Comments:

(Date:4/5/2020)... ... , ... Given the current pandemic and economic crisis, it is important to ... can rise to several thousand dollars per year. It all depends on several factors, ... and so on. Drivers can get better rates if they: , ...
(Date:4/2/2020)... ... 02, 2020 , ... LifeLearn Animal Health , in partnership with the ... the veterinary CE course COVID-19: What we know and don’t know with Dr. ... comes to COVID-19, it’s important for practices and pet owners to get the facts,” ...
(Date:4/2/2020)... ... 02, 2020 , ... Since the onset of the COVID-19 pandemic, there hasn’t ... ( https://www.goparrot.ai/ ) founder Yaniv Nissim has stepped up to the plate to ... safety, has created new standards for delivering food during this time of COVID-19 so ...
(Date:4/1/2020)... ... 02, 2020 , ... AAGL Gynecologic Surgeons host a global ... surgical safety practices in response to the COVID-19 crisis. , AAGL frontline ... New Orleans and Amsterdam University Medical Center in the Netherlands will discuss what ...
(Date:4/1/2020)... (PRWEB) , ... April 01, 2020 , ... According to ... of reproductive age (13-44) in need of publicly funded contraception live in counties ... Nearly one-quarter of Minnesota’s counties have lost some or all of their Title X ...
Breaking Medicine News(10 mins):
(Date:4/5/2020)... CLARA, Calif. (PRWEB) , ... April 04, 2020 ... ... wave of COVID-19 infections, urgent needs arise for medical supplies, diagnostics, and treatments. ... patients and medical professionals at risk. , Tran & Associates supports ...
(Date:4/2/2020)... ... 02, 2020 , ... Caitlin Richardson, a University of Washington ... Spring Semester Scholarship. , The $1,000 scholarship, awarded biannually to U.S. students ... at helping the students pay tuition and other college-related expenses. , Rhonda Abbe, ...
(Date:4/1/2020)... ... 2020 , ... The new platform/service titled “Behind the ... broadcast premiering on April 2. , The live broadcasts will be at 2:30 ... keepers and veterinary hospital staff with different animals. The interactive component allows subscribers ...
Breaking Medicine Technology:
Cached News: