NHLBI awards 12 Women's Health Initiative contracts

sults of this work will be of value in defining optimal approaches to evaluating the impact of dietary patterns on CHD risk in large groups of individuals.

  • "Ancestry Association Analyses of WHI Traits, University of California, Davis, CA, Michael Seldin, M.D., Ph.D. The investigators will examine the contribution of ancestry informative markers (AIMS) in DNA samples to differences in risk of CHD, stroke, breast cancer, and hip fractures in Blacks and Hispanics. They will also analyze genetic factors related to ancestry or country of origin affecting hip fracture and bone mineral density in Whites, and bone mineral density in Blacks. The results will be a valuable resource to assist other researchers who wish to combine data of minority groups with that of Whites.

  • "Biochemical Antecedents of Fracture in Minority Women, University of Pittsburgh, Pittsburgh, PA, Jane Cauley, Dr.P.H. This study will examine risk markers for fracture in groups of minority and white women. This study will be the first comprehensive investigation of biochemical factors leading to fracture in minority women. The results promise to explain differences in fracture rates and to help target prevention strategies.

  • "Hormone Therapy, Estrogen Metabolism and Risk of Breast Cancer or Hip Fracture in the WHI Hormone Trial, University of Pittsburgh, Pittsburgh, PA, Lewis Kuller, M.D., Dr.P.H. The goal of this study is to determine whether differences in estrogen metabolism in untreated women and women on estrogen or estrogen plus progestin determine risk of hip fracture and breast cancer. The research team will measure levels of two estrogen metabolites and evaluate their role as biomarkers of breast cancer and hip fracture. They will study whether estrogen metabolism differs by whether or not the estrogen is opposed by a progestin and if how a woman metabolizes estrogen on hormone therapy relates to the risk of hip fracture.

  • "Interactio

  • Contact: NHLBI Communications Office
    NIH/National Heart, Lung, and Blood Institute

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