Multiple studies have correlated elevated body-mass index (BMI) with adverse outcomes in prostate cancer. Current nomograms do not incorporate BMI as an independent predictor of disease progression following radical prostatectomy (RP). The study found that a sizable proportion of patients undergoing RP are overweight (18 percent), however, the proportion of obese patients is less than the national value (30 percent) suggesting a screening bias when selecting patients for RP. Using both pre- and post-operative risk characteristics, obese patients were at higher risk for biochemical or clinical failure (BCF) five years following RP. However, this study demonstrated that this risk was not dependent on their BMI but rather was entirely predicted by their stage, grade and PSA.

Preoperative Three-Dimensional Tumor Volume Predicts Outcome in Patients With Renal Cortical Tumors [1296]
Authors: Mitchell C Benson, M.D., Carl A. Olsson, M.D., James M. McKiernan, M.D., et al.

Traditionally, tumor diameter is considered the strongest prognostic factor when assessing patients with renal cortical tumors (RCT). However, 3-dimensional (3-D) tumor volume calculated from imaging has been demonstrated to be an independent predictor of cancer control in pharyngolaryngeal, lung and breast carcinoma. Investigators evaluated the correlation between preoperative 3-D imaging and pathologic tumor volume, and determined that preoperative 3-D imaging tumor volume correlates to pathologic 3-D volume and independently predicts disease-free survival in patients with RCTs.

Has the Predictive Significant of Positive Surgical Margins Following Prostatectomy Changes Over the Past 15 Years" [472]
Authors: Mitchell C. Benson, M.D., James M. McKiernan, M.D., Joel DeCastro, M.D., et al.

The presence of positive surgical margins (+SM) fol
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Contact: Bryan Dotson
brd9005@nyp.org
212-305-5587
New York- Presbyterian Hospital/Columbia University Medical Center
23-May-2007