HOME >> MEDICINE >> NEWS
NIH scientists target future pandemic strains of H5N1 avian influenza

Preparing vaccines and therapeutics that target a future mutant strain of H5N1 influenza virus sounds like science fiction, but it may be possible, according to a team of scientists at the National Institute of Allergy and Infectious Diseases (NIAID), a component of the National Institutes of Health (NIH), and a collaborator at Emory University School of Medicine. Success hinges on anticipating and predicting the crucial mutations that would help the virus spread easily from person to person.

Led by Gary Nabel, M.D., Ph.D., director of the NIAIDs Dale and Betty Bumpers Vaccine Research Center (VRC), the team is reporting in the August 10, 2007 issue of the journal Science that they have developed a strategy to generate vaccines and therapeutic antibodies that could target predicted H5N1 mutants before these viruses evolve naturally. This advance was made possible by creating mutations in the region of the H5N1 hemagglutinin (HA) protein that directs the virus to bird or human cells and eliciting antibodies to it.

What Dr. Nabel and his colleagues have discovered will help to prepare for a future threat, says NIH Director Elias A. Zerhouni, M.D. While nobody knows if and when H5N1 will jump from birds to humans, they have come up with a way to anticipate how that jump might occur and ways to respond to it.

Now we can begin, preemptively, to consider the design of potential new vaccines and therapeutic antibodies to treat people who may someday be infected with future emerging avian influenza virus mutants, says NIAID Director Anthony S. Fauci, M.D. This research could possibly help to contain a pandemic early on.

Making a vaccine against an existing strain of H5N1 or any other type of influenza virus is relatively routine. Typically, samples of existing influenza virus strains are isolated and then grown inside eggs or in cell cultures. The virus is then collected, inactivated, purified and added to the other components o
'"/>

Contact: Jason Socrates Bardi
jbardi@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
9-Aug-2007


Page: 1 2 3

Related medicine news :

1. Barrow scientists make headlines for their research on fixational eye movements
2. UD scientists invent novel hydrogels for repairing, regenerating human tissue
3. UK scientists set their sights on cure for AMD
4. Fat protein cuts blood vessel inflammation, may help heart, Jefferson scientists find
5. Smart mice teach scientists about learning process, brain disorders
6. Why predicting the next influenza pandemic is difficult and how scientists can best prepare
7. Sex and prenatal hormone exposure affect cognitive performance, Yerkes scientists find
8. AACR awards minority and other underrepresented scientists
9. Jefferson scientists find that plavix appears to be safe during and after heart bypass
10. Jefferson scientists find that drug-eluting stents are disappointing in bypass grafts -- sometimes
11. Forsyth scientists wiping out tooth decay through school-based cavities prevention program

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: NIH scientists target future pandemic strains avian influenza

(Date:7/23/2014)... By 2013, there were about ... equipment in China, including about 320 related enterprises ... and remaining more than 200 enterprises mainly engaging ... end of 2013, the total output value of ... billion, accounting for 55.94% of the dust-collecting equipment’s ...
(Date:7/23/2014)... “Unlike most Sales Training Programs, the Sales ... unique gifts, talents and abilities as opposed to giving ... Ja Marr Brown. It is based on ... transformation from nearly getting fired for poor sales performance ... sales contest offered and taking a last placed sales ...
(Date:7/23/2014)... The age spots, wrinkles and puffy eyes that can ... are now explored in a new guide posted at the ... women over 30 are introduced in the guide as well ... use of creams as an alternative to surgery is one ... to the information in the new guide. Because there are ...
(Date:7/23/2014)... adults living near Sellafield or Dounreay since the 1990s ... according to research published in the British Journal ... Childhood Cancer Research Group at the University of Oxford ... and 2006 among those who were under 25 and ... was found in cancer incidence from 1991-2006 between those ...
(Date:7/23/2014)... from the University of Exeter has developed a ... a frequently fatal lung disease which attacks immune ... marrow transplant recipients. , The lateral-flow device (LFD), ... aspergillosis, a notoriously difficult to diagnose disease caused ... , Invasive aspergillosis is a leading cause ...
Breaking Medicine News(10 mins):Health News:2018 Dust Collecting Equipment Industry in China Major Enterprises Analysis Now Available at MarketReportsChina.com 2Health News:2018 Dust Collecting Equipment Industry in China Major Enterprises Analysis Now Available at MarketReportsChina.com 3Health News:Using Your Story and Not Technique to Achieve Sales Success 2Health News:Best Eye Creams for Women Over 30 Detailed in Published Guide at News Website Online 2Health News:New device detects deadly lung disease 2
(Date:7/23/2014)... CHICAGO, Ill. , July 23, 2014 ... OR IN PART, DIRECTLY OR INDIRECTLY, IN, INTO OR FROM ... OF THE RELEVANT LAWS OR REGULATIONS OF SUCH JURISDICTION. ... second-quarter 2014 financial results on Friday, July 25, 2014, before ... webcast of the earnings conference call at 8 a.m. Central ...
(Date:7/23/2014)... 2014 Research and Markets   ... Electrophysiology Ablation Catheters Market 2014-2018" report to ... Catheter ablation is a minimally ... electrical pathways from sections of the heart that ... arrhythmias). Cardiac arrhythmias can be of several types, ...
(Date:7/23/2014)... , July 23, 2014  Nonin Medical, Inc., the ... noninvasive medical monitoring, announced today that Mark VanderWerf ... been elected Chairman of the American Telemedicine Association,s (ATA) ... Directors. The ATA is the leading international ... medical technologies. The ATA and its diverse membership work ...
Breaking Medicine Technology:AbbVie to Host Second-Quarter Earnings Conference Call 2AbbVie to Host Second-Quarter Earnings Conference Call 3AbbVie to Host Second-Quarter Earnings Conference Call 4AbbVie to Host Second-Quarter Earnings Conference Call 5AbbVie to Host Second-Quarter Earnings Conference Call 6Global Electrophysiology Ablation Catheters Market 2014-2018: Key Vendors are Boston Scientific, Johnson & Johnson, Medtronic and St. Jude Medical 2Global Electrophysiology Ablation Catheters Market 2014-2018: Key Vendors are Boston Scientific, Johnson & Johnson, Medtronic and St. Jude Medical 3Nonin Medical Announces that Mark VanderWerf has been Elected Chairman of the American Telemedicine Association's Industry Council 2
Cached News: