HOME >> MEDICINE >> NEWS
NIH funding UIC brain tumor research

Researchers at the University of Illinois at Chicago College of Pharmacy have received a $1.7 million five-year federal grant to develop a new approach to treat brain tumors.

A hydrogel-based delivery system, similar in consistency to gelatin, has been developed to control the release of chemotherapy drugs that will kill glioblastoma multiforme, the most advanced and invasive form of brain tumor, and other solid tumors, said Richard Gemeinhart, assistant professor in the departments of biopharmaceutical sciences and bioengineering and lead researcher of the study. The novel approach stabilizes the drug and provides better control of the time and location of its activity, thereby reducing its side effects.

Gemeinhart said the drug will be activated from the hydrogel through the overactivity of matrix metalloproteases, enzymes that renew extracellular matrix in tissue that include the joints.

Approximately 40,000 people are diagnosed each year with a new brain tumor, according to the National Institutes of Health. Of these new tumors, 50 percent are primary and 50 percent have originated in other parts of the body and traveled to the brain.

Brain tumors are the third leading cause of death from cancer in individuals ages 20 to 39; about 13,000 people die of malignant brain tumors each year in the United States. About 1,500 children in the U.S. are diagnosed with a brain tumor each year.

Surgery followed by chemotherapy is the primary treatment for glioblastoma multiforme, Gemeinhart said. However, surgery alone cannot completely treat the disease or prevent its recurrence. The chemotherapy drugs currently used are limited due to systemic toxicity, resistance, and their inability to efficiently cross the blood brain barrier, he said.

"Our understanding of the disease suggests that localizing chemotherapy to the tumor resection site can improve survival," Gemeinhart said. "Currently, the mean survival time f
'"/>

Contact: Sam Hostettler
samhos@uic.edu
312-355-2522
University of Illinois at Chicago
8-May-2007


Page: 1 2

Related medicine news :

1. SCHIP funding levels too low ACP tells Senate Finance Committee Leaders
2. Physician-researchers often less successful in obtaining NIH funding
3. Research ethics committees in Africa report inadequate funding, staffing and training
4. Nutrition studies conclusions tied to funding source
5. European scientists receive funding from EU to develop novel therapy for cancer
6. University of Rochester spin-off secures $2 million in funding
7. Independent evaluation finds GAVI funding to poor countries can boost childhood vaccine coverage
8. Clean water project hit by funding drought
9. Projected costs of stroke highlight need for increased NIH funding
10. US trumps Europe in public funding for cancer research
11. New funding for research in primary health care

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/20/2017)... 20, 2017 (PRWEB) , ... ... ... a global provider of enterprise-grade IT operations analytics and application performance monitoring ... one of world’s largest healthcare services providers. , According to Peter Ohrenberger, ...
(Date:7/20/2017)... ... ... Doctors on Liens, the leading network of medical providers working on a ... Russell Horine, DC to their exclusive list of medical professionals. Horine Chiropractic is a ... the clinic director and his son Dr. Lee Horine and daughter-in-law Dr. Natalie Horine ...
(Date:7/20/2017)... ... July 20, 2017 , ... TCGRx announced today ... existing adherence automation lines. The ATP® Mini and InspectRx® Mini are ... standard products, but at a size and price point that can help pharmacies ...
(Date:7/20/2017)... (PRWEB) , ... July 20, 2017 , ... LINET, an ... latest innovation to their product line: the AVE 2 birthing bed. , Perfectly suitable ... bring a new level of comfort and efficiency to every phase of childbirth. The ...
(Date:7/20/2017)... ... July 19, 2017 , ... ... million Health Resources and Services Administration (HRSA) grant to train predoctoral dental students ... care needs in rural and underserved areas. , The Predoctoral Pediatric Training Project ...
Breaking Medicine News(10 mins):
(Date:7/11/2017)... , July 11, 2017  The global market for ... of approximately $394.1 million in 2016.  Although in early ... solid growth, in particular as a result of the ... and the recent introduction of a significant number of ... less-invasive testing of tumor biomarkers to guide treatment decisions. ...
(Date:7/11/2017)... , July 11, 2017 Oramed Pharmaceuticals ... a clinical-stage pharmaceutical company focused on the development of ... Food and Drug Administration (FDA) has agreed to schedule ... completed Phase IIb trial of its oral insulin capsule ... Phase IIb trial met primary and secondary endpoints by ...
(Date:7/10/2017)... S.C. , July 10, 2017  BDI ... purchasing and patient support services organization serving specialty ... today the launch of four significant, value-added member ... market insights, better manage reimbursement and improve access ... and factor therapies. ...
Breaking Medicine Technology:
Cached News: