NIH funding UIC brain tumor research

Researchers at the University of Illinois at Chicago College of Pharmacy have received a $1.7 million five-year federal grant to develop a new approach to treat brain tumors.

A hydrogel-based delivery system, similar in consistency to gelatin, has been developed to control the release of chemotherapy drugs that will kill glioblastoma multiforme, the most advanced and invasive form of brain tumor, and other solid tumors, said Richard Gemeinhart, assistant professor in the departments of biopharmaceutical sciences and bioengineering and lead researcher of the study. The novel approach stabilizes the drug and provides better control of the time and location of its activity, thereby reducing its side effects.

Gemeinhart said the drug will be activated from the hydrogel through the overactivity of matrix metalloproteases, enzymes that renew extracellular matrix in tissue that include the joints.

Approximately 40,000 people are diagnosed each year with a new brain tumor, according to the National Institutes of Health. Of these new tumors, 50 percent are primary and 50 percent have originated in other parts of the body and traveled to the brain.

Brain tumors are the third leading cause of death from cancer in individuals ages 20 to 39; about 13,000 people die of malignant brain tumors each year in the United States. About 1,500 children in the U.S. are diagnosed with a brain tumor each year.

Surgery followed by chemotherapy is the primary treatment for glioblastoma multiforme, Gemeinhart said. However, surgery alone cannot completely treat the disease or prevent its recurrence. The chemotherapy drugs currently used are limited due to systemic toxicity, resistance, and their inability to efficiently cross the blood brain barrier, he said.

"Our understanding of the disease suggests that localizing chemotherapy to the tumor resection site can improve survival," Gemeinhart said. "Currently, the mean survival time f

Contact: Sam Hostettler
University of Illinois at Chicago

Page: 1 2

Related medicine news :

1. SCHIP funding levels too low ACP tells Senate Finance Committee Leaders
2. Physician-researchers often less successful in obtaining NIH funding
3. Research ethics committees in Africa report inadequate funding, staffing and training
4. Nutrition studies conclusions tied to funding source
5. European scientists receive funding from EU to develop novel therapy for cancer
6. University of Rochester spin-off secures $2 million in funding
7. Independent evaluation finds GAVI funding to poor countries can boost childhood vaccine coverage
8. Clean water project hit by funding drought
9. Projected costs of stroke highlight need for increased NIH funding
10. US trumps Europe in public funding for cancer research
11. New funding for research in primary health care

Post Your Comments:

(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Global Healthcare ... scenic Alexandria Park in Milford, NJ. This free event, sponsored by Global Healthcare ... activity. The fun run is geared towards children of all ages; it is ...
(Date:10/13/2017)... ... ... Journey: From the Mountains to the Mission Field”: the story of a missionary couple ... From the Mountains to the Mission Field” is the creation of published author, Carole ... and currently teaches a class of ladies at her church, which she has taught ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of ... announced today its plans to open a flagship location in Covington, LA at 401 ... Rooms To Go store next to Office Depot in the Holiday Square shopping center. ...
(Date:10/12/2017)... ... October 12, 2017 , ... Asante, a nationally recognized health ... expanded their existing home health joint venture through an agreement, effective October 1, ... joint venture home health company with Asante, delivering clinically integrated care, for the ...
(Date:10/12/2017)... ... ... Leading pediatric oncology experts at Children’s National Health System will join ... International Society of Paediatric Oncology (SIOP) Oct. 12-15. Chaired by Jeffrey Dome, ... at Children’s National, and Stephen P. Hunger, M.D., Chief of the Division of ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... Halo Labs announces the European launch of their new low volume, ... 2017 in Cambridge, U.K on October 4th. ... samples with unprecedented speed and sensitivity while using far less sample ... ... system ...
(Date:9/27/2017)... NEW YORK , Sept. 27, 2017  DarioHealth Corp. (NASDAQ: DRIO), ... solutions, today announced that its MyDario product is expected to appear on ... for when The Dr. Oz Show airs in your area: http://www.doctoroz.com/page/where-watch-dr-oz-show ... The nine-time Emmy award-winning, The Dr. ... ...
(Date:9/22/2017)... -- AVACEN Medical (AVACEN) announced that its CE-Marked AVACEN ... with the widespread pain associated with fibromyalgia in the ... Essex, England commented, "I had difficulty ... sleep at all, tremendous pain, with every movement sending ... AVACEN 100] enough, how this has and is helping ...
Breaking Medicine Technology:
Cached News: