NHLBI awards 12 Women's Health Initiative contracts

ormone trials, this work may lead to the identification of markers of future disease, and how these markers relate to the effects of hormone therapy.

  • "High-Dimensional Genotype in Relation to Breast Cancer and WHI Clinical Trial Interventions, Fred Hutchinson Cancer Research Center, Seattle, WA, Ross Prentice, Ph.D. This genome-wide association study will examine genetic variations associated with breast tumor characteristics. Since the studies are being done in women participating in the hormone therapy, calcium-vitamin D, and low fat diet trials and the investigators will have access to blood hormone and vitamin D levels in many of these WHI participants, they hope to explore biologic pathways by relating treatments, blood levels, and genes to breast cancer.

  • "Genome-wide Association Study to Identify Genetic Components of Hip Fracture, Ohio State University, Columbus, OH, Rebecca Jackson, M.D. Dr. Jackson and colleagues will seek to identify common genetic variants that affect the risk for hip fracture in postmenopausal women participating in the WHI Clinical Trial and the Observational Study. This will be the first genome-wide association study of hip fractures. Due to advances in technology, the entire genome can now be scanned; in the first stage of this research project, the scientists will study 500,000 genetic variants, and those that look promising will be specifically investigated in the two subsequent stages.

  • "Predictive Value of Nutrient Biomarkers for Coronary Heart Disease Death, Tufts University, Boston, MA, Alice Lichtenstein, D.Sc. Dr. Lichtenstein and colleagues will determine the value of selected nutrient biomarker plasma concentrations (trans fatty acids, very long chain omega-3 fatty acids, phylloquinone, dihydrophylloquinone) in women who participated in the WHI Observational Study and died of CHD. The predictive value of these data relative to self-reported food intake will also be assessed. The re

  • Contact: NHLBI Communications Office
    NIH/National Heart, Lung, and Blood Institute

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