HOME >> MEDICINE >> NEWS
NIAID study finds higher dose of flu vaccine improves immune response in the elderly

virus infects so many people--some 5 to 20 percent of the U.S. population every year.

In other influenza vaccine studies, higher antibody levels resulted in better protection against infection. Conversely, decreased antibody production in the elderly can leave them more susceptible to infection and the severe complications of influenza. Helping elderly people increase antibody production should help them fight off influenza infections, and this is exactly what Dr. Keitel and her colleagues set out to test when they began the clinical trial. They hypothesized that elderly people could be given higher doses of vaccine safely and that these higher doses would increase the antibody response and confer increased protection without increasing side effects.

In the study, the investigators randomly assigned 202 adults 65 years of age or older into four equal-sized groups: those receiving the normal dose of vaccine (15 micrograms); twice the normal dose (30 micrograms); four times the normal dose (60 micrograms); or a placebo. The average age of the volunteers was 72.4 years. All study participants were followed for a month post-vaccination to look for any vaccine-related side effects and to collect blood to evaluate antibody responses.

Dr. Keitel and her colleagues found that participants in the high-dose group (60 micrograms) had 44 to 79 percent higher levels of antibody than did those who received the normal dose of vaccine. Higher doses also increased the number of elderly volunteers achieving levels of antibody that have been associated with protection against influenza. Moreover, the vaccine was well-tolerated at all dosage levels. Although the higher doses of vaccine caused more mild side effects at the injection site, there were no significant differences in systemic symptoms such as fever or body aches among the groups.

The successful achievement of higher levels of antibodies in this study suggests that larger doses of vaccine
'"/>

Contact: Jason Bardi
jbardi@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
22-May-2006


Page: 1 2 3

Related medicine news :

1. NIAID releases MDR/XDR Tuberculosis research agenda
2. NIAID DNA vaccine for H5N1 avian influenza enters human trial
3. NIAID media availability: Examining genetic variability of malaria parasite offers insight
4. NIAID awards $4 million to develop anti-radiation treatments
5. Partnership between NIAID and Sequella yields promising new TB drug for clinical testing
6. NIAID announces leadership for newly restructured HIV/AIDS clinical trials networks
7. NIAID media availability: New study describes key protein from highly pathogenic H5N1 avian flu virus and how it might mutate
8. NIAID media availability: Understanding influenza infection
9. NIAID researchers show how promising TB drug works
10. NIAID awards $47 million to develop medical countermeasures against radiological, nuclear threats
11. NIAID launches first Phase II trial of a global HIV/AIDS vaccine

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/9/2018)... ... November 09, 2018 , ... ... specializes in the treatment of autism and other developmental disabilities, is pleased to ... effort to address the service gap and alarming rise in Autism Spectrum Disorder ...
(Date:11/9/2018)... ... November 08, 2018 , ... ... Caring Transitions Ann Arbor. , Caring Transitions’ specially-trained team can handle organizing, packing, ... market. Caring Transitions specializes in assisting seniors, but their services are great for ...
(Date:11/9/2018)... ... November 08, 2018 , ... Dr. ... to provide advanced skin rejuvenation with NovaThreads® , a non-surgical alternative to ... with surgical sutures made of polydioxanone (PDO), a fully-dissolvable thread used in cardio-thoracic ...
(Date:11/8/2018)... ANGELES (PRWEB) , ... November 08, 2018 , ... For ... return from war. They often face immense challenges as they transition to civilian life, ... occasion to honor their service and support solutions that can improve their lives. The ...
(Date:11/8/2018)... LEHI, Utah (PRWEB) , ... November 08, 2018 , ... ... of Top Workplaces. , The 2018 list is compiled solely on employee feedback ... including alignment, execution, and connection, just to name a few. , “We strive to ...
Breaking Medicine News(10 mins):
(Date:11/8/2018)... SPRINGS, Texas (PRWEB) , ... November 08, 2018 ... ... Pueblo, Colorado has selected its patient electronic signatures and eForms solution . ... has been designated as its region’s first certified Stroke Center, has deployed this ...
(Date:11/8/2018)... THOUSAND OAKS, Calif. (PRWEB) , ... November 08, ... ... to announce the formation of a partnership in which Implant Direct will provide ... Dental consists of 1,400 supported doctors working in more than 875 offices in ...
(Date:11/8/2018)... ... November 08, 2018 , ... ... and analytics solution, today announced the results of a new survey on data ... CIOs and other senior healthcare IT leaders. Overall, it found few organizations have ...
Breaking Medicine Technology:
Cached News: