HOME >> MEDICINE >> NEWS
NIAID scientists unveil mechanism behind resistance to severe malaria

Scientists have discovered why people with a specific type of hemoglobin--the oxygen-carrying molecule that gives red blood cells their color--are less prone to severe malaria. In a series of experiments, the researchers determined how hemoglobin type C impairs the ability of malaria parasites to cause disease symptoms.

"This research gives us a new insight into malaria, a major global killer that preys especially on young children and claims a life every 30 seconds," notes Anthony S. Fauci, M.D., director of the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, where the research was conducted.

"If we better understand the natural protective mechanisms against malaria, we might be able to mimic that protective effect through vaccines or drugs," says NIAID researcher Thomas E. Wellems, M.D., Ph.D., whose team's findings appear this week in the journal Nature.

Hemoglobin exists in several varieties. Hemoglobin A is the most common, but in parts of West Africa, where malaria is rife, one-fourth of the population has at least one gene for hemoglobin C. Children with at least one hemoglobin C gene are less prone to deadly cerebral malaria, in which parasite-infected red blood cells accumulate in the brain. But how hemoglobin C confers this protection has puzzled scientists until now.

To solve the mystery, Dr. Wellems and his colleagues studied laboratory-infected red blood cells and blood drawn from children with malaria from the African nation of Mali. Genetically, the samples fell into three groups: those with two genes for hemoglobin A (AA); those with two genes for hemoglobin C (CC); or those with one gene for each type of hemoglobin (AC).

The scientists then measured three phenomena that affect how well parasitized red blood cells can be made to stick to one another, to uninfected red blood cells and to blood vessel walls. These phenomena--known respectively as aggl
'"/>

Contact: Anne A. Oplinger
aoplinger@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
22-Jun-2005


Page: 1 2

Related medicine news :

1. NIAID releases MDR/XDR Tuberculosis research agenda
2. NIAID DNA vaccine for H5N1 avian influenza enters human trial
3. NIAID media availability: Examining genetic variability of malaria parasite offers insight
4. NIAID awards $4 million to develop anti-radiation treatments
5. Partnership between NIAID and Sequella yields promising new TB drug for clinical testing
6. NIAID announces leadership for newly restructured HIV/AIDS clinical trials networks
7. NIAID study finds higher dose of flu vaccine improves immune response in the elderly
8. NIAID media availability: New study describes key protein from highly pathogenic H5N1 avian flu virus and how it might mutate
9. NIAID media availability: Understanding influenza infection
10. NIAID researchers show how promising TB drug works
11. NIAID awards $47 million to develop medical countermeasures against radiological, nuclear threats

Post Your Comments:
(Date:4/19/2015)... Lowcostcarinsuranceprice.com has released a new blog post ... arrested for DUI. The blog post also discusses the ... , Some pills can have dangerous side effects ... are under medication should ask their doctor’s advice before ... be considered driving under the influence and clients can ...
(Date:4/19/2015)... A live auction will be held to sell over 4,800 ... NY and other national consignors. Various types of equipment will ... much more. , The auction will take place Tuesday, ... each day. The equipment is at their Chicago warehouse located ... Anyone can participate in the auction including those who cannot ...
(Date:4/18/2015)... (PRWEB) April 19, 2015 For some people, ... proudly display for the rest of their lives, as they ... them and put in a great amount of thought on ... whim, they have outgrown them or simply want them removed ... people regret their tattoo, and in 2012-13 there was a ...
(Date:4/18/2015)... Carinsurancehints.com has released a new blog post explaining how to ... against fire damage. , Clients can now find auto ... is set intentionally on fire. This type of damages can ... things. , It is possible to compare the best ... , in just a few minutes. Clients should always ...
(Date:4/18/2015)... Lowcostcarinsuranceprice.com has released a new blog post explaining the ... prices . , Drivers who live in states ... to pay more for auto insurance plans that provide ... offer protection against vehicle theft. , Affordable auto ... single website: http://lowcostcarinsuranceprice.com/ . Drivers who own ...
Breaking Medicine News(10 mins):Health News:Driving On Medication - Possible Effects On Auto Insurance Prices 2Health News:Centurion to Sell Surplus Medical Equipment in Online and On-Site Auction 2Health News:Dennis Dass, M.D. is Shattering the Past While Revealing the Future 2Health News:Online Auto Insurance Quotes For Plans That Cover Fire Damages! 2Health News:High Rates Of Car Theft Can Have An Impact on Auto Insurance Prices! 2
(Date:4/17/2015)... DUBLIN , Apr. 17, 2015 Research ... announced the addition of the "Medical Device ... to their offering. This report analyzes ... US$ Million by the following Device Categories: Class ... areas also analyzed in the report Include - ...
(Date:4/17/2015)... 17, 2015 ASSESS shows   ... is a viable alternative to tumour biopsy   ... patients with advanced NSCLC   AstraZeneca today presented ... circulating tumour DNA (ctDNA) testing for epidermal growth factor receptor ... cell lung cancer (NSCLC) in clinical practice. [ 1 ...
(Date:4/17/2015)... 17, 2015 Research and Markets ( ... "Medical Oxygen Systems - Global Strategic Business Report" ... the worldwide markets for Medical Oxygen Systems in US$ ... Systems, Oxygen Cylinders & Regulators, and Oxygen Conserving Devices. ... Canada , Japan ...
Breaking Medicine Technology:Medical Device Outsourcing (Radiology, Orthopedic, Neurology, Cardiology, and Others) Market 2015 - Global Strategic Business Report 2Medical Device Outsourcing (Radiology, Orthopedic, Neurology, Cardiology, and Others) Market 2015 - Global Strategic Business Report 3"Real World" Data Support Use of Blood Test for EGFR Mutation in Advanced NSCLC 2"Real World" Data Support Use of Blood Test for EGFR Mutation in Advanced NSCLC 3"Real World" Data Support Use of Blood Test for EGFR Mutation in Advanced NSCLC 4Medical Oxygen Systems - 2015 Global Strategic Business Report Featuring Leading Players, Caire, Invacare & Philips Respironics 2
Cached News: