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NHLBI awards 12 Women's Health Initiative contracts

al Study, the team will examine associations between physical activity and inflammatory markers and whether these associations vary by a person's weight. They will also look at joint associations between physical activity combined with weight/obesity status and risk of CHD. The role of inflammatory markers in mediating the associations of physical activity and weight with CHD risk will be studied and compared with the role of traditional risk factors such as blood pressure and cholesterol levels.

  • "Endogenous Estradiol and the Effects of Estrogen Therapy on Major Outcomes of WHI, California Pacific Medical Center, San Francisco, Steven R Cummings, M.D. The investigators will study how baseline levels of the estrogen molecule, estradiol, and of sex hormone binding globulin (SHBG), a protein that binds to testosterone and estradiol, relate to treatment effects of hormone therapy on coronary heart disease (CHD), stroke, blood clots, fractures, breast cancer, dementia, and mild cognitive impairment. The team will test for interaction of baseline hormone levels with treatment effects of hormone therapy.

  • "Identification and Validation of Circulating Biomarkers for the Early Detection of Breast Cancer in Pre-Clinical Specimens, Fred Hutchinson Cancer Research Center, Seattle, WA, Christopher Li, M.D., Ph.D. Using three different proteomics techniques, the investigators hope to identify proteins associated with breast cancer as well as biomarkers that could potentially be used for early detection of breast cancer.

  • "Proteomics and the Health Effects of Postmenopausal Hormone Therapy, Fred Hutchinson Cancer Research Center, Seattle, WA, Ross Prentice, Ph.D. Dr. Prentice and his research team will study over 1,000 proteins, in order to identify a small number of proteins potentially associated with CHD, stroke, breast cancer, colon cancer, or hip fractures in participants in the WHI Observational Study. Together with other ongoing studies in the h
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  • Contact: NHLBI Communications Office
    nhlbi_news@nhlbi.nih.gov
    301-496-4236
    NIH/National Heart, Lung, and Blood Institute
    29-Jan-2007


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