HOME >> MEDICINE >> NEWS
NIAID scientists unveil mechanism behind resistance to severe malaria

Scientists have discovered why people with a specific type of hemoglobin--the oxygen-carrying molecule that gives red blood cells their color--are less prone to severe malaria. In a series of experiments, the researchers determined how hemoglobin type C impairs the ability of malaria parasites to cause disease symptoms.

"This research gives us a new insight into malaria, a major global killer that preys especially on young children and claims a life every 30 seconds," notes Anthony S. Fauci, M.D., director of the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, where the research was conducted.

"If we better understand the natural protective mechanisms against malaria, we might be able to mimic that protective effect through vaccines or drugs," says NIAID researcher Thomas E. Wellems, M.D., Ph.D., whose team's findings appear this week in the journal Nature.

Hemoglobin exists in several varieties. Hemoglobin A is the most common, but in parts of West Africa, where malaria is rife, one-fourth of the population has at least one gene for hemoglobin C. Children with at least one hemoglobin C gene are less prone to deadly cerebral malaria, in which parasite-infected red blood cells accumulate in the brain. But how hemoglobin C confers this protection has puzzled scientists until now.

To solve the mystery, Dr. Wellems and his colleagues studied laboratory-infected red blood cells and blood drawn from children with malaria from the African nation of Mali. Genetically, the samples fell into three groups: those with two genes for hemoglobin A (AA); those with two genes for hemoglobin C (CC); or those with one gene for each type of hemoglobin (AC).

The scientists then measured three phenomena that affect how well parasitized red blood cells can be made to stick to one another, to uninfected red blood cells and to blood vessel walls. These phenomena--known respectively as aggl
'"/>

Contact: Anne A. Oplinger
aoplinger@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
22-Jun-2005


Page: 1 2

Related medicine news :

1. NIAID releases MDR/XDR Tuberculosis research agenda
2. NIAID DNA vaccine for H5N1 avian influenza enters human trial
3. NIAID media availability: Examining genetic variability of malaria parasite offers insight
4. NIAID awards $4 million to develop anti-radiation treatments
5. Partnership between NIAID and Sequella yields promising new TB drug for clinical testing
6. NIAID announces leadership for newly restructured HIV/AIDS clinical trials networks
7. NIAID study finds higher dose of flu vaccine improves immune response in the elderly
8. NIAID media availability: New study describes key protein from highly pathogenic H5N1 avian flu virus and how it might mutate
9. NIAID media availability: Understanding influenza infection
10. NIAID researchers show how promising TB drug works
11. NIAID awards $47 million to develop medical countermeasures against radiological, nuclear threats

Post Your Comments:
(Date:11/27/2014)... HealthDay Reporter WEDNESDAY, Nov. 26, 2014 ... safe and produces an immune system response that could protect ... results reported by the U.S. National Institutes of Health. ... vaccine paves the way for field-testing it in the Ebola-stricken ... as January, said Dr. Anthony Fauci, director of the NIH,s ...
(Date:11/27/2014)... Now that Thanksgiving is finally here ... Emassagechair.com has announced its eagerly awaited, once ... , Negotiating on behalf of their customers, and drawing ... Emassagechair.com has generated significant buzz in the industry with ... yet. , Shoppers are excited for significant savings available ...
(Date:11/27/2014)... November 27, 2014 “LAB.C” was featured on ... the latest and coolest technology products available to consumers. Mallory ... product review and shared with viewers the company ... and Android devices. , Consumers love portability and functionality. ... Cable Case for the iPhone5 and 5S has a portable ...
(Date:11/27/2014)... Aria Health President and CEO ... and donated 200 Thanksgiving dinners on Friday, November ... a non-profit, community-based organization committed to serving vulnerable ... dinners were assembled in the dining hall of ... to vulnerable low income seniors in the Philadelphia ...
(Date:11/27/2014)... India (PRWEB) November 27, 2014 Ethane ... company, has announced online reputation management service. ... a comprehensive study about the world of internet marketing ... and Yahoo. , Ethane Web Technologies does not ... it first analyzes the project to reach a conclusion ...
Breaking Medicine News(10 mins):Health News:Early Trial Promising for Ebola Vaccine 2Health News:Early Trial Promising for Ebola Vaccine 3Health News:Emassagechair.com is Excited to Announce Their Biggest Discount Event of the Year, Starting the Day After Thanksgiving and Lasting Through The Holiday Weekend. 2Health News:Emassagechair.com is Excited to Announce Their Biggest Discount Event of the Year, Starting the Day After Thanksgiving and Lasting Through The Holiday Weekend. 3Health News:Emassagechair.com is Excited to Announce Their Biggest Discount Event of the Year, Starting the Day After Thanksgiving and Lasting Through The Holiday Weekend. 4Health News:Top Mobile Friendly Accessories were Featured on NewsWatch Television on October 30, 2014 2Health News:Aria Health Prepares and Donates 200 Thanksgiving Dinners 2Health News:Ethane Web Technologies Announces Online Reputation Management Service 2
(Date:11/26/2014)... , Nov. 26, 2014  Thoratec Corporation (NASDAQ: ... circulatory support therapies to save, support and restore failing ... upcoming investor conferences. On Tuesday, December 2, ... Annual Piper Jaffray Healthcare Conference.  D. Keith Grossman ... update on the company beginning at 11:30 a.m., Eastern ...
(Date:11/26/2014)... 26, 2014  Perrigo Company plc ("Perrigo") (NYSE: ... "Quality Affordable Healthcare Products®," today announced the closing of ... sale of 6,809,210 ordinary shares at a public offering ... of the option to purchase up to an additional ... Barclays Capital Inc., as representatives of the several underwriters. ...
(Date:11/26/2014)... Texas , Nov. 26, 2014 ... today announced the completion of previously announced concurrent ... million.  After fees and estimated offering expenses, Lexicon ... the transactions.  The transactions consisted of: ... common stock, pursuant to a registration statement that ...
Breaking Medicine Technology:Thoratec Announces Presentations At Investor Conferences For December 2014 2Perrigo Company plc Announces The Closing Of Its Registered Public Offering Of Ordinary Shares 2Perrigo Company plc Announces The Closing Of Its Registered Public Offering Of Ordinary Shares 3Perrigo Company plc Announces The Closing Of Its Registered Public Offering Of Ordinary Shares 4Lexicon Announces Completion Of $280 Million In Financing Transactions 2Lexicon Announces Completion Of $280 Million In Financing Transactions 3
Cached News: